High Mobility Group Box 1
Serum High Mobility Group Box 1 as a Biomarker and a Therapeutic Target during Respiratory Virus Infections
... ABSTRACT Host-derived “danger-associated molecular patterns” (DAMPs) contrib- ute to innate immune responses and serve as markers of disease progression and severity for inflammatory and infectious diseases. There is ...
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Investigations into the interactions of the high mobility group box 1 protein and their toxicological relevance
... with high morbidity and mortality ...The High Mobility Group Box 1 (HMGB1) protein is an important inflammatory mediator which alters the immune system to tissue stress and ...
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High expression of high mobility group box 1 (hmgb1) predicts poor prognosis for hepatocellular carcinoma after curative hepatectomy
... High mobility group box 1(HMGB1), an evolutionarily ancient protein, is a nuclear DNA-binding protein that loosely binds to chromatin and presents in almost all eukaryotic cells ...
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Role of high-mobility group box 1 in patients with acute obstructive suppurative cholangitis-induced sepsis
... High-mobility group box 1 (HMGB1) is a chromatin-binding protein that is normally located predominantly inside the nucleus of ...
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Redox Modification of Cysteine Residues Regulates the Cytokine Activity of High Mobility Group Box-1 (HMGB1)
... High mobility group box 1 (HMGB1) is a nuclear protein with extracellular inflammatory cytokine ...thiol group and a disulfide bond between C23 and C45, whereas the inactive form ...
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High mobility group box 1 is involved in the initial events of early loss of transplanted islets in mice
... that high-mobility group box 1 (HMGB1) plays a crucial role in the initial events of early loss of transplanted islets in a mouse model of ...
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Original Article The role of high mobility group box 1 (HMGB-1) in the diabetic retinopathy inflammation and apoptosis
... blindness. High mobility group box 1 (HMGB-1) is considered to be an inflammatory mediator in the late phase that promotes inflammation and neovascularization in ...
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Neuroinflammation in Autism Spectrum Disorders: the Role of High Mobility Group Box 1 Protein
... The high mobility group box-1 protein (HMGB1) is an inflammatory marker which has been shown to play a role in inducing and influencing ...
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Role of high-mobility group box 1 in methamphetamine-induced activation and migration of astrocytes
... Background: Mounting evidence has indicated that high-mobility group box 1 (HMGB1) is involved in cell activation and migration. Our previous study demonstrated that methamphetamine ...
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Renal Expression and Clinical Significance of High Mobility Group Box 1 in Lupus Nephritis
... of high mobility group box 1 (HMGB1) expression in nephridial tissues of lupus nephritis ...assessment group (BILAG) ...had high renal disease activity (BILAG ...
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Bench to bedside review: High mobility group box 1 and critical illness
... (ERK) 1/ERK2 mitogen-activated protein kinase (MAPK)- or PKC (protein kinase C)-dependent signaling but is inhibited by treating the cells with wortmannin, an inhibitor of PI3K (phosphatidyl ...of ...
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Molecular isoforms of high mobility group box 1 are mechanistic biomarkers for epilepsy
... (4). High-mobility group box 1 (HMGB1), a prototypical member of the DAMP fam- ily, is a known mediator of sterile neuroinflammation evoked by epileptogenic injuries (4, ...
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High Mobility Group Box 1 and Traumatic Brain Injury
... High Mobility Group Box 1 (HMGB1) is extremely preserved structure in various species and primitively known as a nuclear DNA-binding protein that takes part in the formation of ...
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The Role of High Mobility Group Box 1 in Innate Immunity
... studies. High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that is implicated in various aspects of the innate immune system as a damage-associated molecular pattern ...
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High Mobility Group Box 1 expression predicts survival of patients after resection of adenocarcinoma of the ampulla of Vater
... of High-Mobility Group Box 1 (HMGB1), a multifunctional protein involved in DNA function as well as cell proliferation, inflammation, and the immune response, has been reported to be ...
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Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases
... grade and distant metastases of liver cancer, and knockdown of HMGB1 in- hibits liver cancer growth and metastasis (75,76). Serum HMGB1 levels were sig- nificantly higher in HCC and HBV pa- tients and were associated ...
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Relationship between high-mobility group box 1 overexpression in ovarian cancer tissue and serum: a meta-analysis
... criteria: 1) evaluated the association between HMGB1 overexpression in tissue and serum with ovarian cancer; 2) evaluated the association between HMGB1 over- expression and ovarian cancer prognosis; 3) used ...
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Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis
... Methods: Thirty-five patients with active LN were included. Renal biopsies were performed at baseline and after standard induction therapy; corticosteroids combined with immunosuppressive drugs. The biopsies were ...
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Overexpression of high mobility group box 1 contributes to progressive clinicopathological features and poor prognosis of human bladder urothelial carcinoma
... IHC, high HMGB1 expression was examined in 84 of 165 (51.0%) BUC cases. High HMGB1 expression was significantly correlated with poorer differentiation and higher T and N classifica- tion (all ...that ...
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High mobility group box 1 potentiates the pro inflammatory effects of interleukin 1β in osteoarthritic synoviocytes
... Louis, MO, USA) and cultured at 37°C in 5% carbon dioxide atmosphere until third passage (95% fibroblasts, detected by immunocytochemistry with anti-collagen I antibody (Chemicon, Millipore Iberica, Madrid, Spain)). ...
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