GTPase activity
Guanylate-Binding Protein 1, an Interferon-Induced GTPase, Exerts an Antiviral Activity against Classical Swine Fever Virus Depending on Its GTPase Activity
... proliferative activity to restrict the cell-to-cell spread of progeny virus (14, ...the activity of NF-B and further contributes to the produc- tion of antiviral and proinflammatory cytokines ...the ...
15
Cytosolic chaperonin CCT possesses GTPase activity
... the GTPase activity of CCT may con- tribute to directly regulate the tubulin folding in ...the GTPase activity of the CCT may play an im- portant role in the function of CCT in living ...
8
<p>Indole-core-based novel antibacterial agent targeting FtsZ</p>
... Results: The screening study from a small library consisting of benzimidazole and indole derivatives discovered a compound (CZ74) with an indole-core structure. The compound exhibited strong cell division inhibitory ...
14
LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same
... kinase activity, in particular Rab proteins, and advances in understanding the activation of LRRK2 kinase activity via dimerisation and association with membranes, especially via interaction with ...LRRK2 ...
22
Inositol 1,4,5 triphosphate induced granule secretion in platelets Evidence that the activation of phospholipase C mediated by platelet thromboxane receptors involves a guanine nucleotide binding protein dependent mechanism distinct from that of thrombin
... Specifically, it has been shown that thrombin stimulates GTPase activity in platelets e.g., 25, that the addition of GTP or nonhydrolyzable GTP analogues to permeabilized platelets cause[r] ...
8
An Arabidopsis reticulon and the atlastin homologue RHD3 like2 act together in shaping the tubular endoplasmic reticulum
... The effect of RL2 and RTNLB13 on ER morphology is independent of GTPase activity and requires a functional reticulon Tobacco leaves were infiltrated with agrobacteria containing the indi[r] ...
21
Thromboxane insensitive dog platelets have impaired activation of phospholipase C due to receptor linked G protein dysfunction
... impaired. GTPase activity stimulated by U46619, but not by thrombin, was markedly reduced in TXA2- ...U46619-induced GTPase activity in TXA2-, TXA2+, and human ...
12
Investigating the antiviral activity of the interferon inducible GTPase MxA against influenza viruses
... antiviral activity was attributed to the loss of GTPase activity as a result of the mutation, which was also suggested to be the reason for the punctate aggregation, as MxA is thought to require ...
317
GTPase-Activating Proteins for Cdc42
... tional proteins with GAP activity for Cdc42 or that the inher- ent GTPase activity of Cdc42 is sufficient for viability (27, 67). The localization of actin, chitin, and septin rings was exam- ined in ...
12
System Wide Characterization of MoArf GTPase Family Proteins and Adaptor Protein MoGga1 Involved in the Development and Pathogenicity of Magnaporthe oryzae
... The Arf proteins activate vesicle transport by recruiting coat protein complex COPI, COPII, and most clathrin coat proteins (22). Due to the clathrin coats not directly binding to lipids, adaptors are needed for ...
20
Biological insights from a simulation model of the critical FtsZ accumulation required for prokaryotic cell division
... An additional role of the Z-ring that is not included in the model is the recruitment of peptidoglycan remodeling enzymes on the outside of the inner cell membrane. 47 As the Z-ring contracts, the peptidoglycan ...
30
Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins.
... The GTPase activity of huMxA has been measured while it was still bound to polyclonal antibodies on protein A-Sepharose beads, and it represents an intrinsic activity of huMxA protein fo[r] ...
5
A Monomeric GTPase-Negative MxA Mutant with Antiviral Activity
... antiviral activity or whether MxA monomers are also antivirally ...and GTPase activity, mutations in LZ1 should abolish backfolding and oligomerization and presumably reduce the enzymatic ac- tivity ...
5
The G proteins of the G alpha i and G alpha q family couple the bradykinin receptor to the release of endothelium derived relaxing factor
... membranes from pertussis toxin-treated cells. The combination of P4 and EC antisera produced a loss of HABS (41%) and GTPase activity (40%) comparable to the effects of pertussis toxin. These findings ...
6
Functional Comparison of Mx1 from Two Different Mouse Species Reveals the Involvement of Loop L4 in the Antiviral Activity against Influenza A Viruses
... antiviral activity as a result of decreased GTPase activity (40, ...antiviral activity through an altered dimerization at the G ...stimulated GTPase activity, this should have ...
12
srGAP1 mediates the migration inhibition effect of Slit2-Robo1 in colorectal cancer
... Cdc42 activity through srGAP1 Cdc42, a key member of Rho GTPases, could prompt cell migration by regulating actin ...the GTPase activity of Cdc42 in LoVo cells transfected with Slit2, RoboN, ...
10
The Rab GTPase family
... endosomal GTPase Rab5a has several different effectors, and this is probably true for other Rabs as well ...Rab GTPase may be capable of regulating several molecular events at a restricted membrane ...
7
Morphogenetic Circuitry Regulating Growth and Development in the Dimorphic Pathogen Penicillium marneffei
... Many genes that are required for P. marneffei growth, morpho- genesis, and development have been identified and characterized. Their molecular and cellular roles have been uncovered, as have their interrelationships. A ...
7
Pathogenic Escherichia coli Hijacks GTPase Activated p21 Activated Kinase for Actin Pedestal Formation
... a role for EspG in pedestal formation may also be the reason that Rho GTPases have not been shown to be required; as the function of the Rho GTPase is to allow EspG to bind and recruit PAK, only under conditions ...
13
Haas, Alexander (2008): Regulation of endocytosis and secretion by Rab GTPase activating proteins. Dissertation, LMU München: Fakultät für Biologie
... Why is such a “regulator GAP” like TBC1D20 needed? One possibility is, that the regulation of the initiation vesicle transport is coupled to recognition of properly folded cargo as a proofreading mechanism before the ...
168