Guanylate cyclase
Increased guanylate cyclase activity is associated with an increase in cyclic guanosine 3',5' monophosphate in left ventricular hypertrophy
... myocardial guanylate cyclase ...late cyclase via intracoronary injection of the nitric oxide donor 3-morpholino-sydnonimine (SIN-1), which increased cyclic GMP to a greater extent in the left ...
9
Polymerase chain reaction localization of constitutive nitric oxide synthase and soluble guanylate cyclase messenger RNAs in microdissected rat nephron segments
... Soluble guanylate cyclase mRNA is expressed largely in glomerulus, proximal convoluted tubule, proximal straight tubule, and cortical collecting duct, and in small amounts in medullary thick ascending limb, ...
8
Atrial natriuretic factor significantly contributes to the mineralocorticoid escape phenomenon Evidence for a guanylate cyclase mediated pathway
... the guanylate cyclase-coupled natriuretic peptide receptors impairs the ability of the kidney to escape the Na+ retaining effect of excess mineralocorticoid in a dose-dependent ...
10
Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen
... Guanylate cyclase 2C (encoded by Gucy2c , hereafter termed GC-C) is a transmembrane receptor present in the intestine which, in concert with its ligands guanylin (GN, encoded by Guca2a ,) [5] and ...
13
Mutations in the GUCA1A gene involved in hereditary cone dystrophies impair calcium mediated regulation of guanylate cyclase
... So far, only seven putative pathogenic mutations in the GUCA1A gene have been reported in patients with adCD, adCRD or adMD: p.Pro50Leu, p.Tyr99Cys, p.Asn104Lys, p.Thr114Ile, p.Ile143delinsAsnThr, p.Leu151Phe, and ...
15
Soluble guanylate cyclase stimulation: an emerging option in pulmonary hypertension therapy
... E ndothelial cell-derived nitric oxide (NO) acts on vascular smooth muscle cells in healthy subjects to induce vasodilation by increasing production of the secondary messen- ger cyclic guanosine monophosphate (cGMP) via ...
7
Nitric oxide decreases stability of mRNAs encoding soluble guanylate cyclase subunits in rat pulmonary artery smooth muscle cells
... Nitric oxide stimulates soluble guanylate cyclase (sGC) to convert GTP to the intracellular second messenger cGMP. In rat pulmonary artery smooth muscle cells, sGC is an obli- gate heterodimer composed of a ...
8
Original Article Guanylate cyclase-C signaling pathway regulates intestinal inflammatory injury and epithelial barrier function in Caco-2 cells
... Background: Guanylate cyclase-C (GC-C) signaling pathway via guanylin (Gn) and uroguanylin (Ugn) activa- tion regulates intestinal fluid and electrolyte ...
11
Original Article Effects of methylene blue on the nitric oxide-soluble guanylate cyclase-cyclic guanylyl monophosphate pathway and cytokine levels in rats with sepsis
... Abstract: Background: Methylene blue (MB) inhibits the production of nitric oxide (NO) and cyclic guanylyl mono- phosphate (cGMP) and thus reverses septic hypotension, but the specific effects of MB on the NO-soluble ...
9
Axonal wiring of guanylate cyclase D expressing olfactory neurons is dependent on neuropilin 2 and semaphorin 3F
... may also have mechanosensory abilities (Grosmaitre et al., 2007). Second, the Grueneberg ganglion, located at the tip of the nose (Grueneberg, 1973), is now regarded as an olfactory subsystem (Fuss et al., 2005; Koos and ...
10
Tissue Guanosine 3′,5′ Cyclic Monophosphate Levels and Soluble Guanylate Cyclase Activity: A POSITIVE CORRELATION DURING UNILATERAL CRYPTORCHIDISM IN THE RAT TESTIS
... of guanylate cyclase and tissue guanosine-3¢,5¢-cyclic monophosphate (cGMP) levels was investigated in rat testes after surgically induced unilateral ...homogenate guanylate cyclase activity ...
10
Riociguat: a soluble guanylate cyclase stimulator for the treatment of pulmonary hypertension
... (NO)–soluble guanylate cyclase (sGC)–cyclic guanosine 3′,5′-monophosphate (cGMP) pathway has been shown to play an important role in cardiovascular physiology, especially in vasodilation and pulmonary ...
13
Genetic modifiers of hypertension in soluble guanylate cyclase α1–deficient mice
... soluble guanylate cyclase (sGCa 1 ), are prone to hypertension in some, but not all, mouse strains, suggesting that additional genetic factors contribute to the onset of ...
11
Role of adenylate cyclase, guanylate cyclase enzyme and phosphodiesterase isozyme modulation in animal models of epilepsy.
... hormones, such as natriuretic factors, activate receptors that are associated with membrane bound guanylate cyclase (GC). Receptor activation of GC leads to the conversion of GTP to cGMP. Nitric oxide (NO) ...
33
Guanylate cyclase 2C agonism corrects CFTR mutants
... Cystic fibrosis (CF) is a genetic disorder in which epithelium-generated fluid flow from the lung, intestine, and pancreas is impaired due to mutations disrupting CF transmembrane conductance regulator (CFTR) channel ...
14
Activation of Guanylate Cyclase-C With Heat-Stable Enterotoxin Fails to Potentiate Celecoxib-Induced Reduction in Colorectal Cancer Cell Growth in Vitro
... This study evaluated the use of heat-stable enterotoxin ST, a guanylate cyclase receptor type C GC-C agonist, in combination with celecoxib, a cyclooxygenase-2 COX-2 inhibitor, for the p[r] ...
73
Lack of Guanylate Cyclase C results in increased mortality in mice following liver injury
... The family of particulate guanylate cyclases (GC) is known to play substantial roles in the function of a number of different organs. These membrane receptors include the natriuretic peptide receptors GC-A and GC- ...
9
The Carbon monoxide releasing molecule ALF-186 mediates anti-inflammatory and neuroprotective effects via the soluble guanylate cyclase ß1 in rats’ retinal ganglion cells after ischemia and reperfusion injury
... AMC: Activated microglia; CO: Carbon monoxide; CORM: Carbon monoxide releasing molecule; CREB: cAMP responsive element binding protein; DMSO: Dimethylsulfoxid; FG: Fluorogold; GCL: Gangl[r] ...
14
Role of adenylate cyclase, guanylate cyclase enzyme and phosphodiesterase isozyme modulation in animal models of epilepsy.
... Phosphodiesterase enzymes regulate the degradation of cyclic AMP a product of the adenylate cyclase activation and could contribute to the pathophysiology of the seizure mechanisms (Conti, 1999). Seizures, ...
205
Atrial natriuretic peptide receptor subtype determination and biological actions of atrial natriuetic peptided in bovine cardiac muscle and hypertensive rat liver
... and guanylate cyclase analysis w ith BNP is required to support this ...that guanylate cyclase activity was stimulated up to 2-fold by ...stimulate guanylate cyclase activity up ...
196