germline stem cell
Protein synthesis and degradation are essential to regulate germline stem cell homeostasis in Drosophila testes
... in stem cells is controlled by intrinsic signals and their ...for germline stem cell (GSC) maintenance or ...spermatogonial stem cells (SSCs) in ...
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Without children is required for Stat mediated zfh1 transcription and for germline stem cell differentiation
... balancing stem cell self-renewal and ...for germline stem cell (GSC) differentiation into ...somatic cell type can then provide the germline with the support it requires ...
9
Germline Stem Cell Differentiation Entails Regional Control of Cell Fate Regulator GLD-1 in Caenorhabditis elegans
... inhibits germline stem cell fate and/or promotes meiotic entry through translational repression of mitotic genes (Biedermann et ...inhibit germline stem cell fate and/or promote ...
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Jak/Stat signalling in niche support cells regulates dpp transcription to control germline stem cell maintenance in the Drosophila ovary
... the germline is not only necessary to maintain a stable population of GSCs, but is also sufficient to specify stem cell ...required cell-autonomously in the germline (Kiger et ...female ...
8
The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking
... defective cell proliferation, apoptosis or both, we used bromodeoxyuridine (BrdU) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) labeling to examine the proliferation and apoptosis of ...
14
Notch signaling controls germline stem cell niche formation in the Drosophila ovary
... adult stem cell types are controlled by their neighboring stromal cells (Li and Xie, 2005), it remains unclear what constitutes a functional niche and how its formation is genetically ...cap cell and ...
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Cyclin E controls Drosophila female germline stem cell maintenance independently of its role in proliferation by modulating responsiveness to niche signals
... (#9661S, Cell Signaling Technology; 1:50), guinea pig anti-CycE (a gift from ...GSC-cap cell junction were similarly measured using morphometric analysis of single z-planes or maximum intensity ...of ...
11
Self maintained escort cells form a germline stem cell differentiation niche
... marks mitotic cells and their progeny (Harrison and Perrimon, 1993). This system has been used to label GSCs, FSCs, ESCs and their progeny (Margolis and Spradling, 1995; Decotto and Spradling, 2005). In the current ...
11
Drosophila small ovary gene is required for transposon silencing and heterochromatin organization, and ensures germline stem cell maintenance and differentiation
... of germline stem cells (GSCs) ensures continuous production of germ cells (Eliazer and Buszczak, ...reside stem cell niches, which are located in the germaria at the anterior tip of the ovary ...
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Adipocyte amino acid sensing controls adult germline stem cell number via the amino acid response pathway and independently of Target of Rapamycin signaling in Drosophila
... and cell types may be quite different, given the diversity of processes being ...a cell-type, context-dependent manner, and to investigate how the specificity of this pathway is achieved from budding yeast ...
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Control of germline stem cell differentiation by Polycomb and Trithorax group genes in the niche microenvironment
... crossed with UAS transgenic flies at 12 days after shifting to restrictive temperature. Spectrosomes are highlighted by α -spectrin staining (red). (A) Psc-RNAi, Su(z)2-RNAi GSC-like tumor accumulation (B) In brm-RNAi, ...
10
Maintenance of Drosophila germline stem cell sexual identity in oogenesis and tumorigenesis
... A remarkable and unexpected aspect of our analysis is that tumor formation also depends on Upd2 and Upd3 produced by somatic cells in the neighboring microenvironment. The somatic microenvironment at the tip of the ...
10
Regulation of germline stem cell proliferation downstream of nutrient sensing
... A forward genetic approach in C. elegans identified aak-2 as a downstream effector that links GSC proliferation rate with insulin-like signaling levels [28]. The screening strat- egy took advantage of the ...
9
Live imaging of the Drosophila spermatogonial stem cell niche reveals novel mechanisms regulating germline stem cell output
... differentiating germline cells to be generated at a rate that matches cyst cell ...of stem cells harboring harmful mutations within the niche, which can compete for niche occupancy (Issigonis et ...
10
The quest for male germline stem cell markers: PAX7 gets ID’d
... germ cell–deplet- ed recipient testes is usually monitored by GFP or LacZ reporter expression (7, 11, ...Sertoli cell– or Sertoli/Leydig cell–derived growth factors (7, 14, 18, ...
5
Novel Regulators in the Germline Stem Cell Niche of Drosophila Testis
... The Drosophila male germline system is an excellent model to study niche-stem cell biology. Extensive work in the field has demonstrated that signals provided by the niche play a crucial role in ...
138
Engrailed acts with Nejire to control decapentaplegic expression in the Drosophila ovarian stem cell niche
... of stem cells, which are sustained by their ...female germline stem cell (GSC) niche, Decapentaplegic (Dpp) is the primary factor that promotes GSC ...cap cell marker, binds to this ...
8
Reinterpretation of evidence advanced for neo- oogenesis in mammals, in terms of a finite oocyte reserve
... female germline stem cell (FGSC) lines from both neonatal and adult mice ovaries (the adult mice being of unspecified age), having first identified putative FGSC in the OSE of neonatal and adult mice ...
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JAK/STAT signaling in stem cells and regeneration: from Drosophila to vertebrates
... Fig. 2. JAK/STAT signaling in homeostasis and regeneration in the Drosophila testis. (A) Schematic of the adult Drosophila testis. A group of quiescent somatic cells (green) forms the niche (also referred to as the ‘ hub ...
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S6K links cell fate, cell cycle and nutrient response in C elegans germline stem/progenitor cells
... in cell number was not associated with obvious meiotic entry ...the cell cycle-promoting role of rsks-1 acts in parallel with GLP-1 and downstream of GLD-1 and ...be germline autonomous ...
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