GM-CSF
GM CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice
... between GM-CSF and Th2 cy- tokines detected in OVA-exposed ...of GM-CSF and IL-4 is re- quired for optimal expansion of dendritic cells ...of GM-CSF expression, OVA initiates a ...
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PCR-mediated Expression of the Human GM-CSF Gene in Escherichia coli
... weight marker of 14 kDa was identified. As is seen in Figure 3A. Also in western blot analysis (Lane 2 in Fig. 3B) the corresponding band could be detected. The supernatant of induced cell extract was assayed by ELISA ...
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A randomized study comparing chemotherapy followed by G-CSF alone or in combination with GM-CSF for mobilization of peripheral blood stem cells in patients with non-Hodgkin’s lymphomas
... Objective: Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) are the two most commonly used cytokines for mobilization of stem cells in ...
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STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE
... of GM-CSF ex- pression by effector CD4 T cells revealed that the major- ity of the IFNγ+IL-17A+ double-producing cells in WT mice during EAE concurrently express GM-CSF, and this may explain ...
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Aging diminishes the resistance of AO rats to EAE: putative role of enhanced generation of GM-CSF Expressing CD4+ T cells in aged rats
... of GM-CSF [8, 9]. Al- though Th1 cells are also shown to produce GM-CSF, they most likely do not represent an important source of GM-CSF in EAE ...of GM-CSF in T ...
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15 kDa Granulysin versus GM CSF for monocytes differentiation: analogies and differences at the transcriptome level
... of GM-CSF alone are able to differentiate into iDCs, although these iDCs show a reduced ability to induce an effective activation of lym- phocytes after maturation ...that GM-CSF leads to a ...
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GM CSF contributes to aortic aneurysms resulting from SMAD3 deficiency
... investigated GM-CSF levels as a potential media- tor of the cooperation between the adaptive and innate immune ...lacking GM-CSF failed to initiate neuroinflammation despite their IL-17A or ...
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Clinical uses of GM-CSF, a critical appraisal and update
... introduced GM-CSF as an important adjuvant in cancer vaccine trials, based on his observations that irradiated tumor cells expressing murine GM-CSF could stimulate potent, long-lasting, and ...
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Research Upregulation of CD23 (FcεRII) Expression in Human Airway Smooth Muscle Cells (huASMC) in Response to IL-4, GM-CSF, and IL-4/GM-CSF
... and GM-CSF on the expression of CD23, and the doses chosen were IL-4 ...and GM-CSF ...except GM-CSF which was obtained from ...
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Blockade of collagen induced arthritis post onset by antibody to granulocyte macrophage colony stimulating factor (GM CSF): requirement for GM CSF in the effector phase of disease
... to GM-CSF or isotype control mAb. Anti-GM-CSF mAb treatment prior to the onset of arthritis, at the time of antigen challenge, was effective at ameliorating the ensuing ...of ...
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Original Article YKL-40 siRNA downregulates the expression of eotaxin, IL-5, GM-CSF in an epithelial cell model of asthma
... eotaxin, GM-CSF, and IL-5, which are potent chemotactic factors for the recruitment of eosinophils through the CCR3 receptor, contrib- uting to airway ...
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GM-CSF as a therapeutic target in autoimmune diseases
... cells, GM-CSF-producing CD4 T cells, and neutrophils with fibrosis in the lungs ...of GM-CSF was reported to induce severe neutrophil, eosinophil, and macrophage infiltration with fibrosis in ...
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GM CSF action in the CNS decreases food intake and body weight
... GM-CSF receptor in situ hybridization. Antisense probe for GMRα mRNA was hybridized to mouse brain sections. Signal was observed in the region of the PVN in sections. Signal from hybridization with control ...
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Pulmonary epithelial cell expression of GM CSF corrects the alveolar proteinosis in GM CSF deficient mice
... from GM-CSF-null mutant mice (GM 2 / 2 ), described pre- viously ...of GM-CSF cDNA from ...SP-C-GM- CSF-transgenic (0.5 kb) alleles. SP-C-GM-CSF transgenic ...
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Recombinant human granulocyte macrophage colony stimulating factor (GM CSF) shortens the period of neutropenia after autologous bone marrow transplantation in a primate model
... human GM- CSF for several days both before and after transplantation or only after the transplant ...of GM-CSF, neutrophil counts fell to values comparable to those observed in untreated ...
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Evaluation of pre-treatment serum levels of IL-7 and GM-CSF in colorectal cancer patients
... of GM-CSF in CRC and the mechanisms behind its dual (or multiple) role against tumor cells is not ...serum GM-CSF levels may reflect a protective response in cancer patients, while higher ...
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Neutrophil GM-CSF receptor dynamics in acute lung injury.
... TABLE 1 Bactericidal effect of increasing exposure times and acid concentrations Solution characteristicsa Acid and/or conditions BSA and RBC concn %c pH Log10 reduction of viable bacter[r] ...
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Comparative Measurement of Cell-Mediated Immune Responses of Swine to the M and N Proteins of Porcine Reproductive and Respiratory Syndrome Virus
... the GM-CSF-PRRSV-M and GM-CSF-PRRSV-N genes with primer set GM-CSF FP and PRRSV-M RP1 and primer set GM-CSF FP and PRRSV-N RP1 (Table 1), ...the ...
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Granulocyte macrophage colony stimulating factor induces CCL17 production via IRF4 to mediate inflammation
... the GM-CSF–driven pathway(s) in monocytes/macrophages, leading to expression of other key proin- flammatory cytokines, such as IL-1β and ...the GM-CSF–treated monocyte/mac- rophage populations ...
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Dynamic DNA methylation change in the CpG island region of p15 during human myeloid development
... of GM-CSF alone, as shown in Figures 2c and ...with GM-CSF + SCF, methylation of the p15 CpG island was maintained for up to 14 days at a modestly high level relative to the values obtained ...
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