Genome-wide
Detecting multiple associations in genome-wide studies
... of genome-wide studies are reviewed. Genome-wide analyses are becoming increasingly common in areas such as scans for disease-associated markers and gene expression ...of ...
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Genome-wide approaches to understanding human ageing
... nutrient-responsive kinases TOR (target of rapamycin), PKA and Sch9/Akt represent additional high-interest candidates, for which human longevity data have not been reported. More subtle effects on human ageing, which may ...
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Illuminating the genome wide activity of genome editors for safe and effective therapeutics
... the genome-wide activity of genome ...human genome is composed of repetitive ele- ments [34], and so many regions remain difficult to uniquely map and are inaccessible to modern short-read, ...
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Genome wide discovery of maternal effect variants
... a genome-wide association analysis for height, testing both the direct effect of the focal individual ’ s genotype and the indirect effect of the maternal ...
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Genome wide detection and characterization of positive selection.pdf
... The XP-EHH test detects selective sweeps in which the selected allele has risen to high frequency or fixation in one population, but remains polymorphic in the human population as a whole; for this purpose it is more ...
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Genome-Wide Structural Variation Detection by Genome Mapping on Nanochannel Arrays
... diploid genome makes it possible to identify all structural variants present with direct access to the breakpoints ...human genome sequence assembly with base-pair resolution, while feasible, is still a ...
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Genome wide gene based association study
... two-stage genome-wide association scanning procedure, consisting of a single-locus association scan for the first stage and a gene-based association scan for the second ...
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DNA methylation study of fetus genome through a genome-wide analysis
... been used to enrich and capture methylated DNA frag- ments from blood and amniotic fluid samples for use in gene-specific DNA methylation studies on a genome wide scale. According to the manufacturer’s ...
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Genome wide scan reveals association of psoriasis.pdf
... J.T.E., G.G.K., A.M.B. and G.R.A. designed and directed the study. J.D., C.H., P.E.S., D. Goldgar, B.J.F., Y.L. and G.R.A. designed and carried out the main genome scan analysis. R.P.N., K.C.D., C.H., J.D., ...
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Statistical Approaches in Genome-Wide Association Studies
... in genome-wide association studies the number of markers, p, vastly exceeds the number of observations, n, that breaks down the main assumption in classical ...
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Epigenomics: Genome-Wide Study of Methylation Phenomena
... assess genome-wide methylation status have often employed the digestion of genomic DNA with methylation-sensitive enzymes; this unfortunately limits the analysis to sites for which these specific enzymes ...
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On Considering Epistasis in genome Wide Association Studies.
... It is now possible and indeed the norm to conduct genome wide scale studies to find associations between disease phenotypes and genetic variants that may predispose to disease. The studies typically use the ...
205
Adjusted P Values for Genome-Wide Scans
... the genome-wide significance a type of profile likelihood, evincing at each analysis or adjusted P values (Westfall and Young 1993) of point the relative support for the presence of a QTL at each of the ...
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Meta analysis of genome wide association studies.pdf
... Genotyping and imputation. Subjects for the stage 1 and 2 analyses were genotyped with high-density SNP typing platforms that covered the entire human genome. In most of the studies, only unrelated samples with ...
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An Efficient Genome-Wide Multilocus Epistasis Search
... in genome-wide asso- ciation studies or genomic prediction studies can be tens of millions of markers (Georges 2014; 1000 Genomes Project Consortium ...
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Genome-wide epigenomic profiling for biomarker discovery
... current genome-wide epigenomic profiling technologies, and whether these are already or will likely become compat- ible with biomarker discovery in the near ...
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Transcriptome-Wide Association Supplements Genome-Wide Association in Zea mays.
... the genome and genetic dissection of complex trait variation remains underexplored in ...with genome-wide association studies (GWAS) and an ensemble approach that combines both GWAS and TWAS, we ...
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Genome wide transancestry meta analysis.pdf
... To assess the improvements in fine-mapping resolution by combin- ing GWAS from diverse populations, we compared the properties of the MANTRA 99% credible set on the basis of association summary statistics from the ...
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Genome-wide analysis of DNA methylation in bronchial washings
... USA). Genome-wide DNA methylation levels were measured using Infinium HumanMethylation450 BeadChip (Illumina, Inc) according to the manufacturer’ s ...
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Genome wide association studies: a primer
... Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ, Hughes TE, Groop L, Altshuler D, Almgren P, Florez JC, Meyer J, Ardlie K, Bengtsson K, Isomaa B, Lettre G, ...
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