Hh signaling pathway
Original Article Expression of hydrogen sulfide synthases and Hh signaling pathway components correlate with the clinicopathological characteristics of papillary thyroid cancer patients
... the Hh signaling pathway (SHH, PTCH, and SMO) was performed on sections of 10%-neutral-formalin-fixed, par- affin-embedded (FFPE) thyroid tissue that were of 2 µm ...
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<p>SPOP Regulates The Biological Mechanism Of Ovarian Cancer Cells Through The Hh Signaling Pathway</p>
... The Hh pathway exhibits elevated expression in ovarian ...the Hh pathway, and as a transcription factor, it can regulate a variety of genes involved in cell proliferation, cell cycle, and ...
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Therapeutic potential of hedgehog signaling pathway agonist
... (Hh) signaling pathway plays an integral role incorrect tissue patterning of a variety of different cell types during embryonic ...three Hh proteins Sonic (Shh), Indian (Ihh), and Desert (Dhh) ...
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Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy
... the Hh signaling pathway in CRC can be concluded by the following aspects: 1) different types of CRCs and CRC cells exhibit different expressions of components in the Hh signaling ...
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Fine tuning of Hh signaling by the RNA binding protein Quaking to control muscle development
... the pathway? Among the different Hh signaling pathway members available in the zebrafish Ensembl database, only gli2a exhibits a canonical ...the Hh pathway by Qk-gli interaction ...
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Original Article Partial hepatectomy promotes implanted mouse hepatic tumor growth by activating hedgehog signaling
... hedgehog signaling (Hh) in the growth of implanted hepatic tumors after partial hepatectomy (PH) in ...compared. Hh related proteins and downstream cytokine VEGF were tested by Western blot and ...of ...
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<p>The Hedgehog signal transducer <em>Smoothened</em> and microRNA-326: pathogenesis and regulation of drug resistance in pediatric B-cell acute lymphoblastic leukemia</p>
... hedgehog pathway, on leukemo- genesis and drug resistance in pediatric ...the Hh signaling pathway in resistance to chemotherapy drugs in this ...
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Hedgehog/Gli1 signaling pathway regulates MGMT expression and chemoresistance to temozolomide in human glioblastoma
... (HH) signaling pathway plays an impor- tant role in the development of central nervous system during embryogenesis [7, ...cal HH signaling pathway starts with binding of one of ...
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Hedgehog pathway inhibition causes primary follicle atresia and decreases female germline stem cell proliferation capacity or stemness
... the Hh signaling pathway, is activated by the Hh signal transduction cascade and promotes stem cell proliferation ...the Hh pathway, and Cyclin D1, one of the Hh ...
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Roles for Hedgehog signaling in adult organ homeostasis and repair
... role HH signaling may play in this process remain to be ...SHH signaling (Loulier et ...canonical HH signaling pathway, however, occurs only at the NSC stage, where it is ...
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SMO PTCH1 GLI1 GLI2 , and GLI3 , were determined in thirty-three
... the HH pathway involves rapid translocation of ...the HH pathway, and GLI family proteins play a critical role in the regulation of HH signaling pathway ...expression, ...
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Targeting glioma stem cells via the Hedgehog signaling pathway
... the Hh signaling pathway plays a pivotal role in the process of embryonic ...of Hh signaling contributes to cancer development, progression, and the processes of cancer invasion and ...
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Hedgehog signaling stimulates the formation of proliferating Müller glia derived progenitor cells in the chick retina
... the signaling pathways that influence de-differentiation, proliferation and neurogenesis is key to harnessing the regenerative potential of ...The Hh signaling pathway may be important to the ...
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... of Hh signaling after Gli over- expression and activation of atypical protein kinase C (aPK- C)-ι/λ (GLI1-positive regulator) can promote BCC devel- opment regardless of the upstream components ...in ...
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Role of canonical Hedgehog signaling pathway in liver
... (Hh) signaling pathway plays an important role in embryonic ...injuries. Hh signaling is required for liver regeneration, regulates capillarisation, controls the fates of hepatic ...
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Hedgehog is required for CySC self renewal but does not contribute to the GSC niche in the Drosophila testis
... Indeed, Hh signaling is an essential regulator of the self-renewal and the number of follicle stem cells, the offspring of which carry out a comparable function to cyst cells by ensheathing germ line cysts ...
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Kif7 regulates Gli2 through Sufu dependent and independent functions during skin development and tumorigenesis
... of Hh target gene expression in Sufu KO keratinocytes showed approximately threefold upregulation of Gli1 and Ptch1, and ...represses Hh signaling in ...how Hh pathway activation is ...
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Hedgehog dependent proliferation drives modular growth during morphogenesis of a dermal bone
... upon Hh signaling, vp edge morphogenesis is regulated independently from other facets of Op ...by Hh signaling along the ventral Op controls two parameters of morphogenesis: vp edge length and ...
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Sonidegib: mechanism of action, pharmacology, and clinical utility for advanced basal cell carcinomas
... noncanonical Hh signaling since these signaling events bypass SMO-dependent signaling (Figure ...downstream Hh signaling molecule antagonist, such as inhibitors for the Gli ...
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Identification of key pathways and genes in <em>TP53 </em>mutation acute myeloid leukemia: evidence from bioinformatics analysis
... Results: GSEA suggested that TP53 mutations were significantly associated with cell differentiation, proliferation, cell adhesion biological processes, and MAPK pathway. In total, 1,287 genes were identified as ...
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