HIV-2
Polymorphisms of HIV 2 integrase and selection of resistance to raltegravir
... in HIV-2. AA 34, a Lys in HIV-1, is involved in PIC binding; Arg was found at position 34 in the majority (42/45) of HIV-2 strains, and supported variability to the conserved R34K in 3 ...
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An infectious chimeric human immunodeficiency virus type 2 (HIV-2) expressing the HIV-1 principal neutralizing determinant.
... to HIV-2 V3 peptides have been shown to neutralize HIV-2 viruses in a type-specific fash- ion (4), as observed (24) for ...sequenced HIV-2 viruses are variable, though less ...
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Genomic Sites of Human Immunodeficiency Virus Type 2 (HIV-2) Integration: Similarities to HIV-1 In Vitro and Possible Differences In Vivo
... the HIV-2 integration sites mapped, ...for HIV-2 (P ⫽ 0.9055). In order to examine HIV-2 integration near transcriptional start sites, the proportion of integrations expected to ...
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Transmitted drug resistance, selection of resistance mutations and moderate antiretroviral efficacy in HIV 2: Analysis of the HIV 2 Belgium and Luxembourg database
... against HIV-2 and their impact in the PI- containing or sparing regimens could have influenced the ...in HIV-1, where guidelines recommend the administration of 2 different classes of drug ...
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Structure of an HIV-2 gp120 in Complex with CD4
... unliganded HIV-1 gp120 cores (gray) shows structural similarity. (Right) The SIVmac32H gp120 core from same viewpoint shows several secondary structural elements with different conformations. (B and C) Alignment ...
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Potent Intratype Neutralizing Activity Distinguishes Human Immunodeficiency Virus Type 2 (HIV-2) from HIV-1
... (Table 2) (23, 42, 52). The HIV-2 panel contained five subtype A HIV-2 isolates, where two isolates origi- nated from Guinea-Bissau (GB/1682 and GB/1812) and three isolates originated ...
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Identification of a Human Immunodeficiency Virus Type 2 (HIV-2) Encapsidation Determinant and Transduction of Nondividing Human Cells by HIV-2-Based Lentivirus Vectors
... (HIV-1), HIV-2 is less pathogenic in humans and is amenable to pathogenicity testing in a primate ...an HIV-2 molecular clone that is infectious but apathogenic in macaques was used to ...
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Kinetic studies of HIV 1 and HIV 2 envelope glycoprotein mediated fusion
... of HIV-2 SBL (KF-3; kindly pro- vided by ...codon. HIV-2 ROD/A and HIV-1 IIIB gp120 expression vectors have been described previously ...
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Role of Human Immunodeficiency Virus (HIV)-Specific T-Cell Immunity in Control of Dual HIV-1 and HIV-2 Infection
... and HIV screening, were also tested. HIV testing was performed by HIV-1/HIV-2 enzyme immunoassay (Genescreen, version 2, HIV-1/HIV-2; Bio- Rad) after written ...
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Field Evaluation of a Rapid Human Immunodeficiency Virus (HIV) Serial Serologic Testing Algorithm for Diagnosis and Differentiation of HIV Type 1 (HIV 1), HIV 2, and Dual HIV 1 HIV 2 Infections in West African Pregnant Women
... with HIV type 1 (HIV-1), 8 specimens found on-site to be infected with HIV-2, 71 specimens found on-site to be infected with both HIV-1 and HIV-2, 40 specimens found ...
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Cytopathicity of Human Immunodeficiency Virus Type 2 (HIV-2) in Human Lymphoid Tissue Is Coreceptor Dependent and Comparable to That of HIV-1
... type 2 (HIV-2) is markedly less pathogenic than HIV-1 in ...with HIV-2 exhibit a remarkably slow rate of disease development, and these clinical properties have been attributed ...
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Virological Response to Highly Active Antiretroviral Therapy in Patients Infected with Human Immunodeficiency Virus Type 2 (HIV 2) and in Patients Dually Infected with HIV 1 and HIV 2 in The Gambia and Emergence of Drug Resistant Variants
... on HIV-1; limited work has been done on ...of HIV-2 than of HIV-1 and the restriction of the HIV-2 epidemic mainly to West Africa, where access to treat- ment has been ...for ...
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Dendritic Cells Are Less Susceptible to Human Immunodeficiency Virus Type 2 (HIV-2) Infection than to HIV-1 Infection
... in HIV-exposed DCs was assessed by qPCR with an ABI7900HT machine (Applied Biosystems, Foster City, ...CA). HIV-1 Gag primers and probe were designed against the Los Alamos HIV database as described ...
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Structural Characterizations of the Dimeric Anti-HIV Antibody 2G12 and the HIV-2 Envelope Glycoprotein
... neither HIV-2 SOSVP 4R nor 6R trimers appeared ideal from Western blot and EM results, we pursued a new rationale for construct ...about HIV-2 Env in general, literature was consulted for both ...
155
Comparison of Heterologous Neutralizing Antibody Responses of Human Immunodeficiency Virus Type 1 (HIV-1)- and HIV-2-Infected Senegalese Patients: Distinct Patterns of Breadth and Magnitude Distinguish HIV-1 and HIV-2 Infections
... loads. HIV-1 plasma viral loads were deter- mined using a commercially available assay (Amplicor HIV-1 monitor test, version ...determine HIV-2 viral loads, an in-house real-time PCR viral ...
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Fundamental Difference in the Content of High-Mannose Carbohydrate in the HIV-1 and HIV-2 Lineages
... c.o. HIV-2 gp120 constructs were used to transfect HEK293T cells using the GenJet method (SignaGen Laboratories, Ijamsville, ...gp140, HIV-1 Bal gp120, HIV-1 JRCSF gp120, HIV-1 ...
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HIV-2 as a model to identify a functional HIV cure
... with HIV-1 and HIV-2 has been reported with a prevalence of up to ...of HIV-2 on subsequent incident HIV-1 infection was reported in 1995, and sev- eral studies reported that ...
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Inhibitory Effects of HIV-2 Vpx on Replication of HIV-1
... of HIV-2 CGP, ...and HIV-2 Vpx monoclonal antibody (56), were used, followed by the use of secondary anti-mouse IgG (Sigma-Aldrich, ...
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Predicting the extinction of HIV-2 in rural Guinea-Bissau
... to HIV-2 increases with age [23], but our findings indicate any such effect that exists is ...higher HIV-2 prevalence amongst older ...with HIV-2 [9,10,35], combined with the ...
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HIV 2 Protease resistance defined in yeast cells
... by HIV-2 in yeast cells induces cell death, as previously shown for the HIV-1 homologue ...rhinovirus 2 [20,21], both species belonging to the Picornavidae genus, produce cell growth arrest ...
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