HNF-1
![Regulation of HNF-1[alpha] by DCoH and Dyrk 1B: Equilibrium Unfolding Studies of DCoH and Characterization of an Active Dyrk 1B Construct](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
Regulation of HNF-1[alpha] by DCoH and Dyrk 1B: Equilibrium Unfolding Studies of DCoH and Characterization of an Active Dyrk 1B Construct
... with 1 mM isopropyl-β-D-1-thiogalactopyranoside (IPTG), lysed in 50 mM Tris (pH ...NaCl, 1 mM dithiothreitol (DTT) and purified with Glutathione Sepharose 4 Fast Flow resin (Amersham Pharmacia) ...
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Impacts of ezetimibe on PCSK9 in rats: study on the expression in different organs and the potential mechanisms
... Methods: Thirty rats were randomly divided into two groups (n = 15 for each), which were orally administrated with ezetimibe (10 mg/kg/day) or normal saline. Blood samples were obtained at day 3 after orally ...
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The impact of hepatocyte nuclear factor-1α on liver malignancies and cell stemness with metabolic consequences
... decreased HNF-1α/FXR signaling ac- tivity, which reduces hepatic bile acid excretion and raises the chances of liver damage ...of HNF-1 is achieved a decade ...by HNF-1. Loss of ...
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Hepatitis C Virus NS5A Protein Promotes the Lysosomal Degradation of Hepatocyte Nuclear Factor 1α via Chaperone-Mediated Autophagy
... the HNF-1 ␣ protein contains the CMA-targeting motif in its POUs domain ...of HNF-1 ␣ (12). These findings suggest that HCV NS5A, HSC70, and HNF-1 ␣ form a protein ...and ...
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Hepatitis C Virus Infection Suppresses GLUT2 Gene Expression via Downregulation of Hepatocyte Nuclear Factor 1α
... Luciferase reporter assay. We constructed the human GLUT2 pro- moter-luciferase reporter plasmid by cloning a 1.6-kb genomic fragment that encompasses the human GLUT2 promoter region from ⫺ 1291 to ⫹ 308, yielding ...
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Regulation of Hepatocyte Nuclear Factor 1 Activity by Wild-Type and Mutant Hepatitis B Virus X Proteins
... (lanes 1 to 6). In lane 7, the lysates of cells transfected by pCMV-HNF-1 were analyzed directly by Western blotting without ...the HNF-1 protein ...Lane 1, HA- tagged X protein ...
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Developmental Stage-Specific Hepatocytes Induce Maturation of HepG2 Cells by Rebuilding the Regulatory Circuit
... , HNF-1 α , HNF-6 and the up- stream stimulatory factor (USF-1) play a key role in the maturation of embryonic hepatocytes; however, it is unclear whether the regulatory circuit mediates the ...
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Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors
... (HNF) 1 and Footprint B binding protein (FpB BP), decreased to 44 and 47% of pretreatment levels, respectively, while levels of the other known ntcp promoter transactivator, signal transducer and activator ...
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Assessing the association of the HNF1A G319S variant with C-reactive protein in Aboriginal Canadians: a population-based epidemiological study
... abnormal HNF-1 a produced by S319 carriers may have an impact on CRP production explaining the lower CRP level observed among non- diabetic individuals with the HNF1A G319S polymorph- ...of HNF-1a ...
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Binding of nuclear factors to functional domains of the duck hepatitis B virus enhancer.
... From these experiments, we conclude that the DHBV enhancer contains at least three binding sites for HepG2 nuclear factors: Fl, related to C/EBP; F2, related to HNF-1; and F3, related to[r] ...
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In Vivo Effects of Mutations in Woodchuck Hepatitis Virus Enhancer II
... the HNF-1 binding site was inactivated [IIB(2) and IIABC(2)] were seronegative for WHsAg for the entire testing period, and all but one were negative for anti-WHc as ...the HNF-4 site [mu- tant ...
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Alpha-fetoprotein-producing ovarian clear cell adenocarcinoma with fetal gut differentiation: a rare case report and literature review
... Conclusions: A total of three papers described the AFP-producing clear cell type EOC are available. The overall survival rate of these cases, including the current case is 50%. Although immunohistochemical examination is ...
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Genetic evidence that HNF 1α–dependent transcriptional control of HNF 4α is essential for human pancreatic β cell function
... major HNF-4 α isoforms in human exocrine and endocrine pancreas are transcribed from the P2 ...alternative HNF-4 α isoform is present in this particular islet cell type in humans, previous stud- ies using ...
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Expression of HNF-1β in cervical carcinomas: an immunohistochemical study of 155 cases
... factor 1 (HNF-1) transcription factor family includes HNF-1 (also known as HNF-1α, Tcf-1), and variant isoforms of the HNF-1 (vHNF-1) (also known as ...
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Original Article Diagnostic value of dual detection of hepatocyte nuclear factor 1 beta (HNF-1β) and napsin A for diagnosing ovarian clear cell carcinoma
... anti-human HNF-1β monoclonal antibody purchased from Santa Cruz Biotechnology, Inc (Dallas, ...known HNF-1β positive staining was used as a positive control for anti-HNF-1β, and tissue sections of ...
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In Vivo and In Vitro Analysis of Factor Binding Sites in Jaagsiekte Sheep Retrovirus Long Terminal Repeat Enhancer Sequences: Roles of HNF-3, NF-I, and C/EBP for Activity in Lung Epithelial Cells
... Table 1, and their relative positions are diagrammed in ...upstream HNF-3 site is important for JSRV LTR activity in MLE-15 cells (22), and this site showed evi- dence for factor binding in ...
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Cytoskeletal actin genes function downstream of HNF 3beta in ascidian notochord development
... Int J De\ BioI ~2 IOS5 109~ 1191lSJ Original lrlid,' Cytoskeletal actin genes function downstream of HNF 3~ in ascidian notochord development WilLIAM R, JEFFERy,,',3', NICHOLAS EWING3,,,, JANA MACHUlA[.] ...
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Otx2 and HNF3beta genetically interact in anterior patterning
... Midday of the day of the vaginal plug was considered as E0.5 in the timing of embryo collection. Embryos were dissected and staged according to morphological criteria (Kaufman, 1992). Embryos were photographed on a Leitz ...
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The MODY1 gene HNF 4α regulates selected genes involved in insulin secretion
... in HNF-4α–deficient β ...the HNF-4α mutants partially contrib- utes to the elevated basal insulin levels ...that HNF-4α also plays an important role in the developing pancreas prior to excision of ...
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The Effects of High Intensity Interval Training on HNF-4 α Gene Expression in Liver Tissue of Type 2 Diabetic Male Wistar Rats
... (6). HNF-4α is a transcription factor expressed in the liver, intestine, pancreas and kidneys, also plays an important role in regulating the transcription of the liver and pancreas ...of HNF-4a and Foxo1 ...
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