Glycoprotein Ib
Structural basis of von Willebrand factor binding to platelet glycoprotein Ib and collagen Effects of disulfide reduction and limited proteolysis of polymeric von Willebrand factor
... requirements for vWF binding with platelet glycoprotein Ib (GpIb), heparin, and collagen and have shown that fragments derived from large vWF multimers retain biologic activity. We have shown that a ...
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Point mutation in a leucine rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard Soulier syndrome
... GP Ib alpha fragments to demonstrate that the observed mutation is the cause of defective von Willebrand factor ...the glycoprotein Ib-IX-V receptor complex and, possibly, for normal platelet ...
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Alternative expression of platelet glycoprotein Ib(beta) mRNA from an adjacent 5' gene with an imperfect polyadenylation signal sequence
... platelet glycoprotein Ib b transcription initiation site can support reporter gene expression in human erythroleukemia (HEL) cells suggesting it may represent a megakaryocytic promoter ...
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Platelet storage results in a redistribution of glycoprotein Ib molecules Evidence for a large intraplatelet pool of glycoprotein Ib
... Platelet membrane glycoprotein (GP) Ib contains receptor for von Willebrand factor and thrombin. Its proteolytic fragment, glycocalicin, circulates in normal plasma. In this study, storage of platelet ...
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Interaction of asialo von Willebrand factor with glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and mediates platelet aggregation
... aggregation in the absence of any other stimulus. Asialo vWF, unlike the native molecule, does not require ristocetin to interact with platelets. Agglutination induced by ristocetin is largely independent of active ...
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Complementary DNA cloning of the alternatively expressed endothelial cell glycoprotein Ib beta (GPIb beta) and localization of the GPIb beta gene to chromosome 22
... In this paper we show that the GPIb, mRNA and protein species are larger in endothelial cells ECs than in platelets and HEL cells, report the cDNA sequence of endothelial GPIbfl, and eva[r] ...
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Variant Bernard Soulier syndrome type bolzano A congenital bleeding disorder due to a structural and functional abnormality of the platelet glycoprotein Ib IX complex
... of glycoprotein (GP) Ib were used to estimate the number of GP Ib molecules on the platelet ...GP Ib alpha, as well as GP IX, in patient ...GP Ib alpha from surface-labeled ...GP ...
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Platelet Glycoprotein Ib: A Zinc-Dependent Binding Protein for the Heavy Chain of High-Molecular-Weight Kininogen
... (1996) Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and Factor. XII: Identity with the receptor that binds to the[r] ...
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Linkage of a membrane skeleton to integral membrane glycoproteins in human platelets Identification of one of the glycoproteins as glycoprotein Ib
... GP Ib, GP Ia, a minor membrane glycoprotein of 250,000 Mr, and actin-binding protein resulted from their association with actin filaments as they were rendered Triton X-100-soluble when actin filaments ...
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Expression of the phenotypic abnormality of platelet type von Willebrand disease in a recombinant glycoprotein Ib alpha fragment
... Willebrand disease, thus establishing the molecular basis of the bleeding disorder within this family. Moreover, it becomes apparent that structural elements responsible for the regulation of hemostasis through ...
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NH2 terminal globular domain of human platelet glycoprotein Ib alpha has a methionine 145/threonine145 amino acid polymorphism, which is associated with the HPA 2 (Ko) alloantigens
... The glycoprotein (GP) Ib/IX complex, a prominent platelet GP complex, is the primary receptor for vWF. Previously, we have established that an antigenic polymorphism of platelets, the HPA-2 or Ko ...
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Quality control of riboflavin-treated platelet concentrates using Mirasol® PRT system: Polish experience
... GMP-140 glycoprotein, CD62P antigen) as a re- sult of intensive alpha granule ...for glycoprotein Ib (antigen CD42b) is reduced, and the expression of the active form of fibrinogen receptor GP ...
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Von Willebrand's disease with spontaneous platelet aggregation induced by an abnormal plasma von Willebrand factor
... antibody directed against glycoprotein Ib (GPIb) and/or a monoclonal antibody against the glycoprotein IIb/IIIa (GPIIb/IIIa) complex totally inhibits the SPA. The vWf was isolated from the plasma of ...
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Combination of acquired von Willebrand syndrome (AVWS) and Glanzmann thrombasthenia in monoclonal gammopathy of uncertain significance (MGUS), a case report
... light-transmission-aggregometry (LTA) with a normal response to ristocetin. Platelet functional analyser stud- ies show prolonged closure values to Collagen/ADP and Collagen/Epinephrine. Ristocetin mediates vWF binding ...
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Push me pull you: comparative advertising in the OTC analgesics industry
... Market Shares and Advertising Levels of OTC Analgesics Brands Brand Tylenol Advil Aleve Excedrin Bayer Motrin Generic Generic Generic Generic.. ACT IB NS ACT ASP IB ACT IB ASP NS.[r] ...
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Single Molecule Studies of Myosin-Ib
... We consider three possible reasons for the rapid reversals in force seen in figures 2.8 and 3.25. (1.) An unfolding event, or loss of calmodulin causes a rapid relaxation along the lever arm of myo1b during an event. ...
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Push Me Pull You: Comparative Advertising in the OTC Analgesics Industry
... Market Shares and Advertising Levels of OTC Analgesics Brands Brand Tylenol Advil Aleve Excedrin Bayer Motrin Generic Generic Generic Generic.. ACT IB NS ACT ASP IB ACT IB ASP NS.[r] ...
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Cell Structure and Function - IB mod.pdf
... cell, involved in organelle movement throughout cell, chromosome movement during cell division and large cell movements (cell motility and. cytokinesis)[r] ...
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Stats IB 2013.doc
... Problem 2: The following table shows data collected by a candy company on the number of candies in a box of caramel chews. The company inspected 100 boxes. Determine the mean, median,[r] ...
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Institutional influences on SME exporters under divergent transition paths: Comparative insights from Tajikistan and Kyrgyzstan
... Over the last two decades, research in international business (IB) has extended its empirical and conceptual reach beyond its traditional ‘core Triad’ roots, yet certain parts of the world are still largely ‘off ...
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