hepatocyte nuclear factor
Studies of genetic variability of the hepatocyte nuclear factor-1α gene in an Indian maturity-onset diabetes of the young family
... transcriptional factor including hepatocyte nuclear factor-4α (HNF-4α)/(MODY1), hepatocyte nuclear factor-1α (HNF-1α)/(MODY3), insulin promoter factor-1 ...
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A review on hepatocyte nuclear factor-1beta and tumor
... The aberrant expression of HNF1 β in tumors is associ- ated with epigenetic processes and epigenetic changes. In humans, one of the epigenetic mechanisms that regulate expression of genes is methylation of the clusters ...
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Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatocyte Nuclear Factor 6
... that hepatocyte nuclear factor 6 (HNF6), a liver-enriched transcription factor, can inhibit HBV gene expression and DNA ...host factor that can restrict HBV replication via both ...
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Defective insulin secretion in hepatocyte nuclear factor 1alpha deficient mice
... transcription factor hepatocyte nuclear factor (HNF) 1alpha cause maturity-onset diabetes of the young (MODY) 3, a form of diabetes that results from defects in insulin ...
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Hepatocyte nuclear factor 1β controls nephron tubular development
... structures. Hepatocyte nuclear factor 1β (HNF1β) is a divergent homeobox transcription factor that is expressed in kidney from the first steps of ...
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Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor 4alpha/MODY1 gene
... the hepatocyte nuclear factor(HNF)-4alpha/MODY1, glucokinase/MODY2, and HNF-1alpha/MODY3 genes can cause this form of ...transcription factor in the tissues in which it is expressed, including ...
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Role of hepatocyte nuclear factor 4 alpha in cell proliferation and gemcitabine resistance in pancreatic adenocarcinoma
... Hepatocyte nuclear factor 4α (HNF4α or NR2A1), is an orphan nuclear receptor that is expressed in pancreas, liver, kidney and intestine [5, ...
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Mechanisms of Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by Hepatocyte Nuclear Factor 3β
... factors hepatocyte nuclear factor 4 (HNF4) and the retinoid X receptor ␣ (RXR␣) plus the peroxisome proliferator-activated receptor ␣ (PPAR␣) heterodimer (RXR␣-PPAR␣) that regulate the synthesis of ...
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Mutations in the coding regions of the hepatocyte nuclear factor 4 alpha in Iranian families with maturity onset diabetes of the young
... Hepatocyte nuclear factor 4α (HNF4α) is a nuclear receptor involved in glucose homeostasis and is required for normal β cell ...predisposing factor for developing diabetes in ...
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A missense mutation in hepatocyte nuclear factor 4 alpha, resulting in a reduced transactivation activity, in human late onset non insulin dependent diabetes mellitus
... mouse hepatocyte nuclear factor-1 a ( HNF-1 a ) promoter (PstI 2 1300/NheI 1 157) were cloned in the pBLCAT6 reporter vector to generate the apo CIII-CAT and the HNF-1 a -CAT vectors, ...
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The impact of hepatocyte nuclear factor-1α on liver malignancies and cell stemness with metabolic consequences
... occurrence of liver adenomatosis in six MODY3-affected patients from two unrelated large families, and a hot-spot germline mutation P291fs of HNF-1α was identified in the two pro-bands and 16 relatives from the two ...
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Hepatocyte nuclear factor 1α suppresses steatosis associated liver cancer by inhibiting PPARγ transcription
... growth factor signaling ...growth factor tyrosine kinase receptors and ligands (MET, FGF19, VEGF, and IGF); and its activation was pos- itively correlated with the severity of the disease (5, ...
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A NOVEL MUTATION IN THE HEPATOCYTE NUCLEAR FACTOR-1 Α GENE AMONG MODY EGYPTIAN PATIENTS
... The aim of study was to characterize patients classified as HNF1α-MODY and investigate whether mutation type (missense, nonsense and frameshift), or functional domain of[r] ...
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Hepatocyte Nuclear Factor 3β Inhibits Hepatitis B Virus Replication In Vivo
... The hepatitis B virus (HBV) is a 42-nm enveloped particle possessing an internal 28-nm nucleocapsid (5, 14). The 3.2-kb partially double-stranded circular viral genome and the HBV polymerase are present within the ...
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Alpha-fetoprotein-producing ovarian clear cell adenocarcinoma with fetal gut differentiation: a rare case report and literature review
... for hepatocyte nuclear factor-1 beta (HNF-1 beta), but negative for CD30, making the diagnosis of AFP-producing clear cell type EOC with fetal gut differentiation in focal areas, FIGO (International ...
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Functional interaction of nuclear factors EF-C, HNF-4, and RXR alpha with hepatitis B virus enhancer I.
... The nucleotide sequence of the GB element is similar to the sequences of binding sites of liver-enriched nuclear proteins HNF-4 hepatocyte nuclear factor 4 42 and RXRot retinoid X recept[r] ...
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Induction of an EMT like transformation and MET in vitro
... growth factor (VEGF)-c, hepatocyte nuclear factor 4α (HNF4α), CD147 and Sonic hedgehog-Gli pathway components (SHH, Patch-1 and SMO) in co-cultured Bel-7402 cells, all of which are associated ...
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A complex microdeletion 17q12 phenotype in a patient with recurrent de novo membranous nephropathy
... : Hepatocyte nuclear factor-1 β gene; LHX1: Homeobox transcription factor 1 gene; MN: Membranous nephropathy; MRKH: Mayer- rokitansky-kuester-hauser-syndrome; NODAT: New onset diabetes ...
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Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors
... and nuclear run-on assays demonstrated a marked reduction in ntcp gene ...treatment, nuclear binding activities of two key factors that transactivate the ntcp pro- moter, hepatocyte nuclear ...
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Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus
... The Irs2–/– mice displayed leptin resistance; and a low dose of leptin Nonstandard abbreviations used: Foxo1, forkhead transcription factor 1; Hnf, hepatocyte nuclear factor; βHT-IRS2, β[r] ...
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