HPLC-MS
Validation of an HPLC-MS method for the determinatin of vardenafil in rat urine
... A simple and reliable method for the determination of vardenafil in the urine of white rats is described using HPLC-MS on the Zorbax SB-C18 reversed-phase column. The proposed conditions of the ...
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Development and validation of a HPLC/MS/MS method for the quantification of Cocaine and its principal metabolite
... The experimental results demonstrate that the proposed HPLC-MS/MS method is simple and less time consuming, accurate, precise and selective. It offers preferential advantages over most of the ...
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HPLC MS/MS method for analysis of isoproturon in difficult matrix: poppy seeds
... task, HPLC-MS/MS method was ...For HPLC separation of isoproturon SPE fraction Lichrospher C18 column (25 cm × 4 mm, 5 µm) was ...and MS/MS mode was ...
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A pilot data analysis of a metabolomic HPLC-MS/MS study of patients with COPD
... Our study shows that the HPLC-MS/MS method is able to show minute changes in the metabolism of patients shown on a molecular level. The significance of many of these differences is not yet ...
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Simultaneous measurement of multiple organic tracers in fine aerosols from biomass burning and fungal spores by HPLC MS/MS
... and MS/MS have been optimized to ensure good identi fi cation and pronounced intensity for each ...and HPLC-MS/MS has been successfully applied to environmental aerosol samples of di ff ...
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Estimation of Mycotoxin Multiple Contamination in Mexican Hybrid Seed Maize by HPLC MS/MS
... naria alternate, Alternariol (AL) and Methyl ethyl alternariol (AM) [13]. Various methods have been used to isolate and quantify the levels of mycotoxins, such as liquid chromatography with fluorescense detector ...
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Characterization of Some Flavonoids in Phoenix dactylifera L Using HPLC MS MS
... hazardous. HPLC–MS plays a prominent role as an analytical tool for detecting and identifying pharmacologically active metabolites and/or reactive metabolites (V and all 2009), (Xing, J and all ...methods, ...
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Determination of Fragmentation Schemes and Metabolites of Fluorinated Histone Deacetylase Inhibitors for Use as Positron Emission Tomography Imaging Agents Using HPLC MS/MS
... To determine the synthesis qualities, and bio-reaction rates of the INER-1577s and identify their derivatives, reverse phase HPLC-MS/MS was initially set up for the determination of INER-157 7#3. ...
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Hplc ms/ms method development and validation for determing stability of alectinib in human plasma samples
... (Fig.1) and its molecular weight is 482.61656. Alectinib was used for the treatment of bitor (Hiroaki et al., Prideaux, 2012; Sugiura, The literature survey reveals that, a variety of methods were reported on the ...
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Chemical fingerprinting and quantitative analysis of a Panax notoginseng preparation using HPLC-UV and HPLC-MS
... Xuesaitong (XST) injection, consisting of total saponins from Panax notoginseng (Sanqi), was widely used for the treatment of cardiovascular and cerebrovascular diseases in China. As total saponins (including ...
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<p>A New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma</p>
... Agilent HPLC- MS/MS system “ (6410 QqQ) ” , and HPLC Agilent 1200 series system consisting of a binary pump (G1311A) degas- ser (G1322A), autosampler (G1367B) and thermostatted column ...
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Rapid DA determination of ASP in shellfishes by SPE HPLC MS/MS
... A method of the high performance liquid chromatography-tandem mass spectrometry was established to detect acids shellfish poisoning (domoic acid) residues in aquatic products. Toxin was extracted with 50% methanol by ...
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Identification and quantification of anthocyanins in muscadine grapes by HPLC and HPLC MS
... Total anthocyanin content and individual anthocyanin profile of ten cultivars of muscadine grapes were assessed. Total anthocyanin content was determined by a pH differential method. Individual anthocyanins were analyzed ...
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DEVELOPMENT AND VALIDATION OF A HPLC/MS/MS METHOD FOR THE DETERMINATION OF ALBUTEROL IN HUMAN PLASMA
... Prior to analysis, all frozen subjects samples, calibration standards and quality control samples were thawed and allowed to equilibrate at room temperature. To an aliquot of 500 µL of spiked plasma sample, 50 µL ...
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Exorphin Peptides In Urine With Hplc-Ms/Ms Detection
... We wish to report the fast peptide degradation when urine is kept at room temperature. The addition of boric acid has been used by some to prevent peptide degradation, while we routinely used fast freezing of the ...
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DEVELOPMENT AND VALIDATION OF A LIQUID CHROMATOGRAPHY ELECTRO SPRAY IONIZATION MASS SPECTROMETRY METHOD FOR THE QUANTITATION OF ERGOCALCIFEROL IN HUMAN PLASMA
... CONCLUSION: For the very first time a highly sensitive and selective method for the quantitative determination of ergocalciferol in human plasma was developed using HPLC-MS/MS with turbo-ion spray in ...
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The oral bioavailability, excretion and cytochrome P450 inhibition properties of epiberberine: an in vivo and in vitro evaluation
... α -Hydroxymetoprololin and phenacetin (IS) in HLM and RLM were analyzed via the previously described HPLC-MS/ MS system and the same type column. The mobile phase consisted of a mixture of ...
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High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation
... a HPLC-MS/MS method was developed analyzing LTB4, LXA4, RvE1 and RvD1 and the four hydroxy fatty acids 17-hydro- xydocosahexaenoic acid (17-HDHA), 18-hydroxyeico- sapentaenoic acid (18-HEPE), ...
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Analytical methods for the determination of paracetamol, pseudoephedrine and brompheniramine in Comtrex tablets
... PAR; N-(4-hydroxyphenyl) acetamide reduces pain and fever used in the treatment of arthritis, tooth ache and headaches [1]. It is a major constituent in many cold and flu medications. PAR can also be administered for ...
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In vitro and in vivo quantification of chloroprocaine release from an implantable device in a piglet postoperative pain model
... Figure 3 in vitro detections through hPlc-Ms/Ms of the concentrations of chloroprocaine and acBa metabolite released from drug-loaded hydrogel after being in contact with plasma at [r] ...
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