HLA antigen class 1
Splice acceptor site mutation of the transporter associated with antigen processing 1 gene in human bare lymphocyte syndrome
... anti–HLA class I monoclonal antibody (Serotec, Kidlington, United Kingdom); rabbit anti-calreticulin antibody (Affinity BioReagents ...Japan); HLA-A24 con- sensus peptide (A24p, YYEEQHPEL; Sawady ...
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Systemic inhibition of myeloid dendritic cells by circulating HLA class I molecules in HIV 1 infection
... MHC class I isoforms, we focused on how these molecules can affect the stimulatory characteristics of myeloid dendri- tic cells which have key roles for the generation of adap- tive immune ...the ...
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HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status
... (melanoma-associated antigen A1), MART-1 (melanoma antigen recognized by T cells), and glycoprotein 100 ...proper HLA class I expression is needed because metastatic cutaneous melanoma ...
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Purification and characterization of a naturally processed hepatitis B virus peptide recognized by CD8+ cytotoxic T lymphocytes
... surface antigen (HBsAg)– and hepatitis B core antigen (HBcAg)–expressing transfectants can serve as targets for MHC class I–restricted cytotoxic T lymphocytes (CTLs) that are generated from both ...
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Activities of stromal and immune cells in HPV-related cancers
... factor; HLA: Human leukocyte antigen; HLA-DR: Human leukocyte antigen D related; HNSCC: Head and neck squamous cell carcinoma; HPV: Human Papillomavirus; hrHPV: High risk HPV; ICAM: ...
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Human leukocyte antigen class 1 genotype distribution and analysis in persons with active tuberculosis and household contacts from Central Uganda
... for HLA class I at the loci A, B and C using OneLambda HLA class I locus A, B and C polymerase chain reaction-sequence specific primer (PCR-SSP) typing kit following the manufacturer’s ...the ...
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Definition of the viral targets of protective HIV 1 specific T cell responses
... on antigen pro- cessing or CTL functions attributed to protease inhibi- tors [34] and avoids overlap between the resistance mutations sites ...downregulate HLA class I in infected cells ...
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Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells
... of antigen via HLA class II in ep- ithelial cells highlight the complexity of endosomal structures in polarized epithelial cells, with distinct apical and basolateral structures that communicate ...
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Soluble HLA-G Inhibits Myeloid Dendritic Cell Function in HIV-1 Infection by Interacting with Leukocyte Immunoglobulin-Like Receptor B2
... specialized class of professional antigen-presenting cells that are responsible for priming and maintaining antigen-specific effector cell responses and regulating immune activation by cytokine ...
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Dendritic Cells and Macrophages Are Productively Infected by Poliovirus
... allow antigen presentation on HLA class I (4, 20) and class II (19) molecules following uptake by unaf- fected cells and to induce stimulation of antigen-specific CD8 and CD4 T ...
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Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing
... functional class II pathway that operates in the absence of g-IFN (and therefore in the absence of Ii and HLA-DM) and requires a relatively high concentration of ...synthesized HLA class II ab ...
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Susceptible and Protective Human Leukocyte Antigen Class II Alleles and Haplotypes in Bahraini Type 2 (Non-Insulin-Dependent) Diabetes Mellitus Patients
... type 1 diabetes is linked to human leukocyte antigen (HLA) class II genes, the HLA association in type 2 (non-insulin-dependent) diabetes is less ...between HLA class II ...
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beta2 Microglobulin mutations, HLA class I antigen loss, and tumor progression in melanoma
... of HLA class I antigen expression by melanoma cell lines Me18105, Me9923, and ...intron 1 of the beta2m gene, deletes 11 bp from the beta2m mRNA creating a shift in the reading ...exon ...
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Lack of HLA class I antigen expression by cultured melanoma cells FO 1 due to a defect in B2m gene expression
... gene. HLA class I antigen expression was reconstituted on melanoma cells FO-1 after transfection with the wild-type mouse B2m gene, thereby confirming the abnormality of the endogenous B2m ...
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HLA class I deficiencies due to mutations in subunit 1 of the peptide transporter TAP1
... most HLA class I heavy chain/β2m complexes are retained in the ER and are unstable at ...exogenous HLA-A–specific pep- tides. HLA-B appeared to be more unstable than HLA-A, probably as ...
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HLA and proteasome expression body map
... classical HLA class I ex- pression compared to other immune ...classical HLA class I (and class II) transcripts highly abundant in lung and small ...classical HLA class I ...
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Genetic determinants of Nef mediated CD4 and HLA class I down regulation differences between HIV 1 subtypes B and C
... and HLA-I down-regulation between consensus B and C Nef sequences were more apparent in cells expressing lower levels of Nef protein ...Table 1 List of mutations introduced into NL4-3, SK68 and ...
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Interaction of the proteins which regulate MHC class II-mediated antigen presentation by antigen presenting cells
... both HLA-DM and HLA-DR3 are pH sensitive and that the interaction between purified DM and DR3/CLIP complex at pH5 was 6- to 7-fold higher than at ...I-Ad class II molecules for ...I-Ad class ...
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Lack of HLA class I antigen expression by melanoma cells SK MEL 33 caused by a reading frameshift in beta 2 microglobulin messenger RNA
... of HLA class I antigen expression by the melanoma cell line SK-MEL-33 is caused by a unique lesion in beta 2-microglobulin (beta ...with HLA class I heavy chains and for its lack of ...
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Increased frequency of antigen specific CD8+ cytotoxic T lymphocytes infiltrating an Epstein Barr virus–associated gastric carcinoma
... of EBV latent genes (11, 14). In our case, immunoblot analysis revealed that only EBNA1 protein was expressed; RT-PCR analysis showed that gene expres- sion was restricted to EBNA1. This expression pattern is essentially ...
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