Hepatocyte Nuclear Factor-6
Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatocyte Nuclear Factor 6
... that hepatocyte nuclear factor 6 (HNF6), a liver-enriched transcription factor, can inhibit HBV gene expression and DNA ...host factor that can restrict HBV replication via both ...
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Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors
... and nuclear run-on assays demonstrated a marked reduction in ntcp gene ...treatment, nuclear binding activities of two key factors that transactivate the ntcp pro- moter, hepatocyte nuclear ...
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Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor 4alpha/MODY1 gene
... MODY is a phenotypically and genetically heterogeneous form of diabetes mellitus (1). Mutations in the glucokinase/ MODY2 gene are associated with a mild form of diabetes characterized by plasma glucose levels that are ...
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A missense mutation in hepatocyte nuclear factor 4 alpha, resulting in a reduced transactivation activity, in human late onset non insulin dependent diabetes mellitus
... Since the V393I substitution does not result in the gain or loss of a site for a restriction endonuclease, we developed a simplified protocol that would allow us to use a PCR-RFLP as- say to test for its presence (Fig. 1 ...
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Role of hepatocyte nuclear factor 4 alpha in cell proliferation and gemcitabine resistance in pancreatic adenocarcinoma
... Hepatocyte nuclear factor 4α (HNF4α or NR2A1), is an orphan nuclear receptor that is expressed in pancreas, liver, kidney and intestine [5, ...
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The impact of hepatocyte nuclear factor-1α on liver malignancies and cell stemness with metabolic consequences
... Although HNF-1α impacts a wide range of organs, the hepatic responses are most pronounced due to its higher concentration and local production. For instance, it showed hints of effectiveness in NAFLD and hepatic fibro- ...
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A NOVEL MUTATION IN THE HEPATOCYTE NUCLEAR FACTOR-1 Α GENE AMONG MODY EGYPTIAN PATIENTS
... Morita et al., 2015). These included one mutation (I27L) in dimerization domain (exon 1); two mutations (E90V, and E105G) in the DNA binding domain (exon 1); one mutations (S487N) in the transactivation domain (exon 7). ...
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Defective insulin secretion in hepatocyte nuclear factor 1alpha deficient mice
... a 6-h period was similar to that seen in animals from the other two groups, indicating that hyperglycemia failed to induce a prolif- erative b cell response in the ( 2 / 2 ) ...
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Hepatocyte nuclear factor 1α suppresses steatosis associated liver cancer by inhibiting PPARγ transcription
... HNF1α is a novel negative regulator of PPARG expression. Since PPARG transcript levels are induced in H-HCA and in the liver tis- sue of Hnf1a mouse mutants, we hypothesized that HNF1α might be a novel negative regulator ...
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Activities of stromal and immune cells in HPV-related cancers
... arrest-specific 6; GM-CSF/CSF-2: Granulocyte-macrophage colony- stimulating factor; HGF: Hepatocyte growth factor; HLA: Human leukocyte antigen; HLA-DR: Human leukocyte antigen D related; ...
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Hepatocyte Nuclear Factor 3β Inhibits Hepatitis B Virus Replication In Vivo
... The level of viral replication intermediates and associated cytoplasmic core protein in the liver of the rat HNF3-express- ing HBV transgenic mice was dramatically reduced compared with the control rat HNF3(⫺) HBV ...
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Mutations in the coding regions of the hepatocyte nuclear factor 4 alpha in Iranian families with maturity onset diabetes of the young
... transcription factor 1 (TCF1/MODY3; MIM# 142410) on chromosome 12q [5], insulin promoter fac- tor 1 (IPF1/MODY4; MIM#600733) on chromosome 13q [6], transcription factor 2 (TCF2/MODY5; MIM#189907) on ...
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Mechanisms of Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by Hepatocyte Nuclear Factor 3β
... Expression of truncated HNF3  polypeptides in mouse fi- broblasts. HNF3 has previously been shown to activate tran- scription from the HBV nucleocapsid promoter in reporter gene analysis (37) and to inhibit pregenomic ...
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A review on hepatocyte nuclear factor-1beta and tumor
... (Tissue factor pathway inhibitor 2) are proteases involved in oxidative ...transcription factor 4) and PAX8 (Paired box gene 8) are transcription factors involved in oxidative ...
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Retinoid X receptor alpha transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor.
... Moreover, nuclear receptors exert diverse effects upon cell differentiation, morphogenesis, and carcinogenesis (2, 10, 12, ...(PPAR); hepatocyte nuclear factor-4 (HNF-4); chicken ovalbumin up- ...
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Original Article miR-107 promotes hepatocellular carcinoma cell proliferation by targeting Axin2
... microRNA-141 inhibits cell proliferation and invasion and promotes apoptosis by targeting hepatocyte nuclear factor-3beta in hepatocellular carcinoma cells.. Wnt beta-catenin/Tcf signali[r] ...
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Generation of hepatic spheroids using human hepatocyte-derived liver progenitor-like cells for hepatotoxicity screening
... ADR is a major issue in the pharmaceutical industry as it is responsible for attrition of drugs during development and withdrawal of drugs post-licensing [35]. Among ADRs, drug-induced liver injury (DILI) is the most ...
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Studies of genetic variability of the hepatocyte nuclear factor-1α gene in an Indian maturity-onset diabetes of the young family
... transcriptional factor including hepatocyte nuclear factor-4α (HNF-4α)/(MODY1), hepatocyte nuclear factor-1α (HNF-1α)/(MODY3), insulin promoter factor-1 ...
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Alpha-fetoprotein-producing ovarian clear cell adenocarcinoma with fetal gut differentiation: a rare case report and literature review
... for hepatocyte nuclear factor-1 beta (HNF-1 beta), but negative for CD30, making the diagnosis of AFP-producing clear cell type EOC with fetal gut differentiation in focal areas, FIGO (International ...
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Oligonucleotides targeting coagulation factor mRNAs: use in thrombosis and hemophilia research and therapy
... When factor VIII- deficient hemophilic mice were treated with an siRNA against antithrombin, the hemophilic phenotype disap- peared in a dose-dependent manner without thrombotic ...
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