heat shock factor 1
Tissue specific expression of zebrafish (Danio rerio) heat shock factor 1 mRNAs in response to heat stress
... of heat shock proteins (HSPs) is regulated at both transcriptional and post-transcriptional ...the heat shock transcription factor (HSF), which is present as an inactive form in ...
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Requirement for endogenous heat shock factor 1 in inducible nitric oxide synthase induction in murine microglia
... Heat shock factor 1 (HSF1) is a major transcriptional factor in the cell with numerous pathophysiological ...binds heat shock element (HSE) in the pro- moter of ...
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MicroRNA-644a promotes apoptosis of hepatocellular carcinoma cells by downregulating the expression of heat shock factor 1
... In this study, we investigated the role of microRNA-644a (miR-644a) in the growth and survival of hepatocellular carcinoma (HCC) cells. MiR-644a levels were lower in HCC tissues than in adjacent peri-cancerous tissues ( ...
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Heat Shock Factor 1 Predicts Poor Prognosis of Gastric Cancer
... Fig. 4. Overexpression of HSF1 promotes proliferation, migration, and invasion of gastric cancer cells. Overexpression of HSF1 in AGS and MKN28 cells was achieved by transfection with an empty vector (pcDNA_EV) or HSF1 ...
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Bortezomib-induced heat shock response protects multiple myeloma cells and is activated by heat shock factor 1 serine 326 phosphorylation
... cytoprotective heat shock response (HSR), including upregulation of heat shock proteins ...regulator, Heat Shock Factor 1 ...
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Heat shock protein 70 down-regulates the production of toll-like receptor-induced pro-inflammatory cytokines by a heat shock factor-1/constitutive heat shock element-binding factor-dependent mechanism
... infection, heat shock or cellular ...of Heat shock protein 70 (Hsp70) confer cytoprotection [1] by inhibiting components of inflammatory signaling pathways, such as the NF-κB ...
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Heat shock factor 1, an inhibitor of non-homologous end joining repair
... A novel role for HSF1 as an inhibitor of non-homologous end joining (NHEJ) repair activity was identified. HSF1 interacted directly with both of the N-terminal sequences of the Ku70 and Ku86 proteins, which inhibited the ...
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Heat shock protein and heat shock factor 1 expression and localization in vaccinia virus infected human monocyte derived macrophages
... a heat shock in human blood adherent monocytes was also found [32], therefore the heat shock response seems to be similar in this aspect to the vaccinia virus ...the heat shock ...
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Neurospora crassa heat shock factor 1 Is an Essential Gene; a Second Heat Shock Factor-Like Gene, hsf2, Is Required for Asexual Spore Formation
... Deleting hsf2 had a dramatic effect on asexual development; aerial hyphae developed but no conidial chains formed. The following six mutants blocked at different stages of conidial development have been placed in a ...
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Thermal acclimation changes DNA binding activity of heat shock factor 1 (HSF1) in the goby Gillichthys mirabilis: implications for plasticity in the heat shock response in natural populations
... e.g. heat shock and oxidative stress (Gosslau et ...of heat shock proteins (Hsps) – a powerful tool for mediating the negative effects of thermal stress (Lindquist, 1986; Parsell and ...
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Increased expression of heat shock factor 1 (HSF1) is associated with poor survival in gastric cancer patients
... Our previous studies confirmed that HSP70/HSP90-or- ganizing protein (HOP) could act as an oncogene by regulating malignant progression of gastric cancer, and high HOP expression predicted worse long-term out- come in GC ...
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Heat shock factor 1 protein in heat shock factor 1 gene transfected human epidermoid A431 cells requires phosphorylation before inducing heat shock protein 70 production
... HSF1–heat shock element complex was significantly increased in both the nucleus and cytosol in HSF1 gene–transfected cells, in- dicating increased synthesis of ...with 1 m M PMA (a protein kinase C ...
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Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs
... (StressGen) for 1 h at room temperature. Isotype-matched mono- clonal antibodies (Dako, Glostrup, Denmark) served as controls. Af- ter rinsing, endogenous peroxidase was blocked with 0.3% hydrogen peroxide in ...
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Nitric oxide induces heat shock protein 70 expression in vascular smooth muscle cells via activation of heat shock factor 1
... to heat shock or stress remains to be ...regulating heat shock response in which the hsps them- selves negatively regulate heat shock gene expression via an autoregulatory loop ...
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Prognostic role of HSF1 overexpression in solid tumors: a pooled analysis of 3,159 patients
... PubMed, Embase, and Web of Science was performed by two investigators independently (updated on June 15, 2017) by retrieving articles published in English only and using the following search terms: (“heat ...
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The L-Type Cyclin CYL-1 and the Heat-Shock-Factor HSF-1 Are Required for Heat-Shock-Induced Protein Expression in Caenorhabditis elegans
... affected heat-shock-induced GOA-1 expression. The cyl-1 mutants are essentially wild type in appearance, while hsf-1 and sup-45 mutants have egg-laying ...expression. ...
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Heat shock factor 2 is activated during mouse heart development
... and heat-shocked (42 ° C, 1 h) rat pheochromocytoma (PC12) cells were prepared by homogenization in two volumes of high salt buffer containing 20 mM Hepes, pH ...for 1 h at RT, followed by incubation ...
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Proteomic analysis of human periodontal ligament cells under hypoxia
... inducible factor-1; hPDLCs: Human periodontal ligament cells; HSP: Heat shock protein; HSPA8: Heat shock 70 kDa protein 8; HSPB1: HSP beta 1; IHC: Immunohistochemistry ...
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miR 18, a member of Oncomir 1, targets heat shock transcription factor 2 in spermatogenesis
... There is a wealth of evidence for the role of the miR-17~92 cluster in cancer. By contrast, very little is known about the physiological functions of the cluster and especially of the functions of its individual members. ...
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Bioinformatic analysis of RpoH sigma factors from the anoxygenic phototrophic Rhodobacter species
... sigma factor ( σ factor). The type of sigma factor binding to the core RNA polymerase and then to a promoter vary according the type of the genes and several environmental ...sigma factor ...
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