genome-wide genetic analyses
Genome-wide genetic analyses highlight mitogen-activated protein kinase (MAPK) signaling in the pathogenesis of endometriosis
... a wide range of diseases, including cancers (Lei et ...a genetic basis and therefore likely re fl ects a causal mechanism, and furthermore, suggest that this association is limited to Stage A ...
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Genome-Wide Association Analyses in the Model Rhizobium Ensifer meliloti
... into genetic architecture and past ...tion analyses because testing for pairwise interactions typically requires large sample sizes and greatly increases the computational burden while making it more ...
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A LASSO penalized regression approach for genome wide association analyses using related individuals: application to the Genetic Analysis Workshop 19 simulated data
... To further study the TDR of the LASSO method, we reanalyzed the data using a less-strict threshold, p <1E- 04, for declaring significant SNPs with the PLINK analysis in hopes of increasing the number of actual ...
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Comparative genome analysis provides insights into the evolution and adaptation of Pseudomonas syringae pv aesculi on Aesculus hippocastanum
... phylogenetic analyses also showed that Pae belongs to a distinct clade of ...generated genome-wide Illumina sequence data from the three E-Pae strains and one strain of ...genomic analyses ...
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Sparse Simultaneous Signal Detection With Applications in Genomics
... the genetic relatedness within complex dis- ease sets through the detection and characterization of shared disease-associated SNPs among pairs of clinically-distinct disease subtypes of the ...our analyses ...
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Genome wide association analyses of North American Rheumatoid Arthritis Consortium and Framingham Heart Study data utilizing genome wide linkage results
... for Genetic Analysis Workshop 16 (GAW 16) using previously reported linkage study results for rheumatoid arthritis (RA) ...performed genome-wide linkage and association analyses of the FHS ...
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Genome-wide identification of genetic determinants for the cytotoxicity of perifosine
... The genetic determinants responsible for its cytotoxicity have not been comprehensively studied, ...a genome-wide analysis to identify genes whose expression levels or genotypic variation were ...
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Genome-wide insights into the genetic history of human populations
... Y-chromosome analyses have shown that Khoisan-speaking groups (that is, those speaking non- Bantu languages that use click consonants) from Southern Africa harbor some of the deepest rooting lineages among extant ...
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Genome-wide association meta-analyses to identify common genetic variants associated with hallux valgus in Caucasian and African Americans
... Foot disorders affect 20-60% of community-dwelling older adults[1-3] and are associated with disability[1] and falls[1, 4-6]. Hallux valgus (HV), a condition in which the great toe deviates laterally at the 1 st ...
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Genetic prediction of common complex disorders assessed by next generation sequencing and genome wide analysis
... Genome-wide association studies (GWAS) involve the analysis of a comprehensive inventory of hundreds of thousands of single- nucleotide polymorphisms (SNPs) in hundreds of thousands of cases and controls ...
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Heritability and genome wide analyses of problematic peer relationships during childhood and adolescence
... in genetic effects during childhood and adolescence is likely to be a common phenomenon in typically devel- oping ...suggesting genetic heterogeneity during development, while autistic traits are typically ...
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Genome wide QTL and eQTL analyses using Mendel
... The classical variance component model has been a powerful tool for mapping quantitative trait loci (QTLs) in pedigrees. Polygenic effects are effectively modeled by introducing an additive genetic variance ...
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Heritability and genome‐wide analyses of problematic peer relationships during childhood and adolescence
... Autism Genetic Resource Exchange (AGRE) pedigrees and the Autism Case–Control (ACC) cohort in an explora- tory search for autism ...Cleaned genome-wide data (Wang et ...
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Unraveling Fungal Radiation Resistance Regulatory Networks through the Genome Wide Transcriptome and Genetic Analyses of Cryptococcus neoformans
... through genome- wide transcriptome analysis and characterized their ...functional analyses contribute to the understanding of the unique molecular mechanism of the radiation-resistant fungus ...
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Genetic Analysis Workshop 16: Strategies for genome wide association study analyses
... influencing variation in high- and low-density lipopro- tein cholesterol (HDL, LDL), and triglycerides (TG), and 1,000 “ polygenes ” were simulated for each trait. All polygenes act independently and have additive ...
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Genome wide transancestry meta analysis.pdf
... the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of ...
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Impacts of Genome-Wide Analyses on Our Understanding of Human Herpesvirus Diversity and Evolution
... Horizontal gene transfer (HGT), or the movement of genetic material between unrelated organisms, provides another avenue for evolutionary adaptation. In the case of herpesviruses, at least 20% of the core genes ...
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Genome-Wide Expression and Location Analyses of the Candida albicans Tac1p Regulon
... Our genome-wide location experiments revealed that Tac1p binds to the promoters of a group of genes involved (or pre- dicted to be involved) in lipid ...
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Patient complexity and genotype-phenotype correlations in biliary atresia: a cross-sectional analysis
... S100A13 interacts with NDUFV3 (tagged by SNPs), a NADH dehydrogenase that belongs to the accessory sub- unit of the mitochondrial membrane respiratory chain (Fig. 1b). Other S100 members in the same CNV segment with ...
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Are genetic markers of interest for economic research?
... contain genetic information were collected by medical sci- ...linked genetic information to participants in the 1958 birth cohort ...molecular genetic variation, a number of commercial entities have ...
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