Host and viral protein interaction
Visualization of Host-Polerovirus Interaction Topologies Using Protein Interaction Reporter Technology
... PIR-defined interaction between the substrate binding do- main of the ER chaperone BiP and the arginine-rich region of PLRV CP monomer uncovered a highly conserved CP peptide domain rich in hydrophobic, neutral ...
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Interaction of Foot-and-Mouth Disease Virus Nonstructural Protein 3A with Host Protein DCTN3 Is Important for Viral Virulence in Cattle
... these host proteins, identified as bovine DCTN3 (NCBI reference sequence ...3A-DCTN3 interaction occurs during FMDV infection of host cells, the localization of 3A and DCTN3 during infection was ...
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Training host pathogen protein–protein interaction predictors
... a host protein ℎ and viral protein 𝑣 to the dissimilarity score of 𝑣 with its most similar viral protein that interacts with the host protein ...a host ...
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Analysis of the interaction between host factor Sam68 and viral elements during foot and mouth disease virus infections
... Sam68 interaction with the FMDV IRES could impact other functions that this protein exerts that are needed for efficient virus ...pol interaction is the charge complementarities between the binding ...
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Viral cystatin evolution and three-dimensional structure modelling: A case of directional selection acting on a viral protein involved in a host-parasitoid interaction
... on viral cystat- ins to modify the inhibitor's sites of interaction with host target proteases, which could translate into an increased or reduced affinity towards these ...of viral cystatins ...
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COVID-19 comorbidity and metabolic syndrome: is there a Molecular basis?
... coded protein interacting host proteins are associated with CVD, diabetes, or NAFLD relevant biological processes, pathways and ...diseases/traits. Interaction of the viral proteins alters the ...
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Extensive Positive Selection Drives the Evolution of Nonstructural Proteins in Lineage C Betacoronaviruses
... all viral genes. Mutation accrual continued for a long time after the host shift, suggesting that multiple mutations progres- sively optimize viral fitness in the new host (70); many of these ...
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Elucidation of the ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function
... the interaction partners of VP24, we used quantitative proteomics coupled to an immunoprecipitation strategy based on expressing VP24 as an EGFP-fusion in human 293-T cells and utilizing a GFP-trap to selectively ...
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ACBD3 Is an Essential Pan enterovirus Host Factor That Mediates the Interaction between Viral 3A Protein and Cellular Protein PI4KB
... ABSTRACT The enterovirus genus of the picornavirus family includes a large num- ber of important human pathogens such as poliovirus, coxsackievirus, enterovirus A71, and rhinoviruses. Like all other positive-strand RNA ...
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Generation and Comprehensive Analysis of an Influenza Virus Polymerase Cellular Interaction Network
... the viral polymerase ...cellular protein could contribute to viral replication at specific steps that cannot be detected with the minigenome system, like virus assembly or trafficking (2, ...thus ...
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Disruption of Stress Granule Formation by the Multifunctional Cricket Paralysis Virus 1A Protein
... and host transcription, CrPV-1A, to our surprise, stimulates 5=-end-dependent translation ...of host trans- lation in CrPV-infected cells, we discovered that CrPV-1A stimulated 5=-end-dependent translation ...
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Chikungunya Virus Induces IPS-1-Dependent Innate Immune Activation and Protein Kinase R-Independent Translational Shutoff
... cellular protein translation was still seen following siRNA-mediated knock- down of PKR expression ... protein following CHIKV infection ...ISG) protein synthesis, which was restored during PKR ...
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Issues in performance evaluation for host–pathogen protein interaction prediction
... Fig. 2. Evaluation methodologies for host-pathogen protein interactions (HPIs) predictors. In K-fold cross validation, we have separated our data into as many folds as the number of pathogen proteins. Then, ...
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Vesicular stomatitis virus matrix protein inhibits host cell-directed transcription of target genes in vivo.
... To determine whether the viral matrix M protein was involved in this inhibition of host cell gene expression, an M protein expression vector was cotransfected with a target gene vector, [r] ...
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Interaction of the HeLa cell protein EBP1 with viral and cellular enhancers
... only protein involved in repression by the oi2 ...regulatory protein, bound to the centre of the operator, which is also required for ...yeast protein, GRM (general regulator of mating type), which ...
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Interaction of influenza M protein with viral lipid and phosphatidylcholine vesicles.
... The membrane or matrix M protein of the virus is localized directly beneath the lipid bilayer and appears as a tightly adherent sac sur- The work reported here was carried out to determi[r] ...
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Mapping the Interactions between the NS4B and NS3 Proteins of Dengue Virus
... G124 and D154A and the wild-type viruses. In agreement with the IFA results, the plaque assay indicates that no infectious virus was produced for the mutant Q134A (Fig. 7B). Mutant G140A pro- duced a small amount of ...
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Ebola Wars.pdf
... “Th e next step is viral synthesis. So, it looks like once the virus enters my cells it hijacks the cell machinery including many of my cells’ enzymes and ribosomes normally used to make my own proteins. Th e ...
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Gene product of region E4 of adenovirus type 5 modulates accumulation of certain viral polypeptides.
... The defects in viral DNA replication, late protein synthesis, and shutoff of host cell protein synthesis associated with the phenotype of the H2dl8O8 mutant were not observed in HeLa cel[r] ...
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Random mutagenesis of NS1 protein of influenza a H1N1 and docking of RNA aptamers to wild type and mutant NS1 proteins
... NS1A protein as well as mutants can be chosen as the molecular diagnostic tool or antiviral agent against H1N1 ...specific viral proteins can be used as an alternative to the stable vaccines and antibodies ...
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