H1 receptor
Cetirizine a histamine H1 receptor antagonist improves viral myocarditis
... In recent years, mast cells have been implicated in the pathogenesis of cardiovascular and atherosclerotic disor- ders. In particular, we have observed that mast cells cause apoptosis of cardiac myocytes and ...
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Effects of chlorpheniramine (histamine H1 receptor antagonist) on food and water intake in broiler chickens in hunger and satiety
... Bnvshy H1 receptor, which Caused by histamine is involved, these results with results of Rossi et al (Rossi et ...the H1-receptor antagonist resulted in a significant reduction in water ...
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Simultaneous Determination of Amlodipine with H1 Receptor Antagonists by Reversed Phase High Performance Liquid Chromatography and Application to Interaction Studies
... ABSTRACT A rapid, fast and precise method has been developed and validated for the simultaneous determination of amlodipine with H1-receptor antagonists cetirizine, fexofenadine, and buc[r] ...
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Molecular determinants of ligand binding at the human histamine H1 receptor: Site directed mutagenesis results analyzed with ligand docking and molecular dynamics studies at H1 homology and crystal structure models
... NH moiety formed a hydrogen bond to the carbonyl oxygen of N5.46 (2.8 Å), as for the homology model. The orientation of the Y3.33 side chain in the 3RZE structure was close to the histamine imidazole moiety and the pros ...
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Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation
... Interestingly, the functional consequences of histamine in microglial phagocytosis remain unexplored. Microglia phagocytose foreign pathogens, stressed/apoptotic cells, and also supernumerary synapses in postnatal ...
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THE EFFECT OF HISTAMINE H1 RECEPTOR ANTAGONISTS ON THE MORPHINE INDUCED ANTINOCICEPTION IN THE ACUTE TRIGEMINAL MODEL OF NOCICEPTION IN RATS
... central Gi-protein by peripheral administration of diphenhydramine, pyrilamine, and promethazine suggested as one of the mechanisms that contribute in the analgesic activity of these first-generation antihistamines in ...
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SPECTROFLUORIMETRIC DETERMINATION OF SOME H1 RECEPTOR ANTAGONIST DRUGS IN PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL FLUIDS
... These value lie within the working concentration range of the proposed spectrofluorimetric method, thus it could be successfully applied to the determination of the studied drugs in spik[r] ...
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Role of H1 receptors and P selectin in histamine induced leukocyte rolling and adhesion in postcapillary venules
... via H1 receptor activation, (b) histamine-induced recruitment of rolling leukocytes is mediated in part by P-selectin expressed on the endothelial cell surface, and (c) the histamine-induced vascular ...
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Antihistamines and allergies – an update
... of H1-receptor antagonists is very similar, their pharmacological properties differ and literature suggests that second generation H1 antihistamines are the preferred treatment ...
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Combination of H1 and H2 Receptor Antagonists in Treatment of Asthmatic Patients
... life. H1 receptor blockers are not known to be effective in the treatment of Asthma ...of H1 and H2 receptor antagonists are thought to be effective in the treatment of chronic resistant ...
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Antihistamines and allergies
... Pruritus is troublesome in patients suffering from atopic dermatitis or eczema. Histamine is however only one of the mediators to cause pruritus and the older generation antihistamines are indicated at bedtime due to ...
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Early Alterations of the Receptor-Binding Properties of H1, H2, and H3 Avian Influenza Virus Hemagglutinins after Their Introduction into Mammals
... virus-like receptor- binding ...the receptor-binding site, 226Q3L, whereas Albany/57 contains two substitutions, 226Q3L and ...in receptor-binding activity, with their affinity for 6⬘SLN-PAA ...
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Soluble RAGE and atherosclerosis in youth with type 1 diabetes: a 5-year follow-up study
... Methods: Participants in the prospective atherosclerosis and childhood diabetes study were examined at baseline (aged 8–18) and at follow‑up after 5 years. Both sRAGE and esRAGE were measured by immunoassay in 299 ...
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Histamine receptor H1 is required for TCR mediated p38 MAPK activation and optimal IFN γ production in mice
... Histamine receptor H 1 (H 1 R) is a susceptibility gene in both experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune orchitis (EAO), 2 classical T cell– mediated models of organ-specific ...
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A Multiband Multiple-input Multiple-output Antenna System for Long Term Evolution and Wireless Local Area Networks Handsets
... Effect of the length (H1) of S-Shaped strip on the reflection coefficient of the proposed MIMO antenna, where H1= 4mm is an optimized value.. As H1 (hence the lengt[r] ...
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<p>Effects of loratadine, a histamine H<sub>1</sub> receptor antagonist, on the skeletal system of young male rats</p>
... chlorpheniramine, favorably affected the skeletal system of old mice. 30 Promethazine and meclozine counteracted the development of estrogen de fi ciency-induced bone changes in rats and mice, respectively; 29,31 however, ...
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The H1 histamine receptor regulates allergic lung responses
... Histamine, signaling via the type 1 receptor (H1R), has been shown to suppress Th2 cytokine production by in vitro cultured T cells. We examined the role of H1R in allergic inflammation in vivo using a murine ...
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Development of a Pan-H1 Influenza Vaccine
... strains H1/California/ 07/2009 (CA09) and H1/New Caledonia/20/1999 (NC99) were selected by the WHO and remained unchanged in the vaccine composition for extended periods, 2010 to 2017 and 2000 to 2007, ...
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Transformation of narrowband wavetrains of surface gravity waves passing over a bottom step
... The transformation coefficients depend on the water depths ratio only; their graphics are depicted in Fig. 1 in the semi-logarithmic scale. As it might be expected, when the depths h 1 and h 2 are equal, then there is no ...
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HIV-1 Tat Protein Induces PD-L1 (B7-H1) Expression on Dendritic Cells through Tumor Necrosis Factor Alpha- and Toll-Like Receptor 4-Mediated Mechanisms
... Toll-like receptor 4 (TLR4), (v) was absent in TLR4- knockoout (KO) mice but could be restored following incubation with Tat-conditioned medium from wild-type DCs, (vi) im- paired the capacity of MoDCs to ...
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