Heat Shock Factor
Azadiradione ameliorates polyglutamine expansion disease in Drosophila by potentiating DNA binding activity of heat shock factor 1
... cellular heat shock response (HSR) and compromised protein quality control pathways are common hallmarks of various NDs ...cells heat shock factor 1 (HSF1), the central regulator of ...
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The L-Type Cyclin CYL-1 and the Heat-Shock-Factor HSF-1 Are Required for Heat-Shock-Induced Protein Expression in Caenorhabditis elegans
... affected heat-shock-induced GOA-1 ...expression. Heat-shock-induced expression of ...under heat-shock ...under heat-shock control, suggesting a role in general ...
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Tissue specific expression of zebrafish (Danio rerio) heat shock factor 1 mRNAs in response to heat stress
... upon heat shock at 37 °C ...h heat shock at 35 °C and more pronouncedly at 37 °C, with a corresponding reduction in the amount of the constitutive HSC70 ...to heat stress (Dyer et ...
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Requirement for endogenous heat shock factor 1 in inducible nitric oxide synthase induction in murine microglia
... )-nuclear factor- κ B (NF- κ B) cascade, whereas interferon- γ (IFN- γ ) acts through Janus kinase (JAK)-signal transducer and activator of transcription 1 (STAT1) ...signals. Heat shock ...
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Heat Shock Factor 1 Predicts Poor Prognosis of Gastric Cancer
... Fig. 4. Overexpression of HSF1 promotes proliferation, migration, and invasion of gastric cancer cells. Overexpression of HSF1 in AGS and MKN28 cells was achieved by transfection with an empty vector (pcDNA_EV) or HSF1 ...
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Identification of heat shock factor binding protein in Plasmodium falciparum
... regulating heat shock response: (i) heat shock factors (HSF), which are transcription factors regulating heat shock protein (hsp) genes; (ii) heat shock elements ...
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Heat shock factor 1, an inhibitor of non-homologous end joining repair
... The heat shock factor (HSF)1 activation is critical for maintaining homeostasis of the proteomes of cells and is mediated in large part by increased expression of classical heat shock ...
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Heat shock factor 2 is activated during mouse heart development
... fashion. Heat shock factor, HSF, was first identified as a heat-inducible transcription factor that upon activation interacts with the heat shock element, HSE, within the ...
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Bortezomib-induced heat shock response protects multiple myeloma cells and is activated by heat shock factor 1 serine 326 phosphorylation
... cytoprotective heat shock response (HSR), including upregulation of heat shock proteins ...regulator, Heat Shock Factor 1 ...
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Genetic Analysis of Tissue Aging in Caenorhabditis elegans: A Role for Heat-Shock Factor and Bacterial Proliferation
... elegans heat-shock factor (HSF), a transcription factor that regulates the response to heat and oxidative ...that heat-shock proteins, many of which act as chaperones, may ...
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MicroRNA-644a promotes apoptosis of hepatocellular carcinoma cells by downregulating the expression of heat shock factor 1
... Heat shock factor 1 (HSF1) is a protective factor that is induced during various stress conditions including extrinsic environmental stress or intrinsic age-related deterioration ...
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Nitric oxide induces heat shock protein 70 expression in vascular smooth muscle cells via activation of heat shock factor 1
... expected, heat shock induced HSF1 translocation in SMCs ...and heat stress resulted in an increased HSF1 in nuclei and a shift to higher molecular weight species ...
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Increased expression of heat shock factor 1 (HSF1) is associated with poor survival in gastric cancer patients
... Our previous studies confirmed that HSP70/HSP90-or- ganizing protein (HOP) could act as an oncogene by regulating malignant progression of gastric cancer, and high HOP expression predicted worse long-term out- come in GC ...
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Thermal acclimation changes DNA binding activity of heat shock factor 1 (HSF1) in the goby Gillichthys mirabilis: implications for plasticity in the heat shock response in natural populations
... Furthermore, in the time 0, 13°C- and 21°C-acclimated groups, a decrease in HSF1 activation was observed at the highest heat shock temperature. Although HSF1 activation in the 28°C-acclimated group ...
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Akt Phosphorylation of Drosophila Heat-Shock Factor: A Signature for Stress Resistance
... exhibiting heat-stress induced ub gene ...to heat stress accounted for the majority of proteins that were ubiquitylated during ...principal heat shock pathway components, hsp70, is rapidly ...
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Robust Transcriptional Response to Heat Shock Impacting Diverse Cellular Processes despite Lack of Heat Shock Factor in Microsporidia
... Fungal species display great variance in their tolerance to increased temperatures, but the majority prefer 12 to 30°C, while only a select few species are able to tolerate temperatures higher than 35°C (1). The ...
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Neurospora crassa heat shock factor 1 Is an Essential Gene; a Second Heat Shock Factor-Like Gene, hsf2, Is Required for Asexual Spore Formation
... In contrast, no Neurospora HSFs have yet been isolated, although HSPs are expressed in this organism during heat shock and cell differentiation (14, 19) suggesting that, as seen for other organisms, the ...
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Heat shock protein 70 down-regulates the production of toll-like receptor-induced pro-inflammatory cytokines by a heat shock factor-1/constitutive heat shock element-binding factor-dependent mechanism
... Designs, and formerly Stressgen Biotechnologies Cor- poration). We tested conventional, non-LPS-free Hsp70 (NSP-555), which we will refer to as “HE/Hsp70”; and LPS-free Hsp70 (ESP-555), which we will refer to as “Hsp70”. ...
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Heat shock factor 1 protein in heat shock factor 1 gene transfected human epidermoid A431 cells requires phosphorylation before inducing heat shock protein 70 production
... It has been reported that overexpression of HSF1 in mu- rine fibroblast cells does not change HSP-70 gene expression, despite the fact that it rendered the cells more resistant to the cytotoxic effects of heat ...
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Heat shock protein and heat shock factor 1 expression and localization in vaccinia virus infected human monocyte derived macrophages
... a heat shock in human blood adherent monocytes was also found [32], therefore the heat shock response seems to be similar in this aspect to the vaccinia virus ...the heat shock ...
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