Hedgehog signalling
Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling
... Sonic hedgehog signalling is essential for the embryonic development of many tissues including the central nervous system, where it controls the pattern of cellular ...Shh signalling-regulated ...
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Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin 1β
... induced hedgehog signalling, the basal levels of hedge- hog signalling was not measured in these ...of hedgehog signal- ling via Ihh-induced upregulation of Gli1 and Ptch1 ...the ...
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Two populations of endochondral osteoblasts with differential sensitivity to Hedgehog signalling
... murine Hedgehog signalling pathway mutants are embryonic lethal, we chose to undertake studies in the zebrafish, which have a number of advantages that make them ideal for studies of this ...the ...
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Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates
... (Hh) signalling plays a crucial role in animal development, controlling cell type specification, proliferation and survival in a variety of contexts through a pathway that has been highly conserved during ...
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Antagonistic cross regulation between Wnt and Hedgehog signalling pathways controls post embryonic retinal proliferation
... on Hedgehog signalling activity by examining the effects of a 24-hour BIO ...Wnt signalling in the CMZ (Denayer et ...the Hedgehog transcriptional targets Ptc1 and Gli1 was virtually ...
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Restriction of sonic hedgehog signalling during early tooth development
... Shh signalling in mandibular explants from ...Shh signalling during early odontogenesis, it is clearly important to restrict the sites of activity along the developing oral axis specifically to the sites of ...
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The Interplay between Hedgehog Signalling and BMP Signalling in Regulating B cell Development
... of signalling cross-talk (Bitgood and McMahon, 1995; Guo and ...Hh signalling pathway have been detected within both the Thymic (Outram et al 2000, Sacedon et ...that Hedgehog proteins influence ...
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Hedgehog Signalling in the Embryonic Mouse Thymus
... Hedgehog signalling to DN thymocytes negatively regulates pre-TCR-induced differentiation to DP cell in both mouse and human ...Hh signalling negatively regulates DN to DP differentiation in foetal ...
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Genetic analysis of hedgehog signalling and the regulation of patched gene expression in vertebrate embryos
... An alternative, more complex scenario would be that the igu mutants are hypomorphic alleles of a positive regulator of the Hh pathway. In this event, the ectopic expression of p tcl could ensue as a consequence of the ...
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Sonic hedgehog signalling from foregut endoderm patterns the avian nasal capsule
... sonic hedgehog (Shh) is expressed in the most anterior part of the endoderm, endoderm zone I (EZ-I), of the early chick embryo (Brito et ...Shh signalling (Jeong et al., 2004). The importance of Shh ...
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Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon
... Hh signalling and subsequently acquire prethalamic or thalamic fate but cells that require longer range Hh signalling are not able to respond appropriately in smu mutants, suggesting an inductive relay ...
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The miR 30 microRNA family targets smoothened to regulate hedgehog signalling in zebrafish early muscle development
... expression (Fig. 2F) suggesting upregulation of the pathway. As a positive control for Hh pathway activation dnPKA mRNA (dominant negative Protein Kinase A) was injected into zebrafish embryos (Fig. 2C,G,K). Protein ...
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A shared role for sonic hedgehog signalling in patterning chondrichthyan gill arch appendages and tetrapod limbs
... Fig. 4. A dual role for Shh signalling in gill arch anteroposterior patterning and proliferative expansion. (A) Successively earlier treatment with cyclopamine results in a progressively greater reduction in ...
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Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus
... Although cilia in mice lacking Evc look normal on stan- dard microscopy [7] the possibility remained that the Hh signalling defect could be secondary to a structural abnormality of cilia. We therefore examined ...
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Repression of Hedgehog signalling is required for the acquisition of dorsolateral cell fates in the zebrafish otic vesicle
... Hh signalling is overactivated by shh or dnPKA overexpression in the zebrafish embryo, anterior otic structures are absent and posterior regions are duplicated (Hammond et ...
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Hedgehog signalling
... involvement of the PC in Hh signalling across vertebrates (Huang and Schier, 2009; Yin et al., 2009). The central role of the PC in transduction of the Hh signal is reflected in the dynamic localisation of the ...
6
Hedgehog signalling is required for cloacal development in the zebrafish embryo
... The Smo antagonist, cyclopamine, was used to elucidate the temporal requirements for Hh signalling. Despite ihha being expressed from mid-somitogenesis and shha from 24 hpf, in the posterior gut region, ...
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Sonic hedgehog signalling as a potential endobronchial biomarker in COPD
... Shh signalling, was also found on non-differentiated and differentiated cells from isolated AEC and ...crine signalling in the ...HH signalling, which is particularly interesting, as genetic al- ...
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The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy
... Hh signalling present in breast cancer, espe- cially since the therapeutic target may be SMO expressed by the normal stromal cells rather than the neoplastic cells ...Hh signalling [57], although such cases ...
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Hepatic autophagy is differentially regulated in periportal and pericentral zones - a general mechanism relevant for other tissues?
... Implications of the hypothesis: Zonation of the regulation of autophagy may allow adapting the extent of the proteolytic breakdown of proteins and organelles to different physiological needs in different zones of liver ...
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