Histone post-translational modifications
Proteomic characterization of novel histone post-translational modifications
... described histone acetylation ...of histone post- translational modifications (PTMs), including lysine acetylation, arginine and lysine methylation, phosphor- ylation, proline ...
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PAT-H-MS coupled with laser microdissection to study histone post-translational modifications in selected cell populations from pathology samples
... parallel histone isolations and hPTM analysis from FFPE sections, either stained with hematoxylin and eosin (H&E) with routine staining procedures or left un- stained as a control, using mouse spleen as a ...
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Comprehensive analysis of histone post-translational modifications in mouse and human male germ cells
... certain histone isoforms and PTMs pre- viously identified in male germ cells, including multiple PTMs on the spermatid-specific linker histone H1-like protein (HILS) ...the histone isoform in the ...
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Histone post-translational modifications in frontal cortex from human donors with Alzheimer’s disease
... specific histone-modifying enzymes to serve as drug targets for the treatment of AD, a disease which currently does not have any approved therapies to slow disease progression in ...
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Global turnover of histone post-translational modifications and variants in human cells
... of histone PTMs and nucleosomal structure are the electrostatic interac- tion between the H4 tail with respect to H2A/H2B on the adjacent nucleosome [31], the electrostatic interac- tion between H3K56ac and the ...
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An Assessment of Fixed and Native Chromatin Preparation Methods to Study Histone Post-Translational Modifications at a Whole Genome Scale in Skeletal Muscle Tissue
... the histone mark H3K27me3 is known to be distributed in peaks spanning across broad re- gions, we analyzed the data using epic, a ChIP-seq caller based on the SICER algorithm [20, ...
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DNA Replication in Plants Origins of DNA Replication and Post-translational Histone Modifications During the DNA Synthesis Phase of Arabidopsis thaliana.
... core histone within the nucleosome can be modified. Initial studies of histone modification (Tamaru et ...the histone H3 tail could be methylated or acetylated, the serines phosphorylated, and the ...
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Allosteric regulation of protein 14-3-3ζ scaffold by small-molecule editing modulates histone H3 post-translational modifications
... to histone H3 by recognizing its phosphorylation site, but the chemically-induced dimer tends to translocate to the ...from histone H3 leads to the exposure of various modification sites as well as PTMs on ...
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Functional role of post-translational modifications of Sp1 in tumorigenesis
... target genes, which include oncogenes and tumor sup- pressor genes. A recent study demonstrated that both single nucleotide polymorphism (SNP) 285 and SNP 309 in MDM2 (murine double mutant 2) are found in breast cancer ...
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Lysine Post-Translational Modifications of Saccharomyces Cerevisiae Chromatin Proteins
... modified post-translationally and this impacts their functions and in turn, the DNA processes in which they ...of post-translational modifications (PTMs), the enzymes that create and remove ...
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The Regulation of Hippocampal Synaptic Plasticity by Upstream and Downstream Effectors of Histone Acetylation
... Remarks. Post-translational histone modifications – like acetylation, methylation, and phosphorylation – are involved in the activity-induced neuronal gene expression that is essential for ...
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Mutations that prevent or mimic persistent post-translational modifications of the histone H3 globular domain cause lethality and growth defects in Drosophila
... of histone globular domain PTMs also includes three modifications of amino acids that mediate histone–DNA interactions at the nucleosome dyad ...the histone–DNA ...three modifications ...
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Proteomics of protein post translational modifications implicated in neurodegeneration
... with histone acetyltransferases like CREB binding protein CBP and other transcriptional coactiva- tors, thereby promoting target transcription and local translation (confirmed by proteomics [142]) required for ...
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Post translational modifications of HOX proteins, an underestimated issue
... A more indirect way to approach the extent of HOX-associated PTMs is to infer possible PTMs from HOX protein-protein interac- tions involving enzymes mediating PTMs by promoting the covalent addition of functional ...
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Modulation of nucleosomal DNA accessibility via charge-altering post-translational modifications in histone core
... A similar approach was taken for the phosphorylation of the serine and threonine residues. Just as for the other PTMs, we did not explicitly model the phosphate group, but instead, we mimicked the effect of ...
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Developmentally arrested Austrofundulus limnaeus embryos have changes in post translational modifications of histone H3
... days post-fertilization and can persist for months, is characterized by a significant decline in heart rate and an arrest of development and ...the post-translational modifications of ...
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Specific post translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies
... In our own mouse studies, we immunized BALB/c mice with NETs or with NETs combined with CRAMP and expected the mice to develop autoantibodies that recognize specific PTMs present in NETs. Here, we tested the hypothesis ...
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An integrative analysis of post translational histone modifications in the marine diatom Phaeodactylum tricornutum
... and combinatorial analyses revealed some conserved and specific epigenetic features in P. tricornutum, thereby ex- tending the existence of the histone code to Strameno- piles. As expected, both acetylation of ...
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Epigenetic modifications in rheumatoid arthritis
... epigenetic modifications trigger or at least contribute to the characteristic changes of ...epigenetic modifications by showing that treatment with the HDAC inhibitor trichostatin A induces apoptosis in ...
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Event Extraction for Post Translational Modifications
... For further annotation, we aimed to select ab- stracts that contain specific PTM statements iden- tifying both the name of a modified protein and the modified site. As for the initial selection, we fur- ther wished to ...
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