herpesvirus entry mediator
Herpesvirus entry mediator regulates hypoxia inducible factor–1α and erythropoiesis in mice
... through herpesvirus entry mediator (HVEM), a molecule of the TNF receptor superfamily, pro- moted HIF-1α activity in the kidney and subsequently facilitated renal Epo production and erythropoiesis in ...
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Functional Region IV of Glycoprotein D from Herpes Simplex Virus Modulates Glycoprotein Binding to the Herpesvirus Entry Mediator
... for entry of many HSV strains (26). The gene product, the herpesvirus entry mediator (HveA; formerly HVEM), is a type I integral membrane protein and is a member of the tumor necrosis factor ...
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Localization of a Binding Site for Herpes Simplex Virus Glycoprotein D on Herpesvirus Entry Mediator C by Using Antireceptor Monoclonal Antibodies
... human herpesvirus entry mediator C (HveC), also known as the poliovirus receptor-related protein 1 (PRR1) and as nectin-1, allows the entry of herpes simplex virus type 1 (HSV-1) and HSV-2 ...
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The role of herpesvirus entry mediator as a negative regulator of T cell–mediated responses
... In addition to the B7 family, some TNF superfamily mem- bers can also play a costimulatory role in T cell activation (1, 2). LIGHT (TNFSF14), a newly identified costimulatory ligand, is predominantly expressed on ...
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Herpesvirus Entry Mediator and Nectin-1 Mediate Herpes Simplex Virus 1 Infection of the Murine Cornea
... for entry to take ...receptors herpesvirus entry mediator (HVEM) and nectin-1 are the primary entry receptors for HSV-2 in the mouse vagina and ...
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Role of Nectin-1 and Herpesvirus Entry Mediator as Cellular Receptors for Herpes Simplex Virus 1 on Primary Murine Dermal Fibroblasts
... during entry is the attachment of virions to glycosaminogly- cans, which facilitates the interaction with cellular receptors, lead- ing to the fusion of the viral envelope with a cellular ...mediating entry ...
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Characterization of Sex Differences in Ocular Herpes Simplex Virus 1 Infection and Herpes Stromal Keratitis Pathogenesis of Wild-Type and Herpesvirus Entry Mediator Knockout Mice
... that herpesvirus entry mediator (HVEM), a mem- ber of the TNF superfamily, has immunomodulatory functions and promotes ocular HSV-1 pathogenesis independently of viral entry receptor functions ...
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HveA (Herpesvirus Entry Mediator A), a Coreceptor for Herpes Simplex Virus Entry, also Participates in Virus-Induced Cell Fusion
... (HSV-1) entry, herpesvirus entry mediator (previously designated HVEM but renamed HveA), also mediates HSV-1-induced cell-cell ...for entry, we examined whether the form of virally ...
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Herpesvirus Entry Mediator and Ocular Herpesvirus Infection: More than Meets the Eye
... ocular herpesvirus infections ...Ocular herpesvirus infections can lead to epithelial ulceration of the cornea, uveitis, and retinitis but most commonly cause herpes stromal keratitis, or HSK ...factor, ...
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Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency
... Herpesvirus entry mediator (HVEM) is one of several cell surface proteins herpes simplex virus (HSV) uses for attachment/en- try. HVEM regulates cellular immune responses and can also increase cell ...
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Herpesvirus Entry Mediator on Radiation Resistant Cell Lineages Promotes Ocular Herpes Simplex Virus 1 Pathogenesis in an Entry Independent Manner
... (HSK). Herpesvirus entry mediator (HVEM), a widely expressed tumor necrosis factor (TNF) receptor superfamily member with diverse roles in immune signaling, facilitates viral entry through ...
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Herpes Simplex Virus 1 Latency and the Kinetics of Reactivation Are Regulated by a Complex Network of Interactions between the Herpesvirus Entry Mediator, Its Ligands (gD, BTLA, LIGHT, and CD160), and the Latency-Associated Transcript
... including herpesvirus entry mediator (HVEM) as well as nectin-1, nectin-2, 3-O-sulfated heparan sulfate (3-OS-HS), paired immunoglobulin-like type 2 receptor (PILR ␣ ), nonmuscle myosin heavy chain ...
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Structure-Based Analysis of the Herpes Simplex Virus Glycoprotein D Binding Site Present on Herpesvirus Entry Mediator HveA (HVEM)
... HSV entry generally more subtle than differences in the levels of gD binding? One pos- sible explanation is that the high levels of HveA expression associated with transient transfection may mask differences in ...
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Examination of the Kinetics of Herpes Simplex Virus Glycoprotein D Binding to the Herpesvirus Entry Mediator, Using Surface Plasmon Resonance
... virus entry (25), (iii) soluble HveAt binds specif- ically to gD in purified virus and blocks entry (32, 50), and (iv) soluble truncated gD (gDt) interacts specifically with HveAt in vitro ...
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Herpes Simplex Virus Glycoprotein D Interferes with Binding of Herpesvirus Entry Mediator to Its Ligands through Downregulation and Direct Competition
... HVEM is expressed mainly on cells of the immune system which are not targets of productive HSV infection or latency in vivo, yet clinical isolates of HSV retain the ability to use this receptor (32). However, HSV can ...
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Herpes Simplex Virus Glycoprotein D Can Bind to Poliovirus Receptor-Related Protein 1 or Herpesvirus Entry Mediator, Two Structurally Unrelated Mediators of Virus Entry
... Although these general characteristics of the gD-HveCt in- teraction are shared by the gD-HveAt interaction (36, 53), other aspects of these interactions were not identical. First, ELISA binding curves were different ...
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Generation of Herpesvirus Entry Mediator (HVEM)-Restricted Herpes Simplex Virus Type 1 Mutant Viruses: Resistance of HVEM-Expressing Cells and Identification of Mutations That Rescue Nectin-1 Recognition
... the entry stage. To determine whether the entry block could be due to mu- tations in HVEM, we sequenced PCR-amplified HVEM cDNA from HT29 ...HSV entry-mediating activity of HVEM (14, 46), we ...
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A Role for Herpesvirus Entry Mediator as the Receptor for Herpes Simplex Virus 1 Entry into Primary Human Trabecular Meshwork Cells
... virus entry into these cells, remain ...HSV-1 entry and major entry mediators in TM cells becomes impor- tant for designing novel strategies to prevent ...the mediator(s) of productive HSV-1 ...
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Herpesvirus Entry Mediator HVEM Mediates Cell-Cell Spread in BHK(TK−) Cell Clones
... to entry of free PRV but not to entry by cell-cell ...mediate entry of free HSV-1 into both cell lines, as shown by an increase in the number of b -galactosidase-expressing cells in cultures ...
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Entry Mechanisms of Herpes Simplex Virus 1 into Murine Epidermis: Involvement of Nectin-1 and Herpesvirus Entry Mediator as Cellular Receptors
... Although gD interactions with either HVEM or nectin-1 have been studied extensively in different cell lines, little is known about the receptors that mediate uptake of HSV-1 in vivo at the natural sites of virus ...
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