Herpes simplex virus DNA replication
Functional order of assembly of herpes simplex virus DNA replication proteins into prereplicative site structures.
... Herpes simplex virus replicates its DNA within nuclear structures called replication ...viral DNA replication is inhibited, viral replication proteins localize to ...
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Herpes simplex virus DNA synthesis at a preformed replication fork in vitro.
... Proteins from herpes simplex virus (HSV)-infected cells were used to reconstitute DNA synthesis in vitro on a preformed replication fork.. The preformed replication fork consisted of a n[r] ...
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Elimination of Mitochondrial DNA Is Not Required for Herpes Simplex Virus 1 Replication
... with herpes simplex virus type 1 (HSV-1) results in the rapid elimination of mitochondrial DNA (mtDNA) from host ...viral replication or the biology of HSV-1 in- ...viral ...
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DNA Sensing-Independent Inhibition of Herpes Simplex Virus 1 Replication by DAI/ZBP1
... Korea DNA-dependent activator of interferon regulatory factor (DAI) acts as a cytosolic B-form DNA sensor that induces type I inter- ...for DNA sensing in certain cell types due to redundancy of the ...
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DNA Mismatch Repair Proteins Are Required for Efficient Herpes Simplex Virus 1 Replication
... 2011 Herpes simplex virus 1 (HSV-1) is a double-stranded DNA virus that replicates in the nucleus of its human host cell and is known to interact with many cellular DNA repair ...
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Mutations That Increase DNA Binding by the Processivity Factor of Herpes Simplex Virus Affect Virus Production and DNA Replication Fidelity
... and DNA replication of a UL42 null mutant on Vero ...with DNA in infected ...control virus expressing wild-type ...virion DNA copies per PFU. These results suggest that herpes ...
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Effects of Exonuclease Activity and Nucleotide Selectivity of the Herpes Simplex Virus DNA Polymerase on the Fidelity of DNA Replication In Vivo
... of DNA replication mediated by wild-type herpes simplex virus type 1 (HSV-1) strain KOS and its polymerase (Pol) mutant derivatives PAA r 5, Y7, and ...HSV-1 DNA Pol can ...
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A Mutation in the DNA Polymerase Accessory Factor of Herpes Simplex Virus 1 Restores Viral DNA Replication in the Presence of Raltegravir
... the replication of four different herpesviruses, herpes simplex virus 1 (HSV-1), HSV-2, HCMV, and mouse cytomegalovi- rus, by 30- to 700-fold, depending on the dose and the virus ...
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Cellular Transcription Factors Enhance Herpes Simplex Virus Type 1 oriS-Dependent DNA Replication
... The herpes simplex virus type 1 (HSV-1) origin of DNA replication, oriS, contains three binding sites for the viral origin binding protein (OBP) flanked by transcriptional regulatory ...
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Proteomics of Herpes Simplex Virus Replication Compartments: Association of Cellular DNA Replication, Repair, Recombination, and Chromatin Remodeling Proteins with ICP8
... the herpes simplex virus 1 (HSV-1) ICP8 single-stranded DNA-binding ...(i) DNA replication or damage repair, including RPA and MSH6; (ii) nonhomologous and homologous ...
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Structures of herpes simplex virus type 1 genes required for replication of virus DNA.
... Recently, a method has been developed to identify regions in the genome of herpes simplex virus type 1 (HSV-1) which contain genes required for DNA synthesis from an HSV-1 origin of DNA [r] ...
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SAMHD1 Restricts Herpes Simplex Virus 1 in Macrophages by Limiting DNA Replication
... HSV-1 replication but not gene expres- ...or DNA replication, we examined in- fections in cells treated with the drug phosphonoacetic acid (PAA), a specific inhibitor of the viral ...of DNA ...
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Herpes Simplex Virus 1 DNA replication and its role in recombination and transcription
... to DNA replication our data shows that gamma2- genes produce a transcription-complex that recruits ...beta-free virus using bacterial artificial chromosomes and complementing them with stably ...
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Herpes simplex virus type 1 recombination: role of DNA replication and viral a sequences.
... During the course of infection, elements of the herpes simplex virus type 1 (HSV-1) genome undergo inversion, a process that is believed to occur through the viral a sequences.. To inves[r] ...
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H2AX phosphorylation and DNA damage kinase activity are dispensable for herpes simplex virus replication
... lytic replication, though recent reports have differed on this point [54, ...viral DNA must recombine by means other than canonical ATM- dependent homologous recombination, perhaps through proteins that can ...
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Role of the Herpes Simplex Virus Helicase-Primase Complex during Adeno-Associated Virus DNA Replication
... To exclude the possibility that the mutants were defective in the assembly of the HSV replication foci, they were also ex- amined in an immunofluorescence colocalization assay. Figure 4 shows that in the presence ...
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Mechanism of inhibition of herpes simplex virus and vaccinia virus DNA polymerases by aphidicolin, a highly specific inhibitor of DNA replication in eucaryotes.
... Double reciprocal plots of the effects of aphidicolin on the polymerization rates of HSV-I (A) and vaccinia virus (B) DNA polymerases or HeLa cell DNA polymerase a (C) in the presence of[r] ...
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Topoisomerase II cleavage of herpes simplex virus type 1 DNA in vivo is replication dependent.
... The inhibitors are useful for tracking the activity of topoisomerase II in vivo and in vitro at the DNA sequence level; although they appear to alter the specificity of cleavage sites to[r] ...
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Herpes simplex virus type 1 gene products required for DNA replication: identification and overexpression.
... As mentioned above, the products of three of the genes required for DNA replication (ICP8, Pol, and UL42) are well-known infected-cell proteins; the products of the other four genes (ULS[r] ...
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Rolling circle DNA replication by extracts of herpes simplex virus type 1-infected human cells.
... circle replication of circular plas- ...viral DNA polymerase, UL42 protein, helicase-primase, and ...circle DNA replication cross-linked to protein has re- vealed the presence in some products ...
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