HSP27 expression
Therapeutic potential of Hsp27 in neurological diseases
... with Hsp27 as the target protein. Hsp27 binds to Aβ inhi- biting its aggregation into mature fibrils ...and Hsp27 from humans and their capability in lowering toxicity of Aβ ...that Hsp27 ...
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Altered expression of glomerular heat shock protein 27 in experimental nephrotic syndrome
... involve hsp27 in any of three manners: (a) The stimulus might induce hsp27 expression and phosphorylation within GECs, resulting in dis- ruption of the delicate balance between actin polymerization ...
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Downregulated expression of HSP27 in human low-grade glioma tissues discovered by a quantitative proteomic analysis
... differentital expression profiling of HSPs between human glioma tissues (HGTs) and autologous para-cancerous brain tissues ...the expression variations of HSP27 by heat shock in a glioma-derived cell ...
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Original Article Mechanism of bladder dysfunction in the diabetic rat
... of HSP27 and phosphorylated CaD can lead to the dissocia- tion of CaD and TM, which regulates the con- traction of colon smooth ...of HSP27 in the contraction of bladder smooth muscles has also not been ...
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Original Article Effect of glucose concentration on the expression of HSP27, CaD and TM proteins in rat detrusor smooth muscle cells
... of HSP27 expression and increased phosphorylation level in myometrium during late pregnancy and parturition are close- ly associated with enhanced uterine contractil- ...the expression and activation ...
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Hsp27 participates in the maintenance of breast cancer stem cells through regulation of epithelial mesenchymal transition and nuclear factor κB
... Recently, Hsp27 has been proven to contribute to the drug resistance property of lung cancer stem cells ...The expression of Hsp27 was increased in lung CSCs trea- ted with ...inhibit Hsp27 ...
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The significance of phosphorylated heat shock protein 27 on the prognosis of pancreatic cancer
... their HSP27 expression level score or positive p-HSP27 ratio were associated with survival in a univariate analysis using a log-rank ...the HSP27 expression level score and a positive ...
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Anti-Vpr Activities of Heat Shock Protein 27
... human HSP27 suggests that HSP27 might be a functional paralogue of Hsp16 because they both share the same motif of the HSP20/α crystalline family (27) and anti-HSP27 antibodies weakly cross-reacted ...
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Hsp27 Responds to and Facilitates Enterovirus A71 Replication by Enhancing Viral Internal Ribosome Entry Site-Mediated Translation
... that Hsp27 is phosphorylated upon HSV-1 infection and that depletion of Hsp27 reduces herpes simplex virus 1 production ...of Hsp27 (40). In the case of HBV infection, Hsp27 acts as an ...
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The Role of Heat Shock Proteins in Mammary Neoplasms: A Brief Review
... high expression of HSP27 gene has been found to be associated with in- creased anchorage-independent growth, invasion, metas- tasis and resistance to chemotherapeutic drugs ...between HSP27 ...
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Primary tumor- and metastasis-derived colon cancer cells differently modulate connexin expression and function in human capillary endothelial cells
... protein HSP27 was more expressed in, and secreted by, primary tumor- derived SW480 cancer cells when compared to their metastasis-derived counterpart SW620 cells ...the expression of HSP27 in the two ...
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Clinicopathological significance of HSP27 in gastric cancer: a meta-analysis
... positive HSP27 expression and clinicopathological features (lymph node metastasis [yes vs no], serosal invasion [yes vs no], gender [male vs female], tumor size [#5 cm vs ...the expression of ...
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The clinicopathological and prognostic value of HSP27 in hepatocellular carcinoma: a systematic review and meta-analysis
... (HSP27 expression, gender, hepatitis B virus surface antigen [HbsAg], α -fetoprotein [AFP], tumor size, metastasis, vascular invasion, tumor differentiation, and TNM stage) and hazard ratios (HRs) with 95% ...
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PubMedCentral-PMC4810618.pdf
... gene expression in HCMV-infected monocytes suggests that HCMV may be regulating cellular signal- ing pathways during viral entry to rapidly induce Mcl-1 and HSP27 ...increased HSP27 expression ...
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Androgen receptor and heat shock protein 27 co-regulate the malignant potential of molecular apocrine breast cancer
... chaperones, HSP27 forms a chaperon- ing oligomer which can regulate multiple cellular sur- vival and signaling pathways ...whether HSP27 combines with the AR during its translocation from the cytoplasm to ...
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Research on the efficacy of Celastrus Orbiculatus in suppressing TGF β1 induced epithelial mesenchymal transition by inhibiting HSP27 and TNF α induced NF κB/Snail signaling pathway in human gastric adenocarcinoma
... the expression of HSP27 in vivo, which provides a scientific proof to treat patients with gastric cancer by the rationale in the ...that HSP27 possesses different functions, the roles of HSP27 ...
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Immunohistochemical expression of heat shock proteins in the mouse periodontal tissues due to orthodontic mechanical stress
... Traditionally, major proteins expressed in various tissues and organs due to mechanical load and stimula- tion of cytotoxic stress that is transiently expressed are known as heat shock proteins (HSPs) [9]. HSPs are not ...
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Overexpression of mutant HSP27 causes axonal neuropathy in mice
... and HSP27-S135F mice (Table 1 and Fig. 3). These data suggest that HSP27-S135F transgenic mice have abnormal motor function and the phenotype is consist- ent with CMT2 or dHMN, rather than CMT1, which is ...
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The expression of heat shock protein hsp27 and a complexed 22-kilodalton protein is inversely correlated with oncogenicity of adenovirus-transformed cells.
... The correlation of oncogenicity with the absence of the 22- and 27-kDa proteins is even better than the correlation of oncogenicity with the lack of expression of the class I MHC antigen[r] ...
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New HSP27 inhibitors efficiently suppress drug resistance development in cancer cells
... between HSP27 and a viral thymidine kinase (VTK). A 3D structural model of HSP27 and a crystalized structure of VTK showed a similar binding site with five identical residues in exactly the same geometric ...
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