Germinal Center-B
Lethal Coinfection of Influenza Virus and Streptococcus pneumoniae Lowers Antibody Response to Influenza Virus in Lung and Reduces Numbers of Germinal Center B Cells, T Follicular Helper Cells, and Plasma Cells in Mediastinal Lymph Node
... ⫹ B cells and CD3 ⫹ CD4 ⫹ T cells. (C) Numbers in different B cell ...different B cell subpopulations. (E) Numbers of germinal center B cells, Tfh cells, and plasma cells on day ...
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Germinal Center B Cells Latently Infected with Epstein-Barr Virus Proliferate Extensively but Do Not Increase in Number
... When GC cells receive appropriate rescue signals, they up- regulate the antiapoptotic gene bcl-2 (29, 36). To test if EBV- infected GC cells undergo a similar process, we repeated the analysis described above but this ...
11
Transcription factors of the alternative NF-κB pathway are required for germinal center B-cell development
... GC B cells cultured on CD40L-expressing fibroblasts demonstrated p100 p52 processing ...LZ B cells by immunofluorescence (IF) analysis ...LZ B cells and therefore suggests that the alternative ...
24
Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity
... large B cell lymphoma [58–60], and mutations of DNA-PKcs in glioblastoma and lung cancer ...L3-type B cell acute lymphoblastic leukemia, B cell chronic lymphocytic leukemia (CLL), and, in particular, ...
14
αv Integrins regulate germinal center B cell responses through noncanonical autophagy
... Strong B cell responses are a central component of effective long-lasting immunity to ...pathogens. B cells possess the unique ability to adapt the sequence of their immune receptors during the course of ...
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Different sensitivity of germinal center B cell-like diffuse large B cell lymphoma cells towards ibrutinib treatment
... large B cell lymphoma (DLBCL), the most com- mon subtype of non-Hodgkin lymphoma (NHL) with ag- gressive property could be divided into three subgroups based on gene expression profile: germinal centre ...
9
Interleukin 10 prevents spontaneous death of germinal center B cells by induction of the bcl 2 protein
... splenic B cells, which mostly represent follicular center cells, was similarly ...Unseparated B cells as well as large splenic B cells displayed a strong expression of bcl-2 protein by ...
6
MYC chromosomal aberration in differential diagnosis between Burkitt and other aggressive lymphomas
... aggressive B-cell lymphomas, and identified a consistent gene panel characteristic of molecular ...activated B-cell-like (ABC) or germinal-center B-cell-like lymphomas (GC) ...
9
Inducible bronchus-associated lymphoid tissues (iBALT) serve as sites of B cell selection and maturation following influenza infection in mice
... GC B cells from different anatomical sites, memory and germinal center B cells were sorted from the lung, spleen, MLN and blood of mice at d35 post-infection (gating Figure S1), and ...
12
Extranodal diffuse large B-cell lymphoma with monoclonal gammopathy: an aggressive and primary refractory disease responding to an immunomodulatory agent
... rituximab, cyclophosphamide, vincristine, doxorubicin and prednisone (R-CHOP) [6]. Another clinical parame- ter reflecting the heterogeneity of this disease is the pres- ence of monoclonal gammopathy (MG) in some ...
6
Vitreoretinal lymphoma followed by systemic diffuse large B cell lymphoma
... Intraocular lymphoma is diagnosed histologically with immunohistochemistry, flow cytometry, and PCR ana- lysis [2]. Typically, intraocular lymphoma is of the non- germinal center B cell, or activated ...
5
5472.pdf
... in germinal center B cells and is essential for their formation (11, ...GC B cells, ultimately inhibiting the DNA damage response and promoting rapid proliferation within the germinal ...
146
HM71224, a selective Bruton’s tyrosine kinase inhibitor, attenuates the development of murine lupus
... (SSC). Germinal center B cells were identified as B220 + and GL7 + ...Activated B cells were identified as B220 + and CD69 + , and plasma B cells were identified as B220 + and CD138 + ...
11
A large single-institution retrospective analysis of aggressive B-cell lymphomas according to the 2016/2017 WHO classification
... aggressive B-cell ...grade B-cell lymphoma with blastoid morphology”); 2) im- munophenotype along with Ki67 proliferation index; 3) COO: germinal center B-cell phenotype (GCB) or acti- ...
7
Conserved Gammaherpesvirus Protein Kinase Selectively Promotes Irrelevant B Cell Responses
... including germinal center B ...in germinal center B cells of infected animals, despite the latent nature of viral infection in this cellular population ...malignant B ...
18
Single and Coexpression of CXCR4 and CXCR5 Identifies CD4 T Helper Cells in Distinct Lymph Node Niches during Influenza Virus Infection
... ⫹ germinal center B cells (not ...5 Germinal center T cells express ...⫺ germinal center, and CD4/CXCR4 staining on the serial section shows that germinal ...
12
journal.ppat.1002293.PDF
... and B cell-intrinsic Myd88 regulate the antibody response to a retroviral pathogen by promoting the development of germinal center B cells has potentially significant implications for ...
8
Expansion of HIV specific T follicular helper cells in chronic HIV infection
... of B cells and CD4 T cells has been shown to be fundamental for the development of high-affinity matured antibodies and for the development of long-lived memory B cells ...antigen-specific B cells ...
11
Rastelli, Julia (2007): Latent Epstein-Barr virus infection and the germinal center reaction. Dissertation, LMU München: Fakultät für Biologie
... Moreover, LMP1 signaling does not induce degradation of TRAF2 and TRAF3 as CD40, which might contribute to an enhanced signaling potency of LMP1 (Brown et al., 2001). The most striking difference between LMP1 and CD40 is ...
105
Wilms’ tumor 1-associating protein plays an aggressive role in diffuse large B-cell lymphoma and forms a complex with BCL6 via Hsp90
... In a recent paper, H Bansal et al. have proven that in vitro Hsp90 could interact with WTAP, whereas in AML cell lines the expression of WTAP could be affected by inhibitors of Hsp90 [8]. Here, we were wondering about ...
11