HS, heparan sulfate
Heparan Sulfate Facilitates Rift Valley Fever Virus Entry into the Cell
... charged HS binding motif (6, 8, 20, ...a HS-binding motif during these procedures, the M segment-encoded polypeptide se- quence was aligned with those of four RVFV isolates that had been directly sequenced ...
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Antiproliferative heparan sulfate inhibiting hyaluronan and transforming growth factor-β expression in human lung fibroblast cells
... between HS and the reorganization of the cytoskeletal proteins, though the structural differences between the two HS forms seem to be of less importance in this ...both HS forms and has been ...
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Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis
... chondroitin sulfate was degraded with 0.02 U of chondroitinase ABC (18). HS was purified by phe- nol extraction and ethanol precipitation (18), then mass was determined by forming complexes with Alcian blue ...
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Drosophila Pipe protein activity in the ovary and the embryonic salivary gland does not require heparan sulfate glycosaminoglycans
... standard conditions and procedures. Larval cuticles were prepared according to Van der Meer (Van der Meer, 1977). The wild-type stock used was Oregon R. Mutant alleles have been described as follows: pipe 1 and pipe 2 ...
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Wingless, Hedgehog and Heparan Sulfate Proteoglycans
... Second, as pointed out by Perrimon and Häcker (Perrimon and Häcker, 2004), rescue of dally and dlp RNAi by transgene expression of Wg could be a consequence of overexpression. This suggestion is based on the observation ...
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Heparan sulfate is an important mediator of Ebola virus infection in polarized epithelial cells
... of HS distribution and glycosylation during Caco-2 cell polarization have been reported ...a heparan sulfate proteoglycan, was found to be mostly expressed at the basolateral surface, an unex- pected ...
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Jones_unc_0153D_12064.pdf
... Heparan sulfate (HS) has been implicated in various biological activities including ...of HS polysaccharides, is a commonly used anticoagulant ...anticoagulant heparan sulfate ...
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Cell-autonomous heparanase modulates self-renewal and migration in bone marrow-derived mesenchymal stem cells
... Together with previous findings and our work, three models are postulated to depict the possible roles of heparan sulfate in mouse BM-MSCs (Figure 7). Firstly, HPSE might quench putative external signals ...
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Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF β2 signaling
... that heparan sulfate (HS) deficiency in mouse neural crest cells causes anterior chamber dysgenesis, including corneal endothelium defects, corneal stroma hypoplasia, and iridocorneal angle ...for ...
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Molecular diversity of heparan sulfate
... In spite of the detailed information available about primary sequence of the isozymes and the evolving information about their substrate preferences, the for- mation of binding sites for antithrombin and glyco- protein ...
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Chemoenzymatic synthesis of heparan sulfate
... The FGFs are a family of growth factors involved in angiogenesis, wound healing, and embryonic development (4, 19). A total of 22 different isoforms of FGF have been reported (41). FGFs are key players in proliferation ...
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The enzymatic degradation of heparan sulfate
... The human Hep1 cDNA was first reported independently by three groups, all of whom purified Hep1 from human tissues and used derived sequences to screen EST databases [35,37,39]. Identification of the Hep1 cDNA was ...
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Heparan sulfate hexasaccharide selectively inhibits cancer stem cells self-renewal by activating p38 MAP kinase
... We applied this dual screening strategy to a library of sulfated GAGs, i.e., HS and chondroitin sulfate (CS), of varying chain lengths and constitution. The rationale for choosing this library was that ...
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Heparan Sulfate Dependent Enhancement of Henipavirus Infection
... of HS because of their deficiency in GAG bio- synthesis enzymes (15) were also highly deficient in their ability to mediate trans-infection of NiV ...the HS analog heparin by using surface plasmon resonance ...
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Single-Molecule Fluorescence Detection of a Synthetic Heparan Sulfate Disaccharide
... structurally-specific heparan sul- fate (HS) ...charide HS, along with the related GAG heparin, is known to bind a wide variety of proteins including chemokines and growth ...of HS, structural ...
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Early Events in Kaposi's Sarcoma-Associated Herpesvirus Infection of Target Cells
... with heparan sulfate (HS) followed by temporal interactions with ␣ V  5, ␣ 3  1, and ␣ V  3 integrins and xCT (CD98) molecules which overlap with the induction of host cell preexisting signal ...
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Effect of heparan sulfate and gold nanoparticles on muscle development during embryogenesis
... The present results have shown that cell and/or tissue requirements for functional compounds like sulfur-containing molecules may be a critical point for proper maturation and functioning of muscle. Moreover, nano-Au did ...
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Vaginal Heparan Sulfate Linked to Neutrophil Dysfunction in the Acute Inflammatory Response Associated with Experimental Vulvovaginal Candidiasis
... findings, HS may represent a novel marker capable of exploitation for therapeutic ...include HS neutralization by intravaginal administration of soluble recombinant Mac-1 or hepara- nase to CVVC-S mice ...
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Biochemical characterization of human heparan sulfate 6-O-endosulfatase
... Loss of HSul-1 expression increases both autocrine and paracrine proliferation signaling by amphiregulin and heparin binding epethelilial growth factor (HB-EGF), HB- growth factors of the EGF superfamily, and ...
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Sulfation of chondroitin sulfate proteoglycans is necessary for proper Indian hedgehog signaling in the developing growth plate
... 2005). Heparan sulfate proteoglycans (HSPGs) and chondroitin sulfate proteoglycans (CSPGs) are two major classes of proteoglycans, differentiated by their GAG compositions and sulfation patterns ...
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