hepatocyte nuclear factor (HNF)
Original Article Diagnostic value of dual detection of hepatocyte nuclear factor 1 beta (HNF-1β) and napsin A for diagnosing ovarian clear cell carcinoma
... of hepatocyte nuclear factor 1 beta (HNF-1β) and napsin A for diag- nosing ovarian clear cell ...measure HNF-1β and napsin A expression in 38 cases of ovarian clear cell carcinoma, 30 ...
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Studies of genetic variability of the hepatocyte nuclear factor-1α gene in an Indian maturity-onset diabetes of the young family
... transcriptional factor including hepatocyte nuclear factor-4α (HNF-4α)/(MODY1), hepatocyte nuclear factor-1α (HNF-1α)/(MODY3), insulin promoter ...
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A missense mutation in hepatocyte nuclear factor 4 alpha, resulting in a reduced transactivation activity, in human late onset non insulin dependent diabetes mellitus
... V393I HNF- 4 a 2 was generated from the wild-type human HNF-4 a 2 isoform (18) cloned in the expression vector pSG5 using the Stratagene ExSite™ PCR-based site-directed mutagenesis kit according to the ...
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Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor 4alpha/MODY1 gene
... the hepatocyte nuclear factor(HNF)-4alpha/MODY1, glucokinase/MODY2, and HNF-1alpha/MODY3 genes can cause this form of ...and HNF-1alpha genes, mutations in the HNF-4alpha ...
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A review on hepatocyte nuclear factor-1beta and tumor
... The aberrant expression of HNF1 β in tumors is associ- ated with epigenetic processes and epigenetic changes. In humans, one of the epigenetic mechanisms that regulate expression of genes is methylation of the clusters ...
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Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatocyte Nuclear Factor 6
... that hepatocyte nuclear factor 6 (HNF6), a liver-enriched transcription factor, can inhibit HBV gene expression and DNA ...host factor that can restrict HBV replication via both ...
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Mutations in the coding regions of the hepatocyte nuclear factor 4 alpha in Iranian families with maturity onset diabetes of the young
... Hepatocyte nuclear factor 4α is a member of the steroid/ thyroid hormone receptor super family and is expressed in the liver, kidney, small intestine and pancreatic islets ...
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Mechanisms of Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by Hepatocyte Nuclear Factor 3β
... factors hepatocyte nuclear factor 4 (HNF4) and the retinoid X receptor ␣ (RXR␣) plus the peroxisome proliferator-activated receptor ␣ (PPAR␣) heterodimer (RXR␣-PPAR␣) that regulate the synthesis of ...
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Hepatocyte nuclear factor 1β controls nephron tubular development
... structures. Hepatocyte nuclear factor 1β (HNF1β) is a divergent homeobox transcription factor that is expressed in kidney from the first steps of ...
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The impact of hepatocyte nuclear factor-1α on liver malignancies and cell stemness with metabolic consequences
... of HNF-1 at early stages of life can result in hepatic dysfunction and HNF-1- deficient mice died during postnatal life ...a factor in hepatocyte dif- ferentiation from hESC-derived definitive ...
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Defective insulin secretion in hepatocyte nuclear factor 1alpha deficient mice
... (6–11). HNF-1 a is a dimeric homeodomain-containing protein that is expressed in liver, kidney, pancreas, and in the digestive ...of HNF-1 a in mice was shown to be associated with hepatic dysfunction, ...
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Hepatocyte nuclear factor 1α suppresses steatosis associated liver cancer by inhibiting PPARγ transcription
... Figure 4. HNF1α is a novel negative regulator of PPARG gene transcription. (A) Localization of putative HREs in the human PPARG gene. Gray and white rectangles represent noncoding and coding exons, respectively. Black ...
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Retinoid X receptor alpha transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor.
... Moreover, nuclear receptors exert diverse effects upon cell differentiation, morphogenesis, and carcinogenesis (2, 10, 12, ...(PPAR); hepatocyte nuclear factor-4 (HNF-4); chicken ...
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Hepatocyte Nuclear Factor 3β Inhibits Hepatitis B Virus Replication In Vivo
... The hepatitis B virus (HBV) is a 42-nm enveloped particle possessing an internal 28-nm nucleocapsid (5, 14). The 3.2-kb partially double-stranded circular viral genome and the HBV polymerase are present within the ...
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Alpha-fetoprotein-producing ovarian clear cell adenocarcinoma with fetal gut differentiation: a rare case report and literature review
... for hepatocyte nuclear factor-1 beta (HNF-1 beta), but negative for CD30, making the diagnosis of AFP-producing clear cell type EOC with fetal gut differentiation in focal areas, FIGO ...
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Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte like cells
... into hepatocyte-like cells in ...expressed hepatocyte nuclear factor- 3 β (HNF-3 β) , GATA4, cytokeratin 19 (CK19), transthyretin, and α -fetoprotein by day 7, and expressed CK18, ...
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Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors
... and nuclear run-on assays demonstrated a marked reduction in ntcp gene ...treatment, nuclear binding activities of two key factors that transactivate the ntcp pro- moter, hepatocyte nuclear ...
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Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus
... The Irs2–/– mice displayed leptin resistance; and a low dose of leptin Nonstandard abbreviations used: Foxo1, forkhead transcription factor 1; Hnf, hepatocyte nuclear factor; βHT-IRS2, β[r] ...
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Liraglutide downregulates hepatic LDL receptor and PCSK9 expression in HepG2 cells and db/db mice through a HNF-1a dependent mechanism
... Methods: At the cellular level, the expressions of PCSK9 and hepatocyte nuclear factor 1 alpha (HNF1α) protein in HepG2 cells stimulated by liraglutide was examined using Western blot. Seven‑week old ...
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Functional interaction of nuclear factors EF-C, HNF-4, and RXR alpha with hepatitis B virus enhancer I.
... The nucleotide sequence of the GB element is similar to the sequences of binding sites of liver-enriched nuclear proteins HNF-4 hepatocyte nuclear factor 4 42 and RXRot retinoid X recept[r] ...
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