homologous recombination (HR)
The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy
... in homologous recombination (HR) mediated repair is considered one of the major mechanisms contributing to its tumor suppression activity, and the cause of hypersensitivity to poly(ADP-ribose) ...
14
Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers
... of homologous recombination deficiency and drug response A genomic scar can be defined as a genomic aberration with a known ...in HR may occur besides BRCA1/2 dysfunction have centered around the ...
11
How homologous recombination generates a mutable genome
... Homologous recombination (HR) is one of the fundamental mechanisms of DNA processing which, in various guises, is found in all phyla of ...1,2 HR is capable of playing several distinct roles ...
8
Adenosine deaminase (ADA) deficiency due to deletion of the ADA gene promoter and first exon by homologous recombination between two Alu elements
... by homologous recombination between two existing Alu repeats that flanked the ...26-bp recombination joint in the Alu sequence includes the 10-bp "B" sequence homologous to the RNA ...
6
BRCA2 and homologous recombination
... GFP recombination substrate to demonstrate that cells with defective BRCA2 protein are deficient in their ability to repair the I-SceI- induced DSB through homologous ...via homologous ...
5
Assembly and dynamics of the bacteriophage T4 homologous recombination machinery
... UvsX protein (44 kDa) is a member of the RecA/Rad51 recombinase family and shares 28% sequence identity and 51% sequence similarity with the catalytic core domain of E. coli RecA [12]. UvsX catalyzes DNA strand exchange ...
15
Association of BRCA1/2defects with genomic scores predictive of DNA damage repair deficiency among breast cancer subtypes
... (homologous recombination deficiency–loss of heterozygosity (HRD-LOH) score) [11], telomeric allelic imbalance (homologous recombination defi- ciency–telomeric allelic imbalance (HRD-TAI) ...
9
Multiple pathways for homologous recombination in Saccharomyces cerevisiae.
... MER 1987). The assay commonly used to measure mitotic recom- bination is the rate of prototroph formation between heteroalleles of an auxotrophic marker in diploids. rad5[r] ...
12
Dependence of frequency of homologous recombination on the homology length.
... dependence takes place is not altered in a case where the random-walk motion of the connecting structure is continuous along the homologous region. We found that such le[r] ...
13
Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancer
... a homologous recombination deficiency biomarker that indicates the inability of cancer cells to repair dsDNA breaks, result- ing in increased susceptibility to PARP inhibitors and platinum-based therapies ...
8
Lig4 and Rad54 Are Required for Repair of DNA Double-Strand Breaks Induced by P-Element Excision in Drosophila
... and HR is dependent on the RAD52 epistasis group pro- to prevent cytotoxicity and the formation of gross chro- teins, which were first identified in Saccharomyces cerevis- mosomal aberrations, faithful repair is ...
12
Pivotal Role of the Non-hr Origin of DNA Replication in the Genesis of Defective Interfering Baculoviruses
... (homologous recombination) of non-hr ori containing genomic DNA, followed by continued replication and consequent concatenation of this intervening ...another recombination event and rapidly ...
7
Update on Poly ADP ribose polymerase inhibition for ovarian cancer treatment
... the homologous recombination (HR) ...have HR deficiency, which is also present in a significant proportion of non-BRCA-mutated ovarian cancer (“BRCAness” ovarian ...
18
Advances in using PARP inhibitors to treat cancer
... Environmental exposures and cell replication result in DNA damage that is repaired by a variety of mechan- isms, including base excision repair (BER), mismatch repair (MMR), nucleotide excision repair (NER), single ...
5
Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene 1 mutant and wild type breast cancer cells
... undergo homologous recombination (HR) [15,16,18,19], therefore these cells cannot effectively repair HR-mediated DNA damage, including DNA double-strand breaks ...
14
Presence of alternative lengthening of telomeres associated circular extrachromosome telomere repeats in primary leukemia cells of chronic myeloid leukemia
... uses homologous recombination (HR) mediated replica- tion to specifically elongate telomeres, which often re- sults in different sizes of telomeres ...of HR by ALT positive cells can result in ...
7
Orientation Dependence in Homologous Recombination
... In the recBC sbcA strain (RecE pathway), on the other hand, we have reported apparent gene conversion often accompanied by apparent crossing-over of the flanking sequences [r] ...
10
Unique molecular mechanisms for maintenance and alteration of genetic information in the budding yeast Saccharomyces cerevisiae
... that homologous integration efficiency was markedly increased by the inactivation of NHEJ- related ...of homologous inte- gration were markedly increased, reaching almost 100% de- pending on the length of ...
15
Mechanisms of interstrand DNA crosslink repair and human disorders
... homologous recombination (HR), and factors responsible for Fanconi anemia (FA) are identified to be involved in ICL repair. Since the presence of ICL lesions causes severe defects in transcription ...
8
DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens
... (MMR), homologous recombination repair (HR) and non-homologous end joining repair ...signaling, HR and sub-pathways of NER and ...
20