Glutamate uptake
The effect of a glutamate uptake inhibitor on axon Schwann cell signalling in the squid giant nerve fibre
... The present investigation has shown that in the presence of the glutamate uptake blocker stimulation of the giant axon for periods of 5 min, but not 3 min, can activate this class of NMD[r] ...
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Borna Disease Virus Persistence Causes Inhibition of Glutamate Uptake by Feline Primary Cortical Astrocytes
... BDV has been recently implicated in “staggering disease” (SD), a neurological disorder affecting domestic cats in several parts of the world (49, 52, 59, 62). A high percentage (⬎40%) of cats with SD have been found to ...
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Effect of insulin on muscle glutamate uptake: Whole blood versus plasma glutamate analysis
... on glutamate uptake by muscle. However, whole blood glutamate analyses, performed on the same blood samples, revealed that (a) the resting muscle uptake of glutamate is smaller than ...
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Zinc Inhibits Astrocyte Glutamate Uptake by Activation of Poly(ADP-ribose) Polymerase-1
... astrocyte glutamate uptake through a mechanism involving PARP-1 activation and energy ...extracellular glutamate levels would be expected to contribute to neuronal demise, and activation of neuronal ...
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Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity
... astrocytic glutamate uptake function caused by the overproduction of cytokines such as OSM, concomitant or resulting from brain injury, might synergistically exacerbate the accumulation of extracellular ...
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Properties of glutamate uptake in glial cells
... Isolated rat cerebellar Purkinje cells were used as glutamate detectors to sense the glutamate released from Müller cells by reversed glutamate uptake (see chapter 4). 12 day old ...
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β-Catenin signaling positively regulates glutamate uptake and metabolism in astrocytes
... expression of two key proteins in the glutamate/glutamine cycle, EAAT2 and GS, are not clearly understood. Studies have identified a role of nuclear factor kappa B (NF-kB) in the regulation of astrocytic EAAT2; ...
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Stoichiometry and transport properties of the glutamate uptake carrier in salamander Muller cells
... of uptake in m ore superficial cell layers (so a higher superfused glutam ate concentration is n eed ed to satu rate to tal u p tak e) or else, m ovem ent o f uncharged glutam ate directly through the cell m em ...
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Inhibition of Astrocyte Glutamate Uptake by Reactive Oxygen Species: Role of Antioxidant Enzymes
... The free radical scavenger dimethylthiourea ef- fectively eliminated the inhibitory potential of a mixture containing hydrogen peroxide, copper sulphate, and ascorbate on the rate of glu[r] ...
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The role of glutamate transporters in glutamate homeostasis in the brain
... glial uptake being to maintain the glutamate concentration around neurones below neurotoxic ...neuronal glutamate uptake has been thought of as being in presynaptic terminals, where it would ...
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Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes
... of glutamate and GABA (2, 22, 23, 37–40), with the balance of the activity of these 2 neurotransmitters within the hypothalamus being crucial in determining metabolic output ...tamate uptake by astrocytes, ...
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Glial versus neuronal uptake of glutamate
... Biochemical studies on compartmentation in the metabolism of glutamate and the related amino acids GABA, aspartate and glutamine indicate strongly that glutamate uptake is exclusively lo[r] ...
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Computational investigation of Amyloid-β-induced location- and subunit-specific disturbances of NMDAR at hippocampal dendritic spine in Alzheimer's disease
... 21. Harris ME, Wang Y, Pedigo NW, Hensley K, Butterfield DA, Carney JM. Amyloid β Peptide (25–35) Inhibits Na+ Dependent Glutamate Uptake in Rat ‐ Hippocampal Astrocyte Cultures. Journal of neurochemistry. ...
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The chemokine, macrophage inflammatory protein-2γ, reduces the expression of glutamate transporter-1 on astrocytes and increases neuronal sensitivity to glutamate excitotoxicity
... H] glutamate uptake was determined by the method described by Lee and coworkers ...unlabeled glutamate and 0.025 μCi/ml L-[ 3 H]-glutamate (10 nM, ...UK). Uptake was terminated 10 ...
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Glutamate Transport Affects Mitochondria And Calcium Signaling In Astrocytic Processes Under Normal And Pathological Conditions
... Synaptic glutamate concentrations are kept low (approx 25 nM) via the actions of the Na + -dependent glutamate transporters in astrocytes, particularly GLT-1 and GLAST (Herman and Jahr, ...2007). ...
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Human T-Cell Lymphotropic Virus Type 1-Infected T Lymphocytes Impair Catabolism and Uptake of Glutamate by Astrocytes via Tax-1 and Tumor Necrosis Factor Alpha
... astrocytes. Uptake of extracellular glutamate by astrocytes was significantly decreased after transient contact with infected T cells, while the expression of the glial trans- porters GLAST and GLT-1 was ...
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Factors shaping excitatory synaptic currents in cerebellar Purkinje cells
... f glutamate-gated ion ...the glutamate analogue PDC (300p.M), which is known to block glutamate uptake (Bridges et a l, 1994), reversibly reduced the current when applied on top o f the ...
249
PubMedCentral-PMC5220558.pdf
... of glutamate that cannot be buffered or cleared effectively, resulting in damaging levels of glutamate in the extracellular ...of glutamate homeostasis may initiate additional changes in ...
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Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage
... decreased glutamate uptake, (b) reverse transport, and (c) hete- ...net glutamate uptake within 2 to 3 minutes (33), and at later stages, ischemia promotes reverse glutamate transport ...
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The Relationship between Glutamate and Multiple Sclerosis
... extracellular glutamate, and is considered as one of the major processes of nerve cells death, and also plays a major role in various diseases such as neurodegenerative disorders, ischemia, trauma and multiple ...
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