Herpes Simplex 2 Virus
The Membrane Proximal Region (MPR) of Herpes Simplex Virus gB Regulates Association of the Fusion Loops with Lipid Membranes
... the virus and cell membranes ...loop 2 [FL2], containing H263) changed conformation at low pH; the bulk of the soluble gB(730t) remained unchanged in ...execute virus-cell fu- ...
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Herpes simplex virus infects most cell types in vitro: clues to its success
... Paired immunoglobulin-like type 2 receptor- a (PILR a ) PILR is one of the paired receptor families. It is expressed mainly in immune cells where one receptor in the family has activating function, while another ...
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The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways
... apoptotic genes, including genes encoding members of the cellular FLICE-inhibitory protein (cFILP) family [25], genes of the anti-apoptotic Bcl-2 family [26, 27], and genes of the inhibitor of apoptosis protein ...
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Incorporation of the Green Fluorescent Protein into the Herpes Simplex Virus Type 1 Capsid
... ment of KOS DNA (lane 1); this fragment exhibited a de- creased mobility in K26GFP-1 (lane 2) and K26GFP-2 (lane 3) DNA due to the insertion of the 716-bp GFP coding sequence. In the case of the digestion ...
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The Interaction between the Major Capsid Protein and the Smallest Capsid Protein of Human Cytomegalovirus Is Dependent on Two Linear Sequences in the Smallest Capsid Protein
... of herpes simplex virus type 1 (HSV-1) have indicated that the mature virion capsid of this virus is composed primarily of four viral proteins (5, 10, 12, 13, 16, 19, ...from ...
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Functional Analysis of the Triplex Proteins (VP19C and VP23) of Herpes Simplex Virus Type 1
... The most frequent amino acid insertions were CLNXX, LFKXX, and VFKXX. In addition, insertions MFKXX and FKQXX were detected in some of the transpositions (Tables 1 and 2). The transprimer and restriction enzyme ...
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Epigenetic Repression of Herpes Simplex Virus Infection by the Nucleosome Remodeler CHD3
... Depletion of CHD3 but not the highly related CHD4 nucleo- some remodeler enhances HSV IE gene expression.The family of CHD remodelers consists of nine related members that share do- mains involved in chromatin ...
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The First Immunoglobulin-Like Domain of HveC Is Sufficient To Bind Herpes Simplex Virus gD with Full Affinity, While the Third Domain Is Involved in Oligomerization of HveC
... Complex formation in solution. We previously demon- strated direct binding in solution of HveC(346t) to a mutant form of gD from HSV-1 KOS. We found that gD(⌬290-299t) bound to HveC(346t) with a stoichiometry of ...
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Subassemblies and Asymmetry in Assembly of Herpes Simplex Virus Procapsid
... Drawing primarily on observed features of the procapsid, we propose that the assembly unit (protomer) consists of a triplex surrounded by three MCP subunits and that the T⫽16 procapsid shell is built from 320 copies of ...
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Mechanisms of expression of herpes simplex virus-common surface antigens in clonal cells of a herpes simplex virus type 2-transformed line.
... 420-429 0022-538X/81/050420-10$02.00/0 Mechanisms of Expression of Herpes Simplex Virus-Common Surface Antigens in Clonal Cells of a Herpes Simplex Virus Type 2-Transformed Line KATSUICH[r] ...
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Pangaea and the Out-of-Africa Model of Varicella-Zoster Virus Evolution and Phylogeography
... cella virus is Old World simian varicella virus ...FIG 2 Phylogenetic tree for the family ...HSV-1, herpes simplex virus 1; HSV-2, herpes simplex ...
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Herpes Simplex Virus gD and Virions Accumulate in Endosomes by Mannose 6-Phosphate-Dependent and -Independent Mechanisms
... Substantial fractions of both soluble and membrane-bound forms of gD, expressed with Ad vectors or in HSV-infected cells, were found in late endosomes containing the 275-kDa MPR and in early endosomes containing the ...
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Herpes simplex virus type 2 infection triggers AP 1 transcription activity through TLR4 signaling in genital epithelial cells
... that herpes simplex virus could trigger cellular PPRs to modulate innate immune ...of virus-induced TLR4 expres- sion up-regulation was ...
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Interaction of herpes simplex virus glycoprotein gC with mammalian cell surface molecules.
... plus 2-nitriloacetic acid agarose resin (Qiagen) for possible use in ...polyhedrosis virus) by using Baculogold (Pharmingen) as the source of baculovirus DNA ...
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Role of mannose-6-phosphate receptors in herpes simplex virus entry into cells and cell-to-cell transmission.
... In the absence of gD phosphorylation, HSV produces small plaques on fibroblasts monolayers. Fibroblasts derived from patients with pseudo-Hurler polydystrophy possess very low levels of ...
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Structure-function analysis of soluble forms of herpes simplex virus glycoprotein D.
... Previous studies showed that a mammalian truncated form of gD (gDt) blocked HSV infection in vitro and in vivo (27, 35). Moreover, gDt bound to cell receptors, including the mannose- 6-phosphate receptor (3, 27). The ...
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Quantitation of herpes simplex virus type 1 DNA and latency-associated transcripts in rabbit trigeminal ganglia demonstrates a stable reservoir of viral nucleic acids during latency.
... In Fig. 4 and 5, the HSV DNA copy numbers per 100 cells for p.i. days 5 and 10 are expressed on the histograms, but they were not used in calculating the average copy number for the latency period between p.i. days 20 ...
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Dendritic Cell Autophagy Contributes to Herpes Simplex Virus Driven Stromal Keratitis and Immunopathology
... the virus and downstream pathology. Additionally, HSV-2 is generally more virulent than HSV-1 regardless of the route of infection ...different virus and mouse strains used in this study ...
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Herpes Simplex Encephalitis Occurring During Chemo-Radiotherapy in Nasopharyngeal Carcinoma – A Case Report from Saudi Arabia Khalid Riaz 1, Muhammad M Fareed 1* , Muhammad Shuja 1 Farhan Khalid 1, Mutahir Tunio1 , Rashad Akasha 1and Abdullah Al Amro1
... Herpes simplex virus 1 (HSV-1), also known as herpes virus hominis, is a double stranded DNA virus responsible for acute disseminated primary infections such as ...
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The Fusion Loops of the Initial Prefusion Conformation of Herpes Simplex Virus 1 Fusion Protein Point Toward the Membrane
... mixed 2:1 with a suspension of bovine serum albumin (BSA)-coated 10-nm colloidal gold particles (Aurion, Wageningen, The Netherlands) that served as fiducial markers, and 4- l drops were then applied to ...
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