GSH depletion
The Pro-Oxidant Activity of Pheomelanin Is Significantly Enhanced by UVA Irradiation: Benzothiazole Moieties Are More Reactive than Benzothiazine Moieties
... of GSH levels in pheomelanic birds, suggesting that PM might be toxic when combined with nuclear radiation ...depletes GSH stores, which could make melanocytes more susceptible to oxidative damage and ...
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Novel metabolic biomarkers related to sulfur-dependent detoxification pathways in autistic patients of Saudi Arabia
... [40,41]. Oxidative stress caused by GSH depletion may also play a role in the increased male to female ratio observed in autism. Because of lower levels of reduced glutathione, mitochondria from males, when ...
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Oxidative Stress-Inducing Carbonyl Compounds From Common Foods: Novel Mediators of Cellular Dysfunction
... dependent depletion of GSH was ob- served, using standard glycated proteins; maximal GSH depletion was induced by MG-derivatives ( 75% below baseline), followed by AGE-LDL and Ox-LDL, while ...
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Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes
... Mitochondrial GSH depletion by ethanol feeding preceded the onset of functional changes in mitochondria, suggesting that mitochondrial GSH is critical in maintaining a functionally competent ...
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ANTIOXIDATIVE EFFECT OF EPIGALLOCATECHIN GALLATE AGAINST D-GALACTOSAMINE-INDUCED INJURY IN PRIMARY CULTURE OF RAT HEPATOCYTES
... Summary: Literature data support that green tea and its major component epigallocatechin gallate (EGCG) have pow- erful antioxidant effects. Contrary, hepatotoxicity can be induced by high-dose EGCG. The timing of ...
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Emmler, Judith (2004): In-vitro-Toxizität von Inhaltsstoffen aus dentalen Restaurationsmaterialien. Dissertation, LMU München: Tierärztliche Fakultät
... signifikante Depletion des intrazellulären Redox- Schutzmoleküls Glutathion ...zellinternen GSH-Vorräte nach Exposition mit subtoxischen Komonomer-Konzentrationen wieder voll regeneriert, während bei der ...
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Hepatoprotective Effect of Ginseng, Green Tea, Cinnamon Their Combination against Acetamiprid - induced Oxidative Stress in Rats
... GSH depletion leads to increased lipid Peroxidation and necrosis of hepatocytes. Also, the activity of glutathione-s-transferase (GST) which is a multifunctional enzyme and plays a key role in cellular ...
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Astrocytes Prevent Ethanol Induced Apoptosis of Nrf2 Depleted Neurons by Maintaining GSH Homeostasis
... in GSH antioxidant ...to depletion of intracellular GSH ...of GSH and caspase mediated cell death of cortical neurons that are compromised in Nrf2 machinery (Narasimhan et ...mainly GSH ...
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Alterations in Energy/Redox Metabolism Induced by Mitochondrial and Environmental Toxins: A Specific Role for Glucose-6-Phosphate-Dehydrogenase and the Pentose Phosphate Pathway in Paraquat Toxicity
... total GSH/GSSG (reduced [GSH] or oxidized [GSSG]) (Supporting Information Figure ...total GSH/GSSG content (Supporting Information Figure 1E and F and Figure ...(including GSH) forming ...
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Loupatatzis, Barbara (2007): Die CRH-Rezeptor-vermittelte Wirkung von CRH auf das GSH-GSSG-Redoxsystem von Endothelzellen. Dissertation, LMU München: Medizinische Fakultät
... des GSH durch ...der GSH-Biosynthese ...der GSH-Biosynthese erfolgt oder zusätzlich eine GSH- Depletion induziert ...intrazellulären GSH-Konzentration sein, wäre eine Erhohlung ...
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Comparison of toxic responses to acetaminophen challenge in ICR mice originating from different sources
... following GSH depletion [20], we examined the level of GSH and lipid peroxidation in the liver as well as the parameters of hepatotoxicity including the activ- ity of alanine aminotransferase (ALT) ...
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Modification of intracellular glutathione status does not change the cardiac trapping of 64Cu(ATSM)
... Neither GSH depletion nor augmen- tation affected developed pressure or lactate release during perfusion with normoxic or hypoxic ...Neither GSH augmentation nor GSH depletion had any ...
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Stress hormones promote growth of B16 F10 melanoma metastases: an interleukin 6 and glutathione dependent mechanism
... 5). GSH (one of the key endogenous ef- fectors involved in regulating activation of cell death path- ways [56]), if maintained at high levels, was capable of preventing the corticosterone-induced apoptosis (Table ...
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Oxido reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1
... wall ROS generation was confined largely to the medium. Network analysis directed us towards the orphan proto- oncogene RTK ROS1 as a potential mediator. We vali- dated the importance of this mechanism in humans by ...
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Hepatoprotective activity of Sonchus asper against carbon tetrachloride induced injuries in male rats: a randomized controlled trial
... DNA damage in the form of DNA adducts, genetic muta- tion, strand breakage, and chromosomal alterations [10]. Some recent investigations revealed that free radicals increased the number of argyrophilic nucleolar ...
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Comparison of Alcohol Free GSH Production by Ultrasonic and Homogenizing Method
... of GSH can also be used as the production method of GSH if the amount of the GSH is not the major ...of GSH production which can reduce the operational cost and shorten the production ...that ...
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Characterization of Peripheral Neuropathy in Rat Model of Type 2 Diabetes
... Figure 4: Levels of SOD, GSH, and MNCV in type 2 diabetic animals. Glibenclamide treatment normalized GSH levels. B) A significant reduction in GSH was observed in paclitaxel (p<0.001[r] ...
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Biliary excretion of glutathione and glutathione disulfide in the rat Regulation and response to oxidative stress
... of GSH was modulated by the administration of diethyl maleate or acetaminophen, the biliary concentration of GSH was consistently lower than, but directly proportional to, ...
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On the Depletion Layer
... the depletion layer gives smaller values for the thickness of the depletion layer and the capacity of the equivalent condenser than that obtained for the model that assumes volume charge distribution in the ...
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“HERBAL TREATMENT OF PARKINSONISM: A REVIEW ARTICLE” by Borra Kartika*, Palayyan Muralidharan, Habibur Rahman, India.
... Myung Sook Oh et al provided the scientific basis to support the traditional use of the Uncaria rhynchophylla in Parkinson’s disease. Uncaria rhynchophylla possess the neuroprotective activity against 6-OHDA toxicity in ...
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