hepatic gluconeogenesis
Anti-diabetic effect of sorghum extract on hepatic gluconeogenesis of streptozotocin-induced diabetic rats
... Our study had a few limitations. We did not measure the active components in the 80% ethanol extract of sor- ghum or determine whether the protein expression was due to a change in mRNA levels. We also did not ob- serve ...
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Ginsenoside Rg1 Inhibits Glucagon-Induced Hepatic Gluconeogenesis through Akt-FoxO1 Interaction
... for hepatic glucose output, and found that HFD-fed mice showed higher blood glucose in response to pyruvate load (Figure ...blocking hepatic gluconeogenesis [23], demonstrated a similar regulation as ...
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MAPK phosphatase–3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice
... Conversely, shRNA knockdown of MKP-3 in both lean and obese mice resulted in decreased fasting blood glucose levels. In vitro experiments identified forkhead box O1 (FOXO1) as a substrate for MKP-3. MKP-3–mediated ...
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Dexamethasone induced Krüppel like factor 9 expression promotes hepatic gluconeogenesis and hyperglycemia
... Increased hepatic gluconeogenesis contributes to hyper- ...mice. Hepatic Klf9 expression was significantly increased in db/db mice compared with that in control mice (Figure 7, A and ...whether ...
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The Role of the Liver X Receptor (LXR) in the Fetal Programming of Hepatic Gluconeogenesis
... of hepatic gluconeogenesis and lipogenesis 34,35 it is important to take into account the nutritional status of the animal in the assessment of its metabolic ...
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Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
... contrast, gluconeogenesis was upregulated in LKB1-deficient ...inhibits hepatic gluconeogenesis in an LKB1- and AMPK-independent manner via a decrease in hepatic energy ...
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Original Article MicroRNA-223 inhibits hepatic gluconeogenesis by targeting forkhead box O1
... The gluconeogenesis pathway was considered as a potential therapeutic target for preventing type 2 diabetes ...in hepatic gluconeogenesis in ...of hepatic gluconeogenesis, and, notably, ...
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Hepatitis C Virus Infection Promotes Hepatic Gluconeogenesis through an NS5A-Mediated, FoxO1-Dependent Pathway
... Chronic hepatitis C virus (HCV) infection is often associated with type 2 diabetes. However, the precise mechanism underlying this association is still unclear. Here, using Huh-7.5 cells either harboring HCV-1b RNA ...
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An in Vitro Model of Post Exercise Hepatic Gluconeogenesis in the Gulf Toadfish Opsanus Beta
... Despite this potentially adaptive stimulation of gluconeogenesis, I estimate, based on observed in vitro rates and in vivo estimates of lactate load, that hepatic gluconeogenesis account[r] ...
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Biologically active, high levels of interleukin-22 inhibit hepatic gluconeogenesis but do not affect obesity and its metabolic consequences
... To explore the mechanisms by which IL-22 reduces blood glucose levels in HFD-fed mice, we performed an in vivo glucose turn-over assay and pyruvate tolerance test (PTT), an assay to determine hepatic ...
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Original Article Cucurbitacin-D inhibits hepatic gluconeogenesis through activation of Stat3 signaling
... Cucurbitacins belong to a class of highly oxi- dized tetracyclic triterpenoids, which are widely distributed in the plant [8]. Recent studies reveal their promising anticancer activities including anti-proliferation, ...
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<p>Resveratrol affects hepatic gluconeogenesis via histone deacetylase 4</p>
... The liver is sensitive to insulin actions, and impaired glu- cose and lipid metabolism in the liver can cause various meta- bolic syndromes such as obesity, insulin resistance, diabetes, and nonalcoholic fatty liver ...
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Regulation of hepatic gluconeogenesis and glycogenolysis by catecholamines in rainbow trout during environmental hypoxia
... A Liver pyruvate kinase activity for series I at 0-2 and 5-0mmoll ' phosphoenolpyruvate PEP concentrations and the ratio of activities at 0-2/5-OPEP and B glycogen phosphorylase activity[r] ...
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Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1α pathway in high-fat-diet-induced rats and insulin resistant cells
... Insulin resistance is a multifaceted disorder that involves the modulation of various genes at the transcriptional and translational levels. The rate of gluconeogenesis is determined by both the availability of ...
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Hepatic Ketogenesis and Gluconeogenesis in Humans
... starvation. Hepatic gluconeogenesis was estimated to be 99 g/24 h, calculated as the sum of lactate, pyruvate, glycerol, and amino acid ...of hepatic ketogenesis and gluconeogenesis was ...
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Antifatigue Effect of Murraya Koenigii
... (35) and the ensuing hypoglycaemia could result in impaired CNS functionality Thus, the maintenance of glycemia during physical activity by hepatic gluconeogenesis a[r] ...
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A REVIEW ON THE ANTI-TUMOR EFFECT OF METFORMIN IN CANCER
... of hepatic gluconeogenesis and the stimulation of glucose uptake in muscle (Hundal et ...in gluconeogenesis in the liver and those encoding glucose transporters in the ...
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PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans
... increased hepatic insulin signaling and reduced expression of gluconeogenic and lipogenic ...of hepatic gluconeogenesis, improved glucose tolerance, and reduced hepatosteatosis with ...developed ...
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Vol 70, No 2 (2018)
... enhanced hepatic insulin signaling and de- creased hepatic glucose ...hanced hepatic the level of IR-1A mRNA and down- regulated the mRNA and protein levels of ...of hepatic ...
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Effects of glucagon on plasma amino acids
... Supporting the hypothesis that glucagon affects amino acid concentrations by altering hepatic gluconeogenesis was our finding that plasma concentrations of those amino acids known to be [r] ...
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