HIV-1 reverse transcriptase inhibitors
Benzophenone Derivatives: a Novel Scaffold as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors
... wild-type HIV-1 at lower than 1 ...wild-type HIV-1, with an EC 50 value of ...these inhibitors were still not quite sensitive to the resistant ...
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2D and 3D QSAR of Benzimidazole Analogues as Novel HIV-1 Non Nucleoside Reverse Transcriptase Inhibitors
... Syndrome; HIV-2; NRTIs/NTRIs: Nucleoside/nucleotide reverse tran- scriptase inhibitors; NNRTIs: Non-nucleoside reverse transcriptase inhibitors; NCE’s: New Chemical Enti- ties; ...
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Potent Inhibition of Human Immunodeficiency Virus Type 1 Replication by Template Analog Reverse Transcriptase Inhibitors Derived by SELEX (Systematic Evolution of Ligands by Exponential Enrichment)
... inhibit HIV-1 RT competitively and are unlikely to inhibit other viral or cellular proteins, they should have little to no toxicity (5, 26, ...of HIV-1 RT resis- tant to DNA aptamers that we ...
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Suppression of Human Immunodeficiency Virus Type 1 (HIV-1) Viremia with Reverse Transcriptase and Integrase Inhibitors, CD4+ T-Cell Recovery, and Viral Rebound upon Interruption of Therapy in a New Model for HIV Treatment in the Humanized Rag2−/−γc−/− Mouse
... of HIV-1 in antiret- roviral-experienced patients treated with tenofovir ...the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with ...
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MOLECULAR DOCKING STUDIES OF A FEW NOVEL PYRIMIDINE DERIVATIVES AS REVERSE TRANSCRIPTASE HIV 1 INHIBITORS
... on HIV-1- reverse transcriptase as a potential therapeutic ...their HIV-1 reverse transcriptase inhibition activities using in-silico ...with HIV-1 ...
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Comparative Analysis of Two Commercial Phenotypic Assays for Drug Susceptibility Testing of Human Immunodeficiency Virus Type 1
... type 1 (HIV-1) isolates from 50 plasma specimens were analyzed for phenotypic susceptibility to licensed reverse transcriptase inhibitors and protease inhibitors by the ...
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Molecular Modeling of Potential Dual Inhibitors of HIV Reverse Transcriptase and Integrase
... As described in the Methods section, 56 (10%) pyridinones were taken from the entire set of 556 molecules using a stratified random sampling strategy (Figure S6 in the Supplementary material). The selected structures ...
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HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors
... and HIV-1 RT ...of HIV-1 RT expressed within bacterial colonies, and isolated two var- iants of recombinant HIV-1 RT bearing the substitutions N255D or N265D, both of which ...
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Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors.
... 4887 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Human immunodeficiency virus type 1 HIV-1-specific pyridinone reverse transcriptase RT inhibitors prevent HIV-1 rep[r] ...
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Evolving uses of oral reverse transcriptase inhibitors in the HIV 1 epidemic: from treatment to prevention
... of HIV, and these could be powerful tools in curbing and reversing the global epi- ...new HIV infections. WHO option B + (life- long ART for pregnant HIV infected women as opposed to limited duration ...
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Inhibitory activity of 9 phenylcyclohepta[d]pyrimidinedione derivatives against different strains of HIV 1 as non nucleoside reverse transcriptase inhibitors
... We are grateful to Dr. Shibo Jiang from the New York Blood Center, NY, for his critical suggestions for this manuscript. We are deeply indebted to the AIDS Research and Reference Reagent Program, NIAID, NIH, for ...
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CURRENT STATUS OF HIV-1 INTEGRASE INHIBITORS
... on HIV integrase catalysis it is difficult to find the exact pharmacophore for its ...and reverse transcriptase (RT) it would be possible to observe anti-integrase ...of HIV integrase ...
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RP UFLC METHOD DEVELOPMENT AND VALIDATION FOR NEVIRAPINE IN BULK DRUG AND DOSAGE FORMS AS AN ANTIHIV AGENT
... to Reverse Transcriptase there by blocks the RNA dependent and DNA dependent DNA polymerase activities by causing the disruption of the enzyme’s catalytic ...treating HIV infections in combination ...
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Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase
... with HIV-1 ...RH inhibitors and the RH active site of HIV-1 RT, crystals of HIV-1 RT were grown in a complex with the NNRTI drug rilpivirine (RPV) ...of ...
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Differential Sensitivities of Retroviruses to Integrase Strand Transfer Inhibitors
... fect HIV-1 replication show divergent activities against other ...Nonnucleoside reverse transcriptase (RT) inhibitors such as nevirapine are highly selective for HIV-1 ...
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Virtual Screening for Novel HIV-Reverse Transcriptase Inhibitors
... like reverse transcriptase, protease, integrase, ...function. Reverse transcriptase is inhibited ...of HIV-RT from PDB database versus chemical compounds from ZINC database using ...
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AN INSIGHT TO STRUCTURAL ANALYSIS OF COUMARINS AS NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
... In the present paper, we are reporting molecular docking and interaction studies of 83 different derivatives of coumarin nucleus with structure of the binding pocket of non nucleoside reverse transcriptase ...
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Impact of Y181C and/or H221Y mutation patterns of HIV 1 reverse transcriptase on phenotypic resistance to available non nucleoside and nucleoside inhibitors in China
... We traced six patients for 47–58 months in Henan Province failing two NRTIs plus one NNRTI [zidovudine (AZT) plus didanosine (ddI) plus nevirapine (NVP)]. They were infected HIV-1 subtype B by blood ...
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Reduced Susceptibility of Human Immunodeficiency Virus Type 1 (HIV-1) from Patients with Primary HIV Infection to Nonnucleoside Reverse Transcriptase Inhibitors Is Associated with Variation at Novel Amino Acid Sites
... study, HIV from 16% of such antiretroviral-naive individuals was shown to have a susceptibility to nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) between ...
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HIV-1 and HIV-2 Reverse Transcriptases: Different Mechanisms of Resistance to Nucleoside Reverse Transcriptase Inhibitors
... virus. Reverse transcriptase (RT) is an enzyme that contains two enzymatic activities, a DNA polymerase that can copy either an RNA or DNA template, and an RNase H, which degrades RNA if the RNA is part of ...
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