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Hematopoietic Stem Cells

Hematopoietic Stem Cells

Hematopoietic Stem Cells

... Hematopoietic Stem Cells Michael E. Trigg, MD ABSTRACT. The hematopoietic system of the young child acquires, through time, the ability to cope with exposure to a number of environmental ...

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Hematopoietic stem cells in Drosophila

Hematopoietic stem cells in Drosophila

... vertebrate hematopoietic stem cell ...fide hematopoietic stem cells (HSCs) in the lymph glands of embryos and young larvae, which give rise to a hematopoietic ...precursor ...

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Hematopoietic stem cells and retroviral infection

Hematopoietic stem cells and retroviral infection

... infect hematopoietic stem and progenitor cells, resulting in the deregulation of normal hematopoiesis and the development of ...tic stem cell traits, and the cancer stem cell ...in ...

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Hematopoietic stem cells and the genetics of aging

Hematopoietic stem cells and the genetics of aging

... Introduction Hematopoietic stem cells (HSCs) sustain lifelong production of mature blood ...suggesting stem cell exhaustion 1-10 ...transplanted stem cells showed impaired ...

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Embryonic stem cell-derived hematopoietic stem cells

Embryonic stem cell-derived hematopoietic stem cells

... embryonic stem cells (ESCs), achieving stable long-term blood engraftment of ESC-derived hematopoietic stem cells in irradiated mice has proven ...the hematopoietic lineage. ...

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2. BONE MARROW (HEMATOPOIETIC) STEM CELLS

2. BONE MARROW (HEMATOPOIETIC) STEM CELLS

... purified hematopoietic stem cells as grafts is ...tumor cells in the case of autologous grafts, therefore not inducing GVHD, or presumably GVL, 139–141 in allo- geneic ...donor cells ...

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Ex vivo Expansion of Hematopoietic Stem Cells

Ex vivo Expansion of Hematopoietic Stem Cells

... with hematopoietic stem cell transplantation (HSCT) ...of hematopoietic stem cells (HSC) such as umbilical cord blood (CB) have been ...a stem cell source has increased ...

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Allantois and placenta as developmental sources of hematopoietic stem cells

Allantois and placenta as developmental sources of hematopoietic stem cells

... definitive hematopoietic stem cells during development, the mouse placenta has been found to generate large numbers of these cells and to remain functional in this respect for a longer period ...

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BRPF1 is essential for development of fetal hematopoietic stem cells

BRPF1 is essential for development of fetal hematopoietic stem cells

... Hematopoietic stem cells (HSCs) serve as a life-long reservoir for all blood cell types and are clinically useful for a variety of HSC transplantation-based ...and hematopoietic progenitors, ...

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The analysis, roles and regulation of quiescence in hematopoietic stem cells

The analysis, roles and regulation of quiescence in hematopoietic stem cells

... adult stem cells that are capable of efficient self-renewal and differentiation; some of these have been shown to exist in a dormant, or quiescent, cell cycle ...of hematopoietic stem ...

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Optimation of Hematopoietic Stem Cells Culture Medium: A Review

Optimation of Hematopoietic Stem Cells Culture Medium: A Review

... Hematopoietic stem cells (HSCs) usage has numerous potential benefits for basic and clinical research. Growing interest in this field is caused by possible HSCs application to cure various ...

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Therapy Development by Genome Editing of Hematopoietic Stem Cells

Therapy Development by Genome Editing of Hematopoietic Stem Cells

... of hematopoietic stem cells (HSCs) for the manipulation and repopulation of the blood and immune systems has placed them at the forefront of cell and gene therapy develop- ...

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Deciphering ARAP3 Functions in Hematopoiesis and Hematopoietic Stem Cells

Deciphering ARAP3 Functions in Hematopoiesis and Hematopoietic Stem Cells

... and hematopoietic stem cells ...in hematopoietic cells and in several cell types within the HSC ...in hematopoietic cells using Vav-Cre does not alter the ability of ...

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Expansion of hematopoietic stem cells for transplantation: current perspectives

Expansion of hematopoietic stem cells for transplantation: current perspectives

... UCB stem cells, intraosseous infusion of UCB cells, activating homing receptors (such as CXCR4), and use of double cord blood units ...of hematopoietic stem cells have been met ...

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Characterizing A Signaling Network That Maintains Hematopoietic Stem Cells

Characterizing A Signaling Network That Maintains Hematopoietic Stem Cells

... Klein Hematopoietic stem cells (HSCs) are able to self-renew and to differentiate into all blood ...receive hematopoietic cytokines, but they then lose the ability to ...

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Aging of hematopoietic stem cells: DNA damage and mutations?

Aging of hematopoietic stem cells: DNA damage and mutations?

... the hematopoietic system and the stem cell niche contributes to aging-associated phenotypes of hematopoietic stem cells (HSCs), including leukemia and aging-associated im- mune ...young ...

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Increased mir33 Expression in Expanded Hematopoietic Stem Cells Cultured on Adipose Stem Cells Feeder layer

Increased mir33 Expression in Expanded Hematopoietic Stem Cells Cultured on Adipose Stem Cells Feeder layer

... of hematopoietic stem cells for regenerative medicine have been largely unsuccessful due to the inability to create sufficient stem cell numbers and also to excessive differentiation of them ...

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Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells

Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells

... Nucleostemin is a nucleolar protein known to play a variety of roles in cell-cycle progression, apoptosis inhibition, and DNA damage protection in embryonic stem cells and tissue stem cells. ...

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Wild-type Kras expands and exhausts hematopoietic stem cells

Wild-type Kras expands and exhausts hematopoietic stem cells

... in hematopoietic stem cells (HSCs) induces a rapidly fatal myeloproliferative neoplasm in mice, suggesting that Kras signaling plays a dominant role in normal ...

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A new chapter: hematopoietic stem cells are direct players in immunity

A new chapter: hematopoietic stem cells are direct players in immunity

... Hematopoietic stem cells (HSCs) are responsible for the daily production of all blood and immune cells in the body and have been widely used in transplantation to treat patients with leukemia, ...

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