Germinal centers
Affinity Inequality among Serum Antibodies That Originate in Lymphoid Germinal Centers
... in germinal centers (GC), small clusters of cells in secondary lymphoid tissues including lymph nodes, spleen, and Peyer ’ s patches on intestinal mucosae ...
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Complement component 3 interactions with coxsackievirus B3 capsid proteins: innate immunity and the rapid formation of splenic antiviral germinal centers.
... The mechanisms of antigen retention for stimulation of im- mune responses in lymphoid organs have been studied exten- sively (21, 36, 37, 40, 41). Antigens interact with antibodies and activated complement component 3 ...
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Acute SIV Infection in Sooty Mangabey Monkeys Is Characterized by Rapid Virus Clearance from Lymph Nodes and Absence of Productive Infection in Germinal Centers
... Indirect immunofluorescence and confocal microscopy was used to identify and colocalize CD4 and CD3 positive cells within PCNA + germinal centers. Deparaffinized tissue sections were processed using ...
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High Frequency of Virus-Specific B Lymphocytes in Germinal Centers of Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys
... The etiology of the lymphadenopathy and follicular hyperplasia associated with human immunodeficiency virus type 1 (HIV-1) infection has remained unclear. To determine whether the B-lymphocyte expansions characteristic ...
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Detachment of Human Immunodeficiency Virus Type 1 from Germinal Centers by Blocking Complement Receptor Type 2
... After the transition from the acute to the chronic phase of human immunodeficiency virus (HIV) infection, complement mediates long-term storage of virions in germinal centers (GC) of lymphoid tissue. The ...
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How Germinal Centers Evolve Broadly Neutralizing Antibodies: the Breadth of the Follicular Helper T Cell Response
... in germinal centers occurs on the basis of antibody ...in germinal centers to explicitly define the mechanisms of selection in this complex evolutionary ...
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Lactate dehydrogenase-elevating virus replication persists in liver, spleen, lymph node, and testis tissues and results in accumulation of viral RNA in germinal centers, concomitant with polyclonal activation of B cells.
... formed germinal centers, generally at the edges of the germi- nal centers ...the germinal centers persisted at least until 90 days ...in germinal centers was removed by ...
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Case Report Langerhans cells proliferation in ectopic micronodular thymoma with lymphoid stroma: a case report
... Histoloigically, MNTs are characterized by prolif- eration of small tumor nodules focally coales- cent, separated by abundant lymphoid stromal component with germinal centers. The nodules are composed of ...
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Comparison of germinal center markers CD10, BCL6 and human germinal center-associated lymphoma (HGAL) in follicular lymphomas
... of germinal centers, ranging from few to the majority, showed partial or total substi- tution by small B-lymphoid cells with centrocyte appear- ance, immunoreactive for CD10 and BCL2 in all cases, for BCL6 ...
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Disturbances of apoptotic cell clearance in systemic lupus erythematosus
... In germinal centers, clonal selection of high-affi nity B cells results in large numbers of apoptotic cells, includ- ing autoreactive cells. Clearance of these cells is essential to maintain peripheral ...
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Pathogenesis of classical swine fever: B-lymphocyte deficiency caused by hog cholera virus.
... Already at the onset of disease, viral replication in lymphoid tissues demarcates the germinal centers, and the viral genome remains localized to that site as the disease progresses even[r] ...
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www.ijcep.com /IJCEP708008 Case Report Nodular Lymphocyte-Predominant Hodgkin Lymphoma or T-cell/Histiocyte Rich Large B-cell Lymphoma: The Problem in “Grey Zone” Lymphomas
... transformed germinal centers (PTGC), nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) and T-cell/histiocyte rich large B-cell lymphoma ...of germinal center ...
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Specificity of avian leukosis virus-induced hyperlipidemia.
... Histology summary of various leukosis viruses Histology' Subgroup A Liver Pancreas Thyroid Control MAV-1O 305 NRL NRL NRL 1+; focal 3+; interstitial infiltration; germinal centers Lympho[r] ...
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Preservation of Peripheral T Follicular Helper Cell Function in HIV Controllers
... ABSTRACT The maturation process of high-affinity antibodies is a result of intricate interactions between B cells and follicular helper T (Tfh) cells occurring in lymphoid germinal centers. HIV infection ...
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Endogenous avidin biotin activity (EABA) in thyroid pathology: immunohistochemical study
... In lymphocytic thyroiditis, intensive and widespread cyto- plasmic EABA was observed in thyrocytes with oxyphilic metaplasia that were located around lymphoid germinal centers (Figure 3)[r] ...
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Case Report Langerhans cell proliferation in micronodular thymic carcinoma with lymphoid stroma: report of a rare case
... with germinal centers of the stroma in the present case reflected the host immune response in reaction to tumor epi- thelial antigens, which is believed to be benefi- cial, leading to the improved survival ...
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PRESENCE OF PLASMA CELLS AND γ1M-GLOBULIN SYNTHESIS IN A PATIENT WITH THYMIC ALYMPHOPLASIA
... Photomicrograph of a para-aortic lymph node from Patient R.K., showing de- ficiency of small lymphocytes and absence of germinal centers (Hematoxylin and eosin. x50)[r] ...
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Possible roles of Epstein-Barr virus in Castleman disease
... into germinal center (GC-EBV) or inter-follicular (IF-EBV) localizations according to direct observation under fluo- rescent ...nal centers (GC-EBV) is defined if these signals were confined within ...
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Direct interactions of coxsackievirus B3 with immune cells in the splenic compartment of mice susceptible or resistant to myocarditis.
... splenic germinal centers of CVB3- infected A/J mice at autopsy ...a germinal center is the B cell (34, 58), which is the cell phenotype with which CVB3 associates in vivo ...
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HIV and T follicular helper cells: a dangerous relationship
... impair germinal center B cell selection and termi- nal differentiation (Figure 1, ...expanded germinal centers contain- ing increased numbers of non-antigen-spe- cific GC B cells ...of ...
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