HGF receptor/c-Met
Failure to ubiquitinate c Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease
... the HGF receptor c-Met to be properly ubiquitinated and subsequently degraded after stimulation by ...for c-Met, was sequestered in the Golgi apparatus with a 3 b 1 integrin, ...
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Coordinate integrin and c Met signaling regulate Wnt gene expression during epithelial morphogenesis
... factor receptor to stimulate Wnt gene expression and thus regulate kidney ...the Hgf receptor c-Met was detected in immortalized collecting duct epithelial cell lines by western ...
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<p>MET Oncogene in Non-Small Cell Lung Cancer: Mechanism of MET Dysregulation and Agents Targeting the HGF/c-Met Axis</p>
... (HGF) receptor, is an oncogene encoding tyrosine kinase ...of MET/HGF axis pathway is involved in the prolifera- tion, survival, invasion, and metastasis of tumor ...9,10 C-MET ...
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Original Article Partial hepatectomy promotes pancreatic regeneration through HGF/Gab1 pathway in db/db mice
... pancreatic HGF expression and Grb2 as- sociated binder 1 (Gab1) activation were also dramatically increased by partial ...of HGF and Gab1, we treated mice with PHA-665752, a specific inhibitor of ...
9
Current Perspective Of Therapies To Gliomas Expressing Hepatocyte Growth Factor
... known receptor c-Met(6- 10). As such, targeting these receptor tyrosine kinase systems is expected to yield substantial improvement in the patient's ...of receptor tyrosine kinase (RTK) ...
6
The clinical and functional significance of c Met in breast cancer: a review
... the HGF/c-Met pathway in mammary devel- opment ...of HGF in primary murine mammary epithelial cells and subsequent transplantation of these cells into the cleared mammary fat pads of mice re- ...
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Humanized anti-hepatocyte growth factor (HGF) antibody suppresses innate irinotecan (CPT-11) resistance induced by fibroblast-derived HGF
... the HGF/c-MET signaling axis in the tumor may indicate the susceptibility of that tumor to show resistance through this pathway ...the c-MET receptor in different cancer cell ...
14
c-Met expression and activity in urogenital cancers – novel aspects of signal transduction and medical implications
... full-length receptor by metalloproteinases such as ADAM-10 and ...membrane-proximal C-terminal fragment (Met-CTF) by presenilin-dependent, regulated, intramembrane proteolysis (PS-RIP) results in an ...
9
Original Article Dynamic expression and localization of c-MET isoforms in the developing rat pancreas
... of c-Met from adult pancreas does not influence beta-cells or glucose homeo- stasis under basic conditions [9, 11, ...of c-Met mediated cyto- kine induced beta-cells death and accelerated the ...
10
The role of HGF/c-MET signaling pathway in lymphoma
... oncogenic c-MET ...the c-MET- epidermal growth factor receptor (EGFR), c-MET- vascular endothelial growth factor receptor (VEGFR), and c-MET-Wnt ...
8
PKG II reverses HGF-triggered cellular activities by phosphorylating serine 985 of c-Met in gastric cancer cells
... factor receptor (VEGFR), platelet derived growth factor receptor (PDGFR) and insulin like growth factor-1 receptor (IGF-1R) ...on c-Met. So, the inhibition and mechanism of PKG II on ...
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Expression of the c-MET, HGF and VEGF biomarkers in intestinal and diffuse gastric cancer in the Brazilian population: a pilot study for the standardization of the quantitative PCR technique
... of c-Met and HGF were not similar in patients, even though there was a receptor and its respective ...expressed c-Met, only seven patients expressed ...tyrosine-kinase ...
8
Linking MLL and the HGF MET signaling pathway in liver cancer
... the HGF-MET pathway. HGF and its receptor, c-MET, are crucial for liver homeostasis, and the pathway is activated during virtu- ally all acute as well as chronic liver pathol- ...
5
MiR-206 inhibits HGF-induced epithelial-mesenchymal transition and angiogenesis in non-small cell lung cancer via c-Met /PI3k/ Akt/mTOR pathway
... them, HGF (also known as scattering factor) activates the c-Met signaling pathway, thereby, increasing the invasive and metastatic potentials of the cells and allowing the survival of cancer cells in ...
15
Focus on the potential role of ficlatuzumab in the treatment of non-small cell lung cancer
... the c-MET gene and aberrations of MET and HGF expression impact on lung cancer prognosis and are involved in resistance to epidermal growth factor receptor (EGFR) inhibitors in ...
8
2. Saeed A. Alwaleedi
... of HGF and its receptor, c-Met, was investigated in isolated non-balding scalp hair follicles, to examine the suggestion that HGF is a possible paracrine factor involved in hair ...that ...
12
Activation of MET pathway predicts poor outcome to cetuximab in patients with recurrent or metastatic head and neck cancer
... the HGF/MET pathway—that may function as a compensatory route—has been reported in some other tumors [19, 38], but the first description of MET overexpression in HNSCC patients [39] was pub- lished ...
13
Correlations of microvascular blood flow of contrast-enhanced ultrasound and HGF/c-Met signaling pathway with clinicopathological features and prognosis of patients with hepatocellular carcinoma
... of HGF were reduced, and mRNA and protein expressions of c-Met level were increased in the HCC tissues, both of which were closely correlated with clini- copathological features and prognosis of HCC ...
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Original Article HGF/MET signaling promotes glioma growth via up-regulation of Cox-2 expression and PGE2 production
... levels. MET, a hepatocyte growth factor (HGF) receptor, is also frequently high expressed in glioma, which pro- motes glioma growth and ...that HGF/MET signaling can promote PGE2 ...
8
Met tyrosine kinase inhibitor, PF-2341066, suppresses growth and invasion of nasopharyngeal carcinoma
... the HGF/Met impact on invasion and metastasis of ...that Met expression in NPC primary tumors and metas- tases have significant differences, which implies that HGF/ Met pathway may play ...
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