histone modifications
Specific post translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies
... Anti-histone antibodies are found in 70% to 80% of patients with idiopathic SLE [7], and in more than 90% of patients with drug-induced lupus [7,8]. Furthermore, the presence of such antibodies is a highly ...
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Systematic comparison of monoclonal versus polyclonal antibodies for mapping histone modifications by ChIP-seq
... key histone modifications (H3K4me1, H3K4me3, H3K9me3, H3K27ac and H3K27me3) to their polyclonal counterparts, using the same antibodies and lots that had been previously validated by the ENCODE project [1] ...
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Epigenetic histone modifications of human transposable elements: genome defense versus exaptation
... tone modifications are considered for individual TE classes, there are six cases where histone modifications previously identified to be enriched for a given TE class are enriched in the same class ...
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Quantitative proteomic analysis of histone modifications in decitabine sensitive and resistant leukemia cell lines
... Histone modifications, on the other hand, provide another layer in modulating DNA replication and gene ...Linker histone H1; and (2) Core histones (H2A, H2B, H3, and H4) [14, ...chemical ...
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Alternative splicing links histone modifications to stem cell fate decision
... Several histone modifications show dynamic changes in alternatively spliced exons and three are strongly associated with ...The histone modification-associated alternatively spliced genes ...
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PIRCh seq: functional classification of non coding RNAs associated with distinct histone modifications
... by histone modification-specific ...known histone tail modifications individually tagged with DNA barcodes, we found that glutaraldehyde crosslinking did not affect anti- body specificity (Additional ...
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A Novel Method to Identify the Combinatorial Effects of Histone Modifications Based on Rough Set Theory
... include histone modification, gene expression, and transcription factor binding activity ...first histone acetylation data analyzed in this paper is from Kurdistani et al (2004)(Kurdistani et ...second ...
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Scharf, Annette (2009): Dynamics of histone modifications. Dissertation, LMU München: Fakultät für Biologie
... the monomethylated mark. Previous studies have shown a cell cycle regulated manner of H4K20 methylation starting in an unmethylated state prior to deposition, followed by an immediate increase of monomethylation and then ...
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Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications
... Importantly, our experiments also demonstrate that KRAB/ KAP1 epigenetic regulation is fully functional within the con- text of episomal DNA. Indeed, the drug controllability of our AAV and IDLV (i) was completely ...
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EPIGENE: genome-wide transcription unit annotation using a multivariate probabilistic model of histone modifications
... Post-translational modifications (PTM) to histones in the form of acetylation, methylation, phos- phorylation, and ubiquitination, play an important role in the transcriptional ...that histone ...
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Identification of novel genes associated with HIV-1 latency by analysis of histone modifications
... of histone modifica- tions may differ according to cell ...of histone modification binding percentage to genome background binding per- centage on each chromosome ...that histone modifications ...
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Regulatory Function of Histone Modifications in Controlling Rice Gene Expression and Plant Growth
... Among histone modifications, histone lysine acetylation appears to be a dynamic reversible switch for inter- conversion between permissive and repressive transcrip- tional states of chromatin ...of ...
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A tale of histone modifications
... with histone pro- teins into chromatin, compacting DNA some ...translational modifications of histones play in regulating nuclear ...core histone modifications and the factors that regulate ...
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The Paf1 Complex Represses ARG1 Transcription in Saccharomyces cerevisiae by Promoting Histone Modifications
... direction, histone H3 K4 methylation and K36 methylation at ARG1 were highest at 3 ⬘ and 5 ⬘ locations, respectively, a his- tone methylation pattern that is opposite of the typical distri- bution (34, 35, 37, 40, ...
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An integrative analysis of post translational histone modifications in the marine diatom Phaeodactylum tricornutum
... of histone H4 (reported only in Toxoplasma [41], al- though not confirmed in an independent study ...same histone. Due to their accessibility, histone tail modifications have been widely ...
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Histone modifications change with age, dietary restriction and rapamycin treatment in mouse brain
... as histone modifications, maybe be involved in brain aging and age- related ...14 histone modifications in brains of a cohort of young (3 months), old (22 months), and old age-matched dietary ...
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Epigenetic Cross Talk between DNA Methylation and Histone Modifications in Human Cancers
... methylation, histone modifications, and the chromatin structure are profoundly altered in human ...and histone modifications appear to be linked to each ...of histone ...
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The tale of histone modifications and its role in multiple sclerosis
... persistent modifications of gene expression in a manner that does not involve the corresponding alterations in DNA ...includes modifications of DNA nucleotides, nucleosomal remodeling, and ...
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Histone modifications and their role in epigenetics of atopy and allergic diseases
... of histone modification and the role of posttranslational histone modifications in the development of allergic diseases, including the immune mechanisms underlying this ...methylation, histone ...
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Histone modifications and traditional Chinese medicinals
... As histone modifications and cytosine methylation play a role in the activity of genes, aberration in the pattern of modifications to histones and DNA, called epigenome, can lead to ...inhibit ...
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