GH secretion
Suppression of growth hormone (GH) secretion by a selective GH releasing hormone (GHRH) antagonist Direct evidence for involvement of endogenous GHRH in the generation of GH pulses
... nocturnal GH concentrations were assessed by every 10-min blood sampling until 0800 ...pulsatile GH secretion were suppressed during GHRH-Ant treatment by 40 +/- 6 (SE) % and 75 +/- 5%, ...0.02) ...
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The effect of substituted benzolactam GH secretagogue, L 692,585 on central regulation of GH secretion in swine
... Jacks T, Hickey GJ, Judith F, Taylor J, Chen H, Krupa D, Feeney W, Schoen W, Fiosher M, Ok D, Wyvratt M, Smith RG 1994 Effects of acute and repeated intravenous administration of L-692,5[r] ...
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Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man
... on GH release. Moreover, in the fed state basal GH levels are frequently undetectable, thus rendering the identification of low amplitude pulses ...of GH secretion obtained from repetitive ...
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Do IGF-I concentrations better reflect growth hormone (GH) action in children with short stature than the results of GH stimulating tests? Evidence from the simultaneous assessment of thyroid function
... that GH administra- tion to short children with decreased stimulated but normal spontaneous GH secretion is not associated with an increase of final height ...spontaneous GH secretion ...
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Simultaneous stimulation of slow wave sleep and growth hormone secretion by gamma hydroxybutyrate in normal young Men
... of GH secretion are drastically de- creased but the association between sleep onset and GH re- lease is generally maintained ...decreased GH secretion ...of GH replacement with ...
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Somatostatin receptor (SSTR) subtype selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas Novel potential therapy for functional pituitary tumors
... with GH-secreting adenomas were ...vitro GH secretion from this tumor (26%; P , ...decreased GH se- cretion by z 25% ( P , ...suppressed GH by 36– 44% ( P , ...suppressing GH ...
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Enhanced basal and disorderly growth hormone secretion distinguish acromegalic from normal pulsatile growth hormone release
... serum GH concentrations were measured at 5-min intervals for 24 h in acromegalic men and women with active (n = 19) and inactive (n = 9) disease and in normal young adults in the fed (n = 20) and fasted (n = 16) ...
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Winkelmann, Moritz (2019): Evidence for better response to somatostatin analogue treatment in acromegalic patients treated with metformin. Dissertation, LMU München: Medizinische Fakultät
... alternate GH-suppressive action of metformin has been suggested in which this compound is inhibiting GH production through suppressing STAT3 phosphorylation (An et ...induces GH hypersecretion ...
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Growth hormone response to submaximal doses of ghrelin remains unchanged during the follicular phase of the cycle
... and GH levels do not change significantly during the normal menstrual cycle ...on GH secretion is affected by ovarian ...ghrelin-induced GH secretion was ob- served with the use of ...
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Respiratory Depression in Young Prader Willi Syndrome Patients following Clonidine Provocation for Growth Hormone Secretion Testing
... 2.1. Study Design. The study was part of a randomized, longitudinal investigation that evaluated changes in energy expenditure and body composition before and following growth hormone (GH) administration in young ...
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Pulsatile growth hormone secretion in normal man during a continuous 24 hour infusion of human growth hormone releasing factor (1 40) Evidence for intermittent somatostatin secretion
... (GRF) secretion and in normal men given continuous infusions of human growth hormone releasing factor (1-40)-OH ...GRF secretion, GH secretion was pulsatile despite continuously elevated ...
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STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hypersecretion
... promote GH hypersecretion remain ...human GH-secreting adenomas compared with that in nonsecreting pituitary ...and GH expression were concordant in a somatotroph adenoma tissue ...a ...
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Effect of the Orally Active Growth Hormone Secretagogue MK 677 on Somatic Growth in Rats
... stimulate GH secretion in rats, MK-677 was administered at 2 or 4 mg/kg via the stomach ...the GH stimulatory effect was sustained after long-term use of ...
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Growth hormone deficiency and cerebral palsy
... IGF-I value can not exclude a deficient GH secretion. There is a clear reluctance in Spain, and perhaps other countries, to prescribe GH treatment for children with CP when GH deficiency has ...
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Characterisation of a functional intronic polymorphism in the human growth hormone (GHI) gene
... circulating GH and IGF-1, a reduced risk of color- ectal cancer and a predisposition to ...isolated GH deficiency, 19 while the 257G allele is associated with the complete loss of the vitamin D-induced ...
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Insulin suppresses growth hormone secretion by rat pituitary cells
... suppression of basal GH secretion was achieved by 0.7 nM insulin, and these effects were prevented by simultaneous exposure of the cells to guinea pig anti-insulin serum (1:2,000). No effects of insulin on ...
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Methscopolamine Inhibition of Sleep Related Growth Hormone Secretion: EVIDENCE FOR A CHOLINERGIC SECRETORY MECHANISM
... changed by methscopolamine. In contrast to the abolition of sleep-related GH secretion, administration of methscopolamine had only a marginal effect on the GH response to insulin hypoglycemia. None ...
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A botulinum toxin–derived targeted secretion inhibitor downregulates the GH/IGF1 axis
... High GH and IGF1 plasma levels characterizing acro- megaly induce a range of comorbidities, such as arthritis, progna- thism, glucose intolerance, and in the absence of medical control, increased mortality due to ...
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Relationship between Growth Hormone and Cytokines in Short Children Undergoing Growth Hormone Stimulation Testing
... that GH increases tumor necrosis factor (TNF)-α production in both children and ...between GH and TNF ...endogenous GH secretion and certain pro and anti-inflammatory cytokines in short ...
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Acromegaly pathogenesis and treatment
... Net GH secretion is deter- mined by integration of hypothalamic, nutri- tional, hormonal, and intrapituitary ...signals. GH synthesis and secretion are induced by hypothalamic GHRH and ...
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