HIV reservoir
Predicting the broadly neutralizing antibody susceptibility of the HIV reservoir
... produce HIV-1 antigens and perturb adaptive immunity in vivo, potentially contributing to the persistent immune activation observed in patients on ART (36, ...the HIV reservoir at a single time point ...
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Viral diversity is an obligate consideration in CRISPR/Cas9 designs for targeting the HIV reservoir
... Modeling reservoir depletion with CRISPR-based therapy We developed a mathematical model to understand the effect of experimentally controllable parameters on res- ervoir depletion with hypothetical weekly dosing ...
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Beyond the replication competent HIV reservoir: transcription and translation competent reservoirs
... the HIV reservoir in ART-treated individuals at the single-cell level ...the reservoir; this represents the cells from ART-treated individuals that spontaneously reactivate the provirus to produce ...
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Maintenance of the HIV Reservoir Is Antagonized by Selective BCL2 Inhibition
... impacts HIV homeostasis in infected lymphoid ...in HIV persistence is derived from an artificial model of HIV latency wherein primary CD4 T cells infected with HIV and transduced with BCL2 in ...
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Differences in inducibility of the latent HIV reservoir in perinatal and adult infection
... enhanced HIV reactivation with the enhanced TILDA is also consistent with the finding by Hosmane et ...of HIV integration on proviral gene expression in perinatal infections ...viral reservoir, ...
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Immuno-modulatory Strategies for Reduction of HIV Reservoir Cells
... of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies, Lancet, 9327 (2002), ...assess HIV-1 integration and 2-LTR circle formation in ...
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Genetically Intact but Functionally Impaired HIV-1 Env Glycoproteins in the T-Cell Reservoir
... infectious HIV following interruption of ART in HIV-infected subjects is the main obstacle for an HIV ...stable reservoir of HIV proviruses integrated in resting memory T cells (3, 4, ...
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HIV reservoirs in vivo and new strategies for possible eradication of HIV from the reservoir sites
... by HIV to all known classes of currently prescribed antiretroviral drugs and the establishment of HIV reservoirs in ...vivo. HIV has a distinct advantage of surviving in the host via both pre-and ...
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Measuring the latent reservoir in vivo
... integrated HIV DNA, which can include a mixture of DNA from cells with dif- ferent HIV integration sites at different distances from an Alu ...detected. HIV- integrated DNA strongly correlated with ...
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HIV evolution and diversity in ART treated patients
... of HIV proviruses into oncogenes or genes that regulate cell growth [16, ...large HIV infected cell clone was the source of persistent viremia and carried an archived, intact provirus that was capable of ...
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Monitoring Integration over Time Supports a Role for Cytotoxic T Lymphocytes and Ongoing Replication as Determinants of Reservoir Size
... integrated HIV DNA accumulation is the individual level of CTL ...slow reservoir growth early on, suggesting strong CTL activity that was lost over ...restrict HIV production to follicular helper CD4 ...
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Histone Deacetylase Inhibitors for Purging HIV-1 from the Latent Reservoir
... to HIV-1- infected ...of HIV-1 mRNA but who succumb to all-cause mortality, particu- larly cardiovascular and renal events ...of HIV-1 ...of HIV-1 expres- sion and inadequate prevention of ...
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Analysis of the Temporal Relationship between Human Immunodeficiency Virus Type 1 Quasispecies in Sequential Blood Samples and Various Organs Obtained at Autopsy
... of HIV-1 seems ...viral reservoir in the body is therefore of the utmost im- ...of HIV-1 in nonlymphoid tissues may be attributed to infected ...of HIV-1 quasispecies. Alter- natively, the ...
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Phylogenetic Evaluation and Molecular Variation of Leishmania major and Leishmania tropica Isolated from Different Parts of Iran
... Laboratory diagnosis of cutaneous leishmaniasis is based on direct smear of lesion exudates and showing the parasites by microscopic examination of stained specimens. When the result of direct method is negative, the ...
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Reservoir cells no longer detectable after a heterologous SHIV challenge with the synthetic HIV 1 Tat Oyi vaccine
... The seven macaques vaccinated with Tat Oyi were included in a SHIV challenge assay called RIVAC spon- sored by the ANRS. The purpose of the RIVAC assay was to compare ten vaccine approaches on five to seven macaques with ...
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Failure of combined antiretroviral therapy intensification with maraviroc and raltegravir in chronically HIV-1 infected patients to reduce the viral reservoir: the IntensHIV randomized trial
... Patients and methods: We randomly assigned for 48 weeks 22 patients to continue their current first line regimen of Truvada® plus Kaletra® or intensify it with Maraviroc and Raltegravir. The primary objective was to ...
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Measuring replication competent HIV 1: advances and challenges in defining the latent reservoir
... to HIV-1 intra-host diversity, internal deletions, and deamina- tion-induced ...of HIV-1 proviruses present in a given ...reduced HIV-1 diversity, such as culture supernatants from QVOA or cells from ...
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1-s2.0-S0092867420302671-main.pdf
... Perversely, the expectation that robust T cell activation would promptly activate expression of all latent proviral genomes was shattered by the demonstration of non-induced proviruses in 2013 (Ho et al., 2013). In a ...
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... model reservoir inflow as a function of meteorological parameters such as precipitation, temperature and ...is reservoir inflow at the three hydropower ...
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Identification and Characterization of HIV 1 Latent Viral Reservoirs In Peripheral Blood
... virus. HIV phenotyping is typically per- formed on the mixture of the two cloned into replication-compe- tent backgrounds, providing a resistance profile that is skewed by cloning of nonfunctional virus ...latent ...
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