Histone H3 lysine 9
Lysine specific demethylase 1 mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes
... -induced histone H3 lysine 9 demethylation and microsomal prostaglandin E synthase 1 protein ...dimethylated histone H3 lysine 9 ...
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KDM3A mediated demethylation of histone H3 lysine 9 facilitates the chromatin binding of Neurog2 during neurogenesis
... the histone H3 lysine 9 demethylase KDM3A facilitates the Xenopus Neurog2 (formerly known as Xngnr1) chromatin accessibility during neuronal ...active histone marks, including H3K27ac ...
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The fungus Neurospora crassa displays telomeric silencing mediated by multiple sirtuins and by methylation of histone H3 lysine 9
... The simple structure of Neurospora subtelomeres facili- tated our strategy to insert selectable markers near Neu- rospora telomeres. For Tel VR, we chose to insert a copy of hph within a Pogo transposon relic found ...
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Functional Redundancy of Variant and Canonical Histone H3 Lysine 9 Modification in Drosophila
... Additionally, histone expression was similar across all genotypes, suggesting that variation in his- tone levels does not underlie observed phenotypes (Figure S7A in File ...
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Regulation of histone H3 lysine 9 methylation in oocytes and early pre implantation embryos
... and H3/K9 methylation, and have suggested that DNA methylation acts downstream of H3/K9 methylation (Tamaru and Selker, 2001; Gendrel et ...and H3/K9 methylation, male pronuclei were transferred into ...
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Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b
... of histone H3 lysine 9 dimeth‑ ylation (H3K9me2) in naïve ES ...other histone methylation marks analyzed, as measured by western blot, immunofluorescence and mass ...the histone ...
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Methylation of Histone H3 Lysine 36 Is Required for Normal Development in Neurospora crassa
... Histone methyltransferase assays. A 1.1-kb fragment coding for the first 372 amino acids of N. crassa SET-2 was amplified from DNA pools of an N. crassa conidial cDNA library (31) with primers SET2–20 and SET2–21, ...
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Experimental acute lung injury induces multi organ epigenetic modifications in key angiogenic genes implicated in sepsis associated endothelial dysfunction
... lysines 9 and 14 of histone H3 (H3KAc) in Matrix ChIP assay to assess changes in this transcrip- tionally permissive modification ...ALI-sepsis-induced histone H3 lysine ...
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Histone H3 lysine K4 methylation and its role in learning and memory
... A major consideration in drugging the methylome, however, is onset of pathology causing cognitive impair- ment—whether cognitive deficits are due to impaired neurodevelopment or impaired plasticity in the devel- oped ...
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Dot1l expression predicts adverse postoperative prognosis of patients with clear-cell renal cell carcinoma
... post-translational histone modification has become more and more popular in cancer research due to their ability to regulate gene ...groups, histone methylation is the first identified post-translational ...
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HDAC is indispensable for IFN-γ-induced B7-H1 expression in gastric cancer
... of histone H3 lysine 27 (H3K27Ac) in the gene promoter region is a marker of active gene transcription ...linking histone acetylation directly to the B7-H1 gene regulation ...
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Establishment of Murine Cytomegalovirus Latency In Vivo Is Associated with Changes in Histone Modifications and Recruitment of Transcriptional Repressors to the Major Immediate-Early Promoter
... of histone modifications change when latency is ...histones H3 and H4 bound to the MIEP are acetylated at lysine residues associated with active transcription and H3 is methylated at ...
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Histone H3 Lysine 4 Methylation Marks Postreplicative Human Cytomegalovirus Chromatin
... (protein lysine methyltransferase) might be specifically recruited to viral replication compartments during or following DNA ...predicted lysine methyltransferase proteins are encoded by the human ge- nome ...
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Cytosolic acetyl-CoA promotes histone H3 lysine 27 acetylation in Arabidopsis
... SALK_051832C (hac7), and SALK_042287 (gcn5) were obtained from the Arabidopsis Biological Resource Center (ABRC) at the Ohio State University. All used Arabidopsis seeds are in Col-0 (Columbia) background, except acc1-4 ...
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Characterization of the grappa Gene, the Drosophila Histone H3 Lysine 79 Methyltransferase
... a histone methyltransferase that modifies the lysine (K)79 residue of histone ...early histone H3 K4 and K9 methylation patterns, the appearance of methylated K79 during embryogenesis ...
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Epigenetic Cross Talk between DNA Methylation and Histone Modifications in Human Cancers
... affect histone-DNA interactions as well as N-terminal ...Since lysine methylation is more stable than other modifications, there has been until recently, discussion as to why stably methylated ...
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Targeting FBPase is an emerging novel approach for cancer therapy
... and breast cancer or FBP2 expression in gastric cancer increased apoptosis by reducing the Bax/Bcl-2 ratio, induc- ing poly ADP-ribose polymerase (PARP), caspase-3 and caspase-9 activation and suppressing ...
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Epigenetic regulation of caloric restriction in aging
... effects. Lysine residues on histones can be mono-, di- or trimethylated, and either activation or repression is dependent upon the particular lysine residue that is modified ...that histone ...
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Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing
... Over the past 15 years, it has been contentious whether H3K9 methylation is enriched on the mouse inactive X, and even in species where H3K9 methylation has been accepted to accumulate on the Xi, its role has remained ...
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Histone and DNA methylation control by H3 serine 10/threonine 11 phosphorylation in the mouse zygote
... Some of our data suggest that the conversion of 5mC into 5hmC is directly linked to the histone phospho- methylation switch model discussed above. The overex- pression of both H3.1/2-GFPS10A and H3.1/2-GFPT11A ...
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