Hedgehog signaling pathway
A Genetic Screen in Drosophila for Identifying Novel Components of the Hedgehog Signaling Pathway
... The Hedgehog signaling pathway plays an essential role in the pattern formation and development of metazoan ...of Hedgehog signaling has also been associated with the formation of ...
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The Hedgehog Signaling Pathway in the Ischemic Heart, Brain, and Skeletal Muscle
... Hh pathway may help revascularization and repair of ischemic ...Hh pathway in the pathophysiology of the EPC compartment has been recently further strengthened by the demonstration that Gli1 and Ptch ...
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Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened
... companies mainly focused on targeting SMO. Several SMO inhibitors are currently being tested in clinical trials for the treatment of multiple types of cancer. The most extensively studied SMO inhibitor is cyclopamine ...
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Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy
... of Hedgehog (Hh) signaling pathway. The Hh signaling pathway contains three Hh homologs: Sonic Hh, indian Hh, and Desert ...Hh pathway is, generally, inhibited at “Off” ...
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Gene Expression Profiling of the Hedgehog Signaling Pathway in Human Meningiomas
... Hh pathway genes and 5 of 9 Hh-inducible genes, re- lated to cell proliferation/invasion, dif- fered significantly as regards total or each grade of meningiomas and normal tissue (Table 2), although the changes ...
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Understanding the role of the Sonic Hedgehog signaling pathway in cerebellar development and medulloblastoma genesis
... We generated a mouse allograft tumor line by orthotopically transplanting tumor cells from the genetically engineered mouse model (GEMM) of medulloblastoma - Ptch1 conditional knock out model (Ptch1 flox/flox ; ...
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Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma
... Hh, Hedgehog; HPI, Hedgehog pathway inhibitor; KCASH, KCTD (Potassium Channel Tetramerization Domain) containing cullin3 adaptor suppressor of hedgehog; MEK, mitogen-activated protein kinase ...
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Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine
... Shh signaling could preserve cardiac function and improve cardiac recovery in the context of myocardial ...Shh signaling in AMI and myocardial ischemia-reperfusion–induced injury models are summarized in ...
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Targeting glioma stem cells via the Hedgehog signaling pathway
... sonic Hedgehog (Shh), Indian Hedgehog (Ihh) and desert ...Hh signaling are patched (Ptch) and smoothened ...Hh signaling, enters the nucleus, leading to nuclear translocation and activation of ...
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Roles of the Hedgehog Signaling Pathway in Skin Development, Homeostasis and Cancer
... Keywords: Hedgehog signaling; skin; epidermis; hair follicle; development; homeostasis; basal cell.. 20.[r] ...
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Gastric cancer and Hedgehog signaling pathway: emerging new paradigms
... Drosophila, hedgehog signaling has been linked to foregut development, The mammalian genome expresses three Hedgehog paralogues, sonic hedgehog (Shh), Indian Hedgehog, and desert ...
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Role of canonical Hedgehog signaling pathway in liver
... Hh signaling pathway activation, such as, pitchfork (Pifo), the G protein-coupled receptor associated sorting protein 2 (Gprasp2) and Growth Arrest Specific 8 (Gas8) are essential components of an Hh ...
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The zebrafish mutants dre, uki, and lep encode negative regulators of the hedgehog signaling pathway.
... the Hedgehog (Hh) signaling ...Hh signaling pathway in these ...Hh signaling pathway. The effects of increased Hh signaling resulting from the genetic alterations in the ...
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The Design, Synthesis, and Biological Evaluation of Steroid-Derived Inhibitors of the Sonic Hedgehog Signaling Pathway
... With the assistance of John Tellis, the graduate student that designed the seminal photoredox cross-coupling work, and Simon Berritt, the Director of the Merck High-Throughput Experimentation Laboratory at Penn, a small ...
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Therapeutic potential of hedgehog signaling pathway agonist
... intercellular signaling molecule first observed in fruit flies of the genus ...developmental pathway involved in organogenesis, stem cell maintenance, and tissue repair/regeneration ...[1]. Hedgehog ...
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High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma
... Sonic Hedgehog (SHH) signaling pathway contributing to carcinogenesis of some organs has been reported in the ...SHH pathway contributes to the recurrence of breast ...Sonic Hedgehog ...
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Drugging Hedgehog: signaling the pathway to translation
... the Hedgehog signaling pathway ...this pathway, stimulated by the discovery of the vertebrate homologues of the hedgehog (hh) gene that had originally been studied in ...Hh ...
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Original Article Gene expression profiling and identification of key genes involved in neonatal hypoxic-ischemic brain injury
... insult. Pathway clustering analysis was performed and a functionally grouped pathway network of DEGs was con- ...constructed. Hedgehog signaling pathway was identified and ...
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Original Article Pathway analysis of esophageal squamous cell carcinoma using iTRAQ-based quantitative proteomic approach
... signal pathway could be divided into five types including Notch signaling pathway, Wnt signaling pathway, NF- kappa B signaling path- way, Hedgehog signaling ...
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... of Hedgehog pathway in the absence of the ...autocrine/juxtacrine Hedgehog signaling. The Hedgehog ligand is secreted by the tumor cell and taken up into the same tumor cell (autocrine ...
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