HIF–hypoxia inducible factor
Study protocol: safety and efficacy of propranolol in newborns with Retinopathy of Prematurity (PROP-ROP): ISRCTN18523491
... retinal hypoxia, that increases the stability of inducible a subunit of the transcription factor hypoxia-inducible factor ...(HIF)-1. HIF-1a accumulation leads to ...
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Expression of hypoxia inducible factor 1 alpha and its downstream targets in fibroepithelial tumors of the breast
... epithelial HIF- 1α and CAIX expression is ...epithelial HIF-1 α and CAIX expression are not predictive of ...that HIF-1α and CAIX expression in the epithelium of phyllodes tumors merely reflects a ...
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Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2
... escape. Hypoxia occurs during placenta and tumor development and was shown to activate ...combining hypoxia-mimicking treatment and 5-aza-2’deoxycytidine, a DNA demethylating agent used in anti-cancer ...
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Hypoxia-inducible factor (HIF) network: insights from mathematical models
... work: HIF crosstalk to mTOR and NF κ B in cancer and inflammation. Hypoxia, the cellular condition when oxygen demand exceeds oxygen supply (1) is present in several physiological and pathophysiological ...
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Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain
... of hypoxia-inducible factor 1 alpha (HIF-1α) and subsequent upregulation of vascular endothelial growth factor (VEGF) could contrib- ute further basement membrane damage [8]; (iii) ...
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Original Article Acute exposure to hypobaric hypoxia upregulates the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor
... Thermal Cycler (Bio-Rad Laboratories). Total RNA from serum and liver tissue was isolated using the NucleoSpin RNA II extraction kit (Macherey-Nagel, Dueren, Germany), according to the manufacturer’s instructions. cDNA ...
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Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives
... the HiF hydroxylase system are widely represented across both animal and non-animal ...The HiF hydroxylase system appears to have emerged with the evolution of early animals, coinciding with the convergence ...
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Cellular turnover and expression of hypoxic inducible factor in acute acalculous and calculous cholecystitis
... decreased HIF-1α expression in AAC are not clear. In a murine model, HIF expression is only sustained for a few hours in a hypoxic environment, implying that factors other than hypoxia are necessary ...
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Hypoxia inducible factor (HIF) as a model for studying inhibition of protein–protein interactions
... from HIF-1a: R1 as Leu818, R2 as Leu822, and R4 as ...selected HIF target genes, VEGFA, LOX, and GLUT1, was assessed using qRT-PCR assays in A549 ...growth factor (VEGFA) by ...of HIF-1a, is a ...
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Hypoxia inducible factor–2 (HIF 2) regulates hepatic erythropoietin in vivo
... regulate HIF-1α and HIF-2α stability ...the HIF-1α/HIF-2α ratio toward ...of HIF-α degradation by prolyl hydroxylase inhibition appears to preferentially induce plasma Epo levels in ...
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Normalization of Tumor Vasculature by Oxygen Microbubbles with Ultrasound
... inhibited hypoxia inducible factor-1 alpha (HIF-1 α )/vascular endothelial growth factor (VEGF) pathway to improve the morphology and function of tumor ...
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A Correlative Study between CT Perfusion Parameters and Angiogenesis in Rabbit VX2 Liver Tumors
... factors. Hypoxia-inducible factor-1 alpha (HIF-1 α ) is the key regulator of an- giogenesis in hypoxia, which directly and indirectly affects angiogenesis by influencing the expression ...
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Original Article Roles of heat shock protein 70 toward hypoxia-inducible factor 1α (HIF-1α) blockade in newborn rats with hypoxia-induced pulmonary hypertension
... of HIF-1α, ET-1, and iNOS ranged from positive (++) to strongly positive ...of HIF-1α, ET-1, and iNOS ranged from weakly positive (+) to positive ...of HIF-1α, ET-1, and iNOS were all significantly ...
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Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
... growth factor (VEGF) plays a pivotal role in vascular changes in ...of hypoxia-inducible factor (HIF)-1α, VEGF, phosphatidylinositol-3 kinase (PI3K) and phosphorylated-Akt levels, and ...
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Resveratrol Inhibits Hypoxia Induced Vascular Endothelial Growth Factor Expression and Pathological Neovascularization
... inhibited hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) via the PI3K/Akt ...or hypoxia for 16 ...the hypoxia-induced HIF-1α ...
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Studies of hypoxia response and regulation of hypoxia inducible factor HIF 1 in Caenorhabditis elegans
... However, the expression levels of the HIF-1-dependent reporter and HIF-1 target gene K10H10.2 are significantly higher in rhy-1 mutants than in vhl-1 mutants Chapter 3 Figure 5A & C, ind[r] ...
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Novel stromal cell signalling systems in oesophageal cancer
... "Expression of hypoxia-inducible factor HIF-1alpha is associated with vascular endothelial growth factor expression and tumour angiogenesis in human oesophageal squamous cell carcinoma."[r] ...
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Energy metabolism and rheumatic diseases: from cell to organism
... [37]. HIF target genes promote erythropoiesis, angiogenesis and Figure ...to hypoxia and reduced nutrient ...arrest. Hypoxia induces hypoxia inducible factor (HIF) ...
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... intermittent hypoxia in OSAHS identified two molecular pathways: A nuclear factor-κB (NF-κB)-dependent inflammatory pathway, which produces inflammatory cytokines, and hypoxia-in- ducible ...
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Hypoxia down-regulates expression of secretory leukocyte protease inhibitor in bronchial epithelial cells via TGF-β1
... to hypoxia, cells respond by up- regulating a number of genes, mainly through the hypoxia- inducible factor (HIF) ...during hypoxia [21]. It has been reported that HIF-1α ...
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