Histone variants: Structure and versatility of function
Bönisch, Clemens (2012): Structure/function analyses of mammalian histone H2A and H3 variants. Dissertation, LMU München: Fakultät für Biologie
... This work comprises three original papers all dealing with histone variants and their biological implications. The centerpiece is the identification and characterization of H2A.Z.2.2 (Z.2.2), a novel, ...
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Type IV secretion systems: versatility and diversity in function
... Institute of Structural and Molecular Biology, UCL and Birkbeck, Malet Street, London WC1E 7HX, UK. cmi_14991203..1212 Summary Type IV secretion systems (T4SSs) are large protein complexes which traverse the cell enve- ...
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Structure-Function Analysis of the Conserved Histone Chaperone Spt6
... chromatin structure, is conserved throughout ...to function in many aspects of gene expression, including nucleosome assembly, transcription initiation and elongation, and mRNA processing and ...a ...
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Histone variants: are they functionally heterogeneous?
... of histone H1 knockouts in mice ([36] and ...H1 variants does not affect viabil- ity or ...remaining histone H1 genes resulted in a normal, or near normal, stoichiometry of total H1 histone to ...
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Histone variants in pluripotency and disease
... of histone variants in maintaining pluripotency and how a fuller understanding of the roles played by these variants is required to achieve effective nuclear ...improper histone variant ...
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Histone H3 Variants in Trichomonas vaginalis
... H3 variants (TVAG_185390, TVAG_224460) might serve as a marker of trichomonad centromeres ...H3 variants lack a conserved sequence motif, but their pro- tein sequences share several specific features (1, ...
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Expression and functionality of histone H2A variants in cancer
... their function remains ...understand histone H2A variants, their contribution to normal cellular function and to cancer development and ...H2A variants expression and ...
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HistoneDB 2.0: a histone database with variants an integrated resource to explore histones and their variants
... (H1) histone proteins are responsible for this compaction through the formation of nucleosomes and higher order chromatin ...specific histone variants and histone post-translational modifi- ...
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Dynamic alterations of linker histone variants during development
... linker histone variants on chromatin structure during this review, we realize that H1 may play functional, as well as struc- tural, roles in development which have yet to be ...linker histone ...
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Histone variants: essential actors in male genome programming
... primary function of TH2B could be to generate less stable nucleosomes at the whole genome scale, which would lower the energy necessary for the cells to undertake chromosome-wide (sex chromosome inactivation) and ...
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Conservation and function of the histone methyltransferase Set2
... conserved histone, H4, has not been ...of histone proteins, occurs on all four core histone proteins and has been shown to control many aspects of chromatin structure and ...2007), ...
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Kinetic and Sequence-Structure-Function Analysis of LinB Enzyme Variants with b- and d- Hexachlorocyclohexane
... 1 CSIRO Ecosystem Sciences, Acton, ACT, Australia, 2 CSIRO Center for Materials Science and Engineering, Parkville VIC, Australia, 3 Division of Engineering and Physics, Wilkes University, Wilkes-Barre, Pennsylvania, ...
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Large scale genome wide analysis identifies genetic variants associated with cardiac structure and function
... Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function Philipp S. Wild, 1,2,3 Janine F. Felix, 4 Arne Schillert, 5,6 Alexander Teumer, 7,8 ...
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Global turnover of histone post-translational modifications and variants in human cells
... a histone peptide becomes acetylated than when it is ...epigenetic function, we found that active marks have a significantly faster turnover than silent ...into histone turnover by using tech- niques ...
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Uncovering new functions for histone variants: a role for H2A.Z in silencing retrotransposons
... Among the histone variants that are most extensively studied is the essential and evolutionary conserved variant, H2A.Z. Recent studies have revealed many layers of regulation and complex functions of H2A.Z ...
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Metabolic Regulation of Gene Expression through Differential Histone Acylation: The Regulation and Function of Histone Crotonylation
... of histone lysine acylations have been identified, diverse in both chemical structure and site of modification, it remains unclear how they are functionally distinct from acetylation, the archetypal ...
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Effects of deleterious opsin gene variants on cone photoreceptor. structure, function, and viability. Scott H. Greenwald
... is relatively low given that S cones comprise only ~6% of the cone photoreceptor population (Carroll et al., 2004). Humans and mice were light adapted under standard fluorescent room lighting. In both species, ERGs were ...
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A Novel Approach for Studying Histone H1 Function in Vivo
... and function of histone ...studying histone H1 function in ...dundant histone H1 variants (Godde and Ura 2008; Happel and Doenecke 2009), Drosophila has only one somatic his- ...
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Tissue-specific expression of histone H3 variants diversified after species separation
... packed structure called ...core histone pro- teins H2A, H2B, H3 and H4. Each histone protein has several variants based on amino acid ...three histone clusters on chro- mosome 3, 11 and ...
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Study of dynamics of histone H3 variants and H3 proteolysis during mouse spermatogenesis
... 3 Chapter 1: Introduction 1.1 Definition of epigenetics Deoxyribonucleic acid (DNA) is the macromolecule that consists of a large number of linked nucleotides and is present in nearly all living organisms. DNA stores ...
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