Herpes Simplex Virus-1
Role of Microvesicles in the Spread of Herpes Simplex Virus 1 in Oligodendrocytic Cells
... ABSTRACT Herpes simplex virus 1 (HSV-1) is a neurotropic pathogen that can in- fect many types of cells and establishes latent infections in the neurons of sensory ...the virus ...
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Roles of M1 and M2 Macrophages in Herpes Simplex Virus 1 Infectivity
... with herpes simplex virus 1 ...factor 1 (CSF-1) DNA prior to ocular infection with HSV-1. Virus replication in the eye, latency in trigeminal ganglia (TG), and ...
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Isolation and Characterization of the Herpes Simplex Virus 1 Terminase Complex
... During herpes simplex virus 1 (HSV-1) infection, empty procapsids are assembled and subsequently filled with the viral genome by means of a protein complex called the terminase, which ...
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Nelfinavir Inhibits Maturation and Export of Herpes Simplex Virus 1
... Nelfinavir (NFV) is an HIV-1 protease inhibitor with demonstrated antiviral activity against herpes simplex virus 1 (HSV-1) and several other herpesviruses. However, the stages ...
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Structural Variability of the Herpes Simplex Virus 1 Genome In Vitro and In Vivo
... Herpes simplex virus 1 (HSV-1) is a human pathogen that leads to recurrent facial-oral lesions. Its 152-kb genome is organized in two covalently linked segments, each composed of a ...
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The UL12 Protein of Herpes Simplex Virus 1 Is Regulated by Tyrosine Phosphorylation
... The herpes simplex virus 1 (HSV-1) UL12 protein (pUL12) is a nuclease that is critical for viral replication in vitro and neuro- virulence in ...
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Herpes Simplex Virus 1 Interaction with Myeloid Cells In Vivo
... and herpes simplex virus 1 (HSV-1) (an alphaherpesvirus) all enter mice via olfactory neurons ...each virus penetrates the epithe- lium and so will encounter subepithelial ...
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Prediction and Identification of Herpes Simplex Virus 1-Encoded MicroRNAs
... by herpes simplex virus 1 (HSV-1), we applied a computational method to screen the complete genome of HSV-1 for sequences that adopt an extended stem-loop structure and display a ...
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Role of Herpes Simplex Virus 1 γ34.5 in the Regulation of IRF3 Signaling
... control IRF3 activity was due to inefficient translation of viral factors that modulate the IFN response and IRF3. First, we examined the abilities of our mutant viruses to block translational shutoff by measuring eIF2 ␣ ...
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Tetherin Restricts Herpes Simplex Virus 1 and Is Antagonized by Glycoprotein M
... against virus replication. In order to establish a productive infection, a virus must evade or suppress a repertoire of restriction factors directed against it by the ...of virus, in this case ...
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Elimination of Mitochondrial DNA Is Not Required for Herpes Simplex Virus 1 Replication
... cine codons, respectively (Fig. 1). The presence of these mutations in the viral genome was confirmed through DNA sequencing (data not shown). Western blot analysis of infected cell extracts using a polyclonal ...
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Herpes Simplex Virus 1 and 2
... of herpes simplex infection depends on the age and immune status of the host, the anatomic site of involvement, and the antigenic virus ...Primary herpes simplex virus ...
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Contributions of Herpes Simplex Virus 1 Envelope Proteins to Entry by Endocytosis
... Inactivation of virions by pretreatment with low pH is a hall- mark of viruses that enter via an acid-dependent mechanism. The infectivity of HSV particles exposed to low pH is irreversibly re- duced (2). Virion gB ...
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A Functional Role for TorsinA in Herpes Simplex Virus 1 Nuclear Egress
... and virus pro- teins, PC6-3 cells were induced with mock treatment or DOX for 14 h and then infected with HSV-1(F) at an MOI of ...in 1⫻ SDS sample buffer (39001; Thermo Scientific) with added  ...
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Herpes Simplex Virus 1 Envelopment Follows Two Diverse Pathways
... of virus particles (8, 35), possibly in con- cert with UL20 (8), UL31, and UL34 (48), and down regulates undesirable fusions of the viral envelope with membranes dur- ing translocation ...
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Role of Cellular Phosphatase cdc25C in Herpes Simplex Virus 1 Replication
... of virus were deter- mined on Vero ...each virus that replicated in murine cells, the yields in infected cdc25C ⫺/⫺ MEF cells were at least 10-fold lower than those obtained from infected cdc25C ⫹/⫹ ...
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Analysis of the Early Steps of Herpes Simplex Virus 1 Capsid Tegumentation
... blotting and immuno-EM). Fourth, these two capsid types were generated by radically different protocols involving very distinct biophysical properties, i.e., density (sedimentation) or shape and mass (gel filtration). It ...
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Roles of p53 in Herpes Simplex Virus 1 Replication
... erpes simplex virus 1 (HSV-1) virions have three morpholog- ically distinct structures: the nucleocapsid, an icosahedral capsid containing the 152-kbp double-stranded DNA viral ge- nome ...
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Nucleolin Is Required for an Efficient Herpes Simplex Virus Type 1 Infection
... delocalization of nucleolin and for the formation of nucleolin granular dots, we analyzed the nucleolin localization by immu- nofluorescence in cells infected with HSV-1 strains defective in specific viral genes. ...
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Comprehensive Characterization of Extracellular Herpes Simplex Virus Type 1 Virions
... herpesvirus 1 (21), were reported and reviewed (55, ...⬍ 1% of total proteins), medium abundance (1 to 4%), high abundance (5 to 10%), and very high abundance ( ⬎ ...
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