histone acetyltransferase
Cryptococcus neoformans Histone Acetyltransferase Gcn5 Regulates Fungal Adaptation to the Host
... Gcn5-mediated histone acetyltransferase activity would be an important way for ...that histone acetyl- transferase inhibitors are able to result in temperature sensi- tivity of ...
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The Histone Acetyltransferase CLOCK Is an Essential Component of the Herpes Simplex Virus 1 Transcriptome That Includes TFIID, ICP4, ICP27, and ICP22
... circadian histone acetyltransferase CLOCK, that both proteins localize at ND10 bodies and are stabilized by viral proteins, that enzymatically active CLOCK partially complements ⌬ ICP0 mutants, and that ...
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The histone acetyltransferase inhibitor Nir regulates epidermis development
... that histone acetylation can be present at some genes together with putative repressive histone marks (De Gobbi et ...the histone acetyltransferase p300 and the HDAC SIRT1, increases Foxp3 ...
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3D QSAR and docking studies on benzoylsulfonohydrazides as histone acetyltransferase KAT6A inhibitors
... of histone acetyltransferase (HAT) which are p300, GNAT (Gcn5-related N-acetyltransferase), and MYST (MOZ, Ybf2, Sas2, and Tip60 as founding members) (Voss and Thomas, ...
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Plasmodium falciparum Histone Acetyltransferase, a Yeast GCN5 Homologue Involved in Chromatin Remodeling
... The yeast transcriptional coactivator GCN5 (yGCN5), a histone acetyltransferase (HAT), is part of large multimeric complexes that are required for chromatin remodeling and transcriptional activation. Like ...
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Histone H3K4 and H3K36 Methylation Independently Recruit the NuA3 Histone Acetyltransferase in Saccharomyces cerevisiae
... ABSTRACT Histone post-translational modifications (PTMs) alter chromatin structure by promoting the interaction of chromatin- modifying complexes with ...of histone PTMs. In Saccharomyces cerevisiae , the ...
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Original Article Histone acetyltransferase inhibitor C646 reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells via blocking TGF-β1/Smad3 signaling pathway in vitro
... In the present study, we examined the acetyla- tion of histones (H3 and H4) during high glucose induced EMT of human peritoneal mesothelial cells (HPMCs). Then, chromatin immunoprecipitation followed by qPCR (CHIP- qPCR) ...
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Eaf1 Links the NuA4 Histone Acetyltransferase Complex to Htz1 Incorporation and Regulation of Purine Biosynthesis
... The histone acetyltransferase activity provided by NuA4 is required for the presetting of the inducible PHO5 promoter during the transition from a transcrip- tionally inactive to an active state in the ...
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No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer
... The histone acetyltransferase gene EP300 may function as a tumour suppressor gene because it is sometimes somatically mutated in breast, colorectal, gastric and pancreatic cancers, and is located on a ...
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HIV-1 Resistance to Dolutegravir Is Affected by Cellular Histone Acetyltransferase Activity
... ABSTRACT Integrase strand transfer inhibitors (INSTIs) are the newest class of antiretro- virals to be approved for the treatment of HIV infection. Canonical resistance to these competitive inhibitors develops through ...
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Dissecting The Molecular Basis Of The Scaffold Protein Jade In Hbo1 Histone Acetyltransferase (hat) Activity
... multi-protein histone acetyltransferase (HAT) complexes containing ING4/5, MEAF6 and scaffolding proteins JADE1/2/3 or BRPF2/3 to acetylate histone H4 H4K5/8/12 or H3K14, ...for histone H4 ...
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Original Article Histone acetyltransferase TIP60 mediates spermatozoa damage induced by microwave irradiation in rats
... intragastric administration once a day for 7 days after radiation. On days 1, 2, 7, and 14 after radiation, rat semen/ testis was collected. Sperm motility was measured. Hematoxylin and eosin staining was performed on ...
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The transcriptional cofactor MIER1 beta negatively regulates histone acetyltransferase activity of the CREB binding protein
... MIER1 interacts with CBP. (A) Schematic illustrating the CBP protein sequence and its domains: NR = nuclear recep- tor interaction domain, C/H1 and C/H3 = cysteine/histidine rich regions, KIX = kinase-induced interacting ...
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Histone acetyltransferase inhibitor II induces apoptosis in glioma cell lines via the p53 signaling pathway
... Histone acetyltransferase inhibitor II (HATi II) is a novel cell-permeable bis-arylidene cyclohexanone com- pound that acts as a p300/CBP-selective HAT inhibitor, which can reduce histone H3 ...
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The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats
... by histone deacetylases and an intrinsic histone acetyltransferase (HAT), p300 (12, ...acetylates histone to promote an active chromatin configuration but also is able to acetylate GATA4 and ...
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Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels
... specifically delete Kat8 in oocytes. Oocyte Kat8 deletion resulted in female infertility, with follicle development failure in the secondary and preantral follicle stages. RNA-seq analysis revealed that Kat8 deficiency ...
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Epigenetic Regulation of Axonal Growth of Drosophila Pacemaker Cells by Histone Acetyltransferase Tip60 Controls Sleep
... a histone acetyltransferase (HAT) enzyme that epigenetically regulates genes enriched for neuronal functions through interaction with the amyloid precursor protein (APP) intracellular ...
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Histone Acetylation Level and Histone Acetyltransferase/Deacetylase Activity in Ejaculated Sperm from Normozoospermic Men
... nuclear histone acetylation level and total histone acetyltransferase (HAT) and deacetylase (HDAC) activity in ejaculated sperm and their relevance to conventional sperm ...
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Epigenetic change in kidney tumor: downregulation of histone acetyltransferase MYST1 in human renal cell carcinoma
... for histone H4 acetylation at lysine 16 in both Drosophila and human cells ...of histone H4K16. In this study, we investigated the expression of histone acetyltransferase hMOF and its ...
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An H4K16 histone acetyltransferase mediates decondensation of the X chromosome in C. elegans males
... of histone acetyltransferases ...different histone acetyltransferases (HATs), MYS-1, MYS-2, MYS-4 and ...family histone acetyltransferases [35], and CBP-1 is an unrelated HAT, the homolog of mam- ...
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