Hematopoietic stem cells/progenitors
Cellular and molecular architecture of hematopoietic stem cells and progenitors in genetic models of bone marrow failure
... myeloid progenitors in patients with FA/SDS suggests that these cells feature higher survival or growth properties and possibly harbor some of the initial transformational events that lead to ...GMP-like ...
18
Strategies for enrichment and selection of stem cell-derived tissue precursors
... manipulate stem cells, proteins expressed on the cell surface were used to identify distinct populations of stem cells and their ...pluripotent stem cells can be identifi ed by ...
14
TNF inhibits production of stromal cell derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood
... of hematopoietic stem cells and progenitors – mediates TNF- induced OCP mobilization, we first verified that OCPs express functional CXCR4 and migrate toward a SDF-1 gradient in a combined ...
10
Protein arginine methyltransferase 1 is required for maintenance of normal adult hematopoiesis
... megakaryocyte progenitors (MkPs) compared with similarly treated littermate control ...short-term hematopoietic stem cells (ST-HSCs) and granulocyte-macrophage progenitors (GMPs) ...
11
Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells
... erythroid/myeloid progenitors (EMPs) and hematopoietic stem cells (HSCs) from hemogenic endothelium during ...liver cells, demonstrating that the requirement for Runx1 changes over ...
12
The journey of developing hematopoietic stem cells
... progenitor cells, consistent with its important role in producing differentiated blood ...of hematopoietic differentiation ...lymphoid progenitors accumulate with developmental ...liver ...
12
The ratio of ADSCs to HSC-progenitors in adipose tissue derived SVF may provide the key to predict the outcome of stem-cell therapy
... studies, hematopoietic pro- genitor cells and pericytes, were shown to possess char- acteristics similar to ADSCs, and therefore could grow in adherent culture and displayed mesenchymal multi- potency [25, ...
20
Enrichment of therapeutic hematopoietic stem cell populations from embryonic stem cells
... The hematopoietic lineage arises out of the mesoderm layer through a common progenitor cell for endothelial and hematopoietic lineages, termed the hemangioblast ...mesoderm cells in the posterior ...
127
Neonatal expression of RNA binding protein IGF2BP3 regulates the human fetal adult megakaryocyte transition
... fetal progenitors do not execute the adult morphogenesis program of enlargement, polyploidization, and proplatelet ...blood stem cell transplantation and may underlie inefficient platelet production by ...
14
MSX2 suppression through inhibition of TGFβ signaling enhances hematopoietic differentiation of human embryonic stem cells
... hESC hematopoietic differentiation goes through three main stages, including mesoderm induction, the emer- gence of hemogenic endothelium progenitors (HEPs), and generation of hematopoietic ...
12
Stem cell biology is population biology: differentiation of hematopoietic multipotent progenitors to common lymphoid and myeloid progenitors
... in stem cell biology ...of stem cell systems is determined by the availability of molecular resources, feedbacks from differ- entiated cells, the effects of the epigenetic environment and the size of ...
14
Nuclear fission safety programme 1992-94: Radiation protection research action, Final report, Volume 2. EUR 16769
... To determine whether the effects produced in the most primitive lympho-hematopoietic selfrenewing stem cells were consistent with data obtained in the clonogenic progenitors, bone marrow[r] ...
1224
Vol 70, No 3 (2018)
... enhances stem cell proliferation to the detriment of their differentiation potential ...their stem cell ...human hematopoietic progenitors and stem cells respond to hypoxia have ...
9
Understanding Megakaryopoiesis And Thrombopoiesis Using Human Stem Cells Models
... term-hematopoietic stem cell (LT- HSC) and the short term-hematopoietic stem cell (ST-HSC) in the bone marrow are at the top of the hematopoietic hierarchy and give rise to all the ...
123
Nuclear factor of activated T-cells, NFATC1, governs FLT3ITD-driven hematopoietic stem cell transformation and a poor prognosis in AML
... the stem cell leukemia (Scl ) enhancer (SCL- Cre-ER T ) and transgenic Flt3 ITD mice [19], thus targeting NFATC1 expression to Flt3 ITD -positive hematopoietic stem ...
12
A SY Stematic approach towards understanding stem cell biology
... In her keynote lecture, Janet Rossant (The Hospital for Sick Children, University of Toronto, Canada) addressed how cells transition from totipotency to pluripotency in the early embryo. Pointing out that the ...
6
A review paper on stem cells
... for these complications, careful monitoring of the number of developing follicles, and adjusting the dose of human chorionic gonadotropin administered to induce ovulation or canceling the cycle (National Research Council ...
8
Cord Blood: A Review
... of cells for ...pluripotent stem cells from cord cells and to optimize techniques to generate hematopoietic lineages from ...new cells, for additional therapeutic applications, ...
16
Characterization and Therapeutic Application of Mesenchymal Stem Cells with Neuromesodermal Origin from Human Pluripotent Stem Cells
... progenitor cells (NPC) with spinal cord identity, differentiated cells at D2 were subjected to dual SMAD inhibitor treatment (dSMADi; SB431542 and noggin) together with an RA regime ...that cells in ...
15
In vivo modelling of normal and pathological human T-cell development
... Supplementary Figure 1: Spike-in experiments to calibrate the DNA barcoding method. A plasmid sample was spiked in at equimolar ratio and diluted into a bulk barcoded sample. A) The bargraph shows the measured fraction ...
91