HLA-DRB1
Meta Analysis of the Association of HLA DRB1 with Anti Citrullinated Protein Antibody Positive and Anti Citrullinated Protein Antibody Negative Rheumatoid Arthritis
... of HLA-DRB1 alleles in anti-citrullinated protein antibody of (ACPA) RA were ...which HLA-DRB1 alleles are associated with ACPA- positive RA and ACPA-negative ...included HLA- ...
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Genetic susceptibility of eight nonsynonymous polymorphisms in HLA DRB1 gene to hepatocellular carcinoma in Han Chinese
... human HLA system plays a central role in anti-virus and tumor defense [10], and the onset and progression of HCC is closely correlated to this system, in particular a key component - HLA class II ...
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Frequency of HLA-DRB1 in Iraqi Patients with Guillain-Barre Syndrome
... using HLA-DRB1 amplification and hybridization kits (SSO HLA type DRB1 plus and Mastermix for HLA type DRB1 Amp plus kits-Innogenetics-Belgium) using automated method by ...
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Analysis of HLA-A, HLA-B and HLA-DRB1 allelic frequencies in tertiary care from Telangana and Andhra Pradesh
... analyse HLA-A, HLA-B and HLA-DRB1 allelic frequencies among renal transplant recipients and their prospective related and unrelated donors attending Nephrology department at KIMS Hospital, ...
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Peptide Microarray-Based Identification of Mycobacterium tuberculosis Epitope Binding to HLA-DRB1*0101, DRB1*1501, and DRB1*0401
... with HLA-DRB1*0101, -DRB1*1502, and -DRB1*0401 may serve as CD4 ⫹ T-cell epitopes and that these peptides could be useful in designing a rational epitope-based vaccine against ...
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Association between HLA-DRB1 alleles polymorphism and hepatocellular carcinoma: a meta-analysis
... (OR);(4) HLA-DRB1 alleles were molecularly typed (high or low resolution level); (5) inclu- sion of patients according to the diagnosis standard of HCC defined in 2002, based on at least one of the follow- ...
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Association of HLA DRB1 amino acid residues with giant cell arteritis: genetic association study, meta analysis and geo epidemiological investigation
... the HLA-DRB1 typing, it is recognised that HLA-DRB1 represents only a small part of the whole MHC and also that not having complete sequence-based four-digit typing may have resulted in some ...
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The HLA DRB1 locus as a genetic component in giant cell arteritis Mapping of a disease linked sequence motif to the antigen binding site of the HLA DR molecule
... demonstrated heterogeneity for the sequence polymorphism of the third hypervariable region (HVR), but homology for the polymorphic residues within the HVR2 of the HLA- DRB1 gene. The GCA patients shared a ...
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Modeling of PTPN22 and HLA DRB1 susceptibility to rheumatoid arthritis
... for HLA-DRB1 (data not shown) The estimated general population allele frequencies are 15%, 6%, 5%, and 74% for E 1 , E 2 , E 3 , and E x , ...ticular DRB1*11 and ...to HLA-DRB1 differed ...
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HLA Class II Profile and Distribution of HLA-DRB1 and HLA-DQB1 Alleles and Haplotypes among Lebanese and Bahraini Arabs
... example, HLA-DRB1, with more than 315 known alleles, and DPB1, with more than 99 alleles (19), represent the most polymorphic protein-encod- ing regions of the human genome (19, ...
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The importance of HLA DRB1 gene allele to clinical features and disability in patients with multiple sclerosis in Lithuania
... the HLA DRB1*15 allele could be associated with ...the HLA DRB1*03 and *04 alleles ...the HLA DRB1*15 allele suggests that immunological changes affecting the prognosis of the ...
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Single-cell RNA expression profiling shows that ACE2, the putative receptor of Wuhan 2019-nCoV, has significant expression in the nasal, mouth, lung and colon tissues, and tends to be co-expressed with HLA-DRB1 in the four tissues
... with HLA-DRB1, which plays a central role in the immune system by presenting peptides derived from extracellular proteins, in the nasal, mouth, lung, and colon tissues at single-cell ...
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Mutations in HLA DRB1*0101 Exon 2 in a Sub-population of Latvia
... of HLA system, which clearly has a critical function in the realization of the immune response, has not yet been fully studied and ...of HLA- DRB1 gene, which is responsible for the creation of a ...
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Comprehensive Analysis of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 Loci and Squamous Cell Cervical Cancer Risk
... Limitations of this study need to be acknowledged. First, the highly polymorphic nature of HLA alleles leads to multiple comparisons and increases the risk of chance associations. We used the Holm’s test, a ...
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Comprehensive Analysis of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 Loci and Squamous Cell Cervical Cancer Risk
... A-B 0101-0801 96 (19.1) 72 (14.7) 0.8 (0.6-1.1) 0301-0702 62 (12.4) 75 (15.3) 1.4 (0.9-2.0) 0201-0702 58 (11.6) 65 (13.3) 1.2 (0.8-1.8) 0201-4001 41 (8.2) 42 (8.6) 1.1 (0.7-1.8) A-Cw 0101-0701 101 (20.1) 81 (16.5) 0.8 ...
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Association of HLA class I and II genes with cutaneous leishmaniasis: a case control study from Sri Lanka and a systematic review
... the HLA genes ...the HLA-DRB1-HLA-DQA1 region, which were common to population groups across different geographical areas and affected by different parasite species (Fakiola et ...
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The impact of HLA DRB1genes on extra articular disease manifestations in rheumatoid arthritis
... for HLA-DRB1/DQB1 typing of patients recruited from the Mayo Clinic was isolated from peripheral blood mononu- clear cells using the DNA Isolation Kit for Mammalian Blood (Roche Applied Sciences, ...
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Organic solvents and MS susceptibilityInteraction with MS risk HLA genes
... of HLA-DRB1*15, absence of HLA-A*02, and ex- posure to organic solvents, was evaluated by quantification of departure from additivity of ...between HLA- DRB1*15, absence of ...
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Susceptible and Protective Human Leukocyte Antigen Class II Alleles and Haplotypes in Bahraini Type 2 (Non-Insulin-Dependent) Diabetes Mellitus Patients
... the HLA association in type 2 (non-insulin-dependent) diabetes is less ...between HLA class II genotypes and type 2 diabetes was examined in adult Bahrainis, an Arab population with a high prevalence of ...
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A Large-Scale Genetic Analysis Reveals a Strong Contribution of the HLA Class II Region to Giant Cell Arteritis Susceptibility
... imputed HLA data with a previously validated imputation method to perform a more comprehensive analysis of this genomic ...the HLA region, with rs477515 representing the highest peak (p ¼ ...of ...
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