Hereditary Diffuse Gastric Cancer
Merging perspectives: genotype-directed molecular therapy for hereditary diffuse gastric cancer (HDGC) and E-cadherin–EGFR crosstalk
... Hereditary diffuse gastric cancer is a cancer predisposition syndrome associated with germline mutations of the E-cadherin gene (CDH1; ...of gastric cancer, females of 56% ...
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Transcriptomic profiling and quantitative high throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer
... tric cancer [23–25]. For example, patients with meta- bolic subtype of gastric cancer derived from large gene expression profiling of multiple cohorts of clinical gas- tric cancer specimens ...
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Using fruitflies to help understand the molecular mechanisms of human hereditary diffuse gastric cancer
... ABSTRACT Mutations in the CDH1 gene, which encodes the cell adhesion molecule E-cadherin, are associated with hereditary diffuse gastric cancer in humans. Although most of the CDH1 mutations ...
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Therapeutic and prophylactic gastrectomy in a family with hereditary diffuse gastric cancer secondary to a CDH1 mutation: a case series
... of gastric and breast cancer in the ...tric cancer and died of the disease at the age of 49, while his sister died of the same disease at the age of ...likely gastric cancer based on ...
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Genetic screening analysis of patients with hereditary diffuse gastric cancer from northern and northeastern Brazil
... Cytosine hypermethylation in the CpG dinucleotides present within the CDH1 promoter region induces tran- scriptional silencing [45] and might thus explain the lack of E-cadherin immunoreactivity. However, analyses to ...
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A short guide to hereditary diffuse gastric cancer
... As described in section 3.5, progression of intramucosal cancer foci to the submucosa correlates with the acquisition of a poorly differentiated phenotype. Significant numbers of poorly differentiated cells can be ...
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Prophylactic gastrectomy in familial gastric cancer: case report and review of literature
... Gastric cancer is the fourth most common cancer and the second leading cause of cancer ...have hereditary diffuse gastric cancer (HDGC), which is autosomal-dominant ...
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<p>CDH1 (E-Cadherin) Mutation and Gastric Cancer: Genetics, Molecular Mechanisms and Guidelines for Management</p>
... “ Hereditary diffuse gastric cancer, Familial gastric cancer, CDH1 mutation, E-Cadherin, Lobular breast cancer, Prophylactic total gastrectomy ” ...of hereditary ...
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Metastatic tumor evolution and organoid modeling implicate TGFBR2as a cancer driver in diffuse gastric cancer
... In hereditary diffuse gastric cancer (HDGC), germline mutations in CDH1 (that is, E-cadherin) confer a 70% life- time risk of developing diffuse gastric cancer ...of ...
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The Community Rating System: Assessing Indicators of Community Participation, A Dasymetric and Sovi Approach
... for hereditary diffuse gastric cancer made decisions regarding pursuing genetic testing and a prophylactic total ...of cancer, family, the inadequacies of endoscopy surveillance, and ...
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Synchronous appendiceal and intramucosal gastric signet ring cell carcinomas in an individual with CDH1-associated hereditary diffuse gastric carcinoma: a case report of a novel association and review of the literature
... a hereditary cancer syndrome that predis- poses to malignancies of similar morphology at differ- ent ...of gastric signet ring cell carcinoma, metastasizing to the appendix, mimick- ing a primary ...
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Lobular breast cancer: molecular basis, mouse and cellular models
... and diffuse gastric cancer ...the hereditary DGC syndrome [10] and ILC belongs to the tumor spectrum in these patients ...without gastric cancer are also increasingly recognized ...
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Hereditary risk factors for the development of gastric cancer in younger patients
... for gastric cancers have been explored in a number of previous studies, including genetic factors such as blood ...between gastric cancer and blood type A, supporting the view that genetic factors ...
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A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: A case control study in an Italian population
... the gastric mucosal surface [3], DGC is usually diagnosed at an advanced stage and consequently associated with a poorer outcome ...to hereditary DGC [8] consistent with an initiating func- tion of ...
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Familial gastric cancer: detection of a hereditary cause helps to understand its etiology
... different gastric regions (antrum, angulus, corpus, fundus, cardia) ...but diffuse GC is difficult to detect at an early and treatable stage since the ...
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Comprehensive diagnostics in a case of hereditary diffuse leukodystrophy with spheroids
... Hereditary diffuse leukodystrophy with spheroids (HDLS) is a rare autosomal dominantly inherited disease that oc- curs in both familial and sporadic forms ...
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Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment
... Results: complete resection rate was 31% (n = 37). 61% (n = 73) of all patients had already distant metas- tases at the time of surgery, 80% of them peritoneal carcinomatosis. Median survival for the whole group was 8 ...
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The genetic basis of Lynch syndrome and its implications for clinical practice and risk management
... colorectal cancer syndrome to be well characterized was called familial adenomatous polyposis (FAP) and was characterized by very early onset, massively prolific develop- ment of colorectal ...colorectal ...
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Dioscin inhibits gastric tumor growth through regulating the expression level of lncRNA HOTAIR
... Gastric cancer tissues were obtained from the Traditional Chinese medicine of Changzhou Hospital (Changzhou, Jiangsu, ...The gastric cancer cell lines HGC-27, MGC803, and SGC7901 and normal ...
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Low frequency of E cadherinalterations in familial breast cancer
... familial cancer, 19 familial breast cancer patients, whose tumours demonstrated loss of heterozygosity (LOH) at the E-cadherin locus, were screened for germline ...breast, gastric and colon ...
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