hub genes
Identification of hub genes with diagnostic values in pancreatic cancer by bioinformatics analyses and supervised learning methods
... few genes at once, which limits large-scale investigation of hub genes and pathways in the systematic biology ...critical genes but also can detect corresponding path- ways and/or interactive ...
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Integrated transcriptomic analysis reveals hub genes involved in diagnosis and prognosis of pancreatic cancer
... In the recent years, gene expression data from the public database, such as the Cancer Genome Atlas Can- cer Genome (TCGA), Gene Expression Omnibus (GEO), offer available information with respect to the molecular ...
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<p>Identification of Critical Pathways and Hub Genes in LanCL1-Overexpressed Prostate Cancer Cells</p>
... central genes with the highest degree of ...top hub gene, which is mainly secreted by ...15 hub genes, we also identified 4 hub genes that strongly associated with clinical out- ...
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Ten hub genes associated with progression and prognosis of pancreatic carcinoma identified by co-expression analysis
... A workflow of this study is shown in Figure 1. We downloaded expressing profiles of mRNA of human pancreatic cancer from Gene Expression Omnibus (GEO) database (http://www.ncbi.nlm.nih. gov/geo/). Dataset GSE62452 ...
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Identification of five hub genes as monitoring biomarkers for breast cancer metastasis in silico
... network hub genes (MM > ...five hub genes ( TPX2, KIF2C, CDCA8, BUB1B , and CCNA2 ) were identified as key genes associated with breast cancer ...these genes were validated ...
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Transcriptome sequencing identified hub genes for hepatocellular carcinoma by weighted-gene co-expression analysis
... We validated three of four selected hub genes in 15 hub genes (Figure 5E). Rucinski et al. [44] ascertained the role of spexin (SPX) in the regulation of cell proliferation (e.g., in adrenal ...
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Original Article Scree ning of hepatocellular carcinoma hub genes and construction of a control network
... These genes are mainly involved in the cellular composition of extracellular bodies, organelle membranes, and membrane attack ...of genes was conducted in the most closely connected and important nodes of ...
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Identification of four hub genes as promising biomarkers to evaluate the prognosis of ovarian cancer in silico
... 4 genes (COL6A3, CRISPLD2, FBN1 and SER- PINF1) in OvCa patients based on another microarray and the findings confirmed the reliable values for prog- nostic ...four hub genes and the interacted ...
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Bladder cancer stage-associated hub genes revealed by WGCNA co-expression network analysis
... The R package of “WGCNA” was used to classify 13,222 genes with similar expression levels into different modules. In our research, β = 8 was set to guarantee high scale inde- pendence (near 0.9) and low mean ...
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Identification of hub genes and therapeutic drugs in esophageal squamous cell carcinoma based on integrated bioinformatics strategy
... Interacting Genes (STRING) database (https ://strin ...10 hub genes with high degree of connectivity were selected and mapped into PPI based on STRING following confidence score ≥ ...
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Identification of hub genes and outcome in colon cancer based on bioinformatics analysis
... the hub genes levels between cancer patients and healthy controls were detected using GEPIA ...the hub genes was also performed using GEPIA, and Figure S2 shows that the mRNA levels of CXCL5 ...
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Identification of hub genes with prognostic values in gastric cancer by bioinformatics analysis
... expressed genes (DEGs) were obtained using ...of hub genes on overall survival (OS) was performed by the Kaplan-Meier plotter online ...of hub genes were predicted by miRecords and ...
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<p>Identification of Hub Genes in Type 2 Diabetes Mellitus Using Bioinformatics Analysis</p>
... Interleukin-6 (IL6) is a cytokine that functions in in fl am- mation and the maturation of B cells. 25 Also, it plays an essential role in the fi nal differentiation of B-cells into immu- noglobulin-secreting cells which ...
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Identification of Hub genes and key pathways associated with atopic
... Taken together, the top 200 protein genes acquired from Open Targets Platform and later integrated analysis. 284[r] ...
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RETRACTED ARTICLE: Investigation of the hub genes and related mechanism in ovarian cancer via bioinformatics analysis
... The nodes and edges of the PPI network were so com- plicate that we need to conduct the enrichment analysis using the ClusterONE Cytoscape plug-in [23]. Minimum size >5 and minimum density < 0.05 were the ...
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Integrated characterization and validation of the prognostic significance of microRNA-200s in colorectal cancer
... get genes of miR-200s were predicted and applied for functional enrichment ...target genes of miR-200s were mainly enriched into some vital ontology subjects such as regulation ability, key cell structures ...
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Gene regulatory network reveals oxidative stress as the underlying molecular mechanism of type 2 diabetes and hypertension
... of genes and proteins along with their regulatory networks ...aberrant genes, their connections and their functions- to elucidate the underlying molecular mechan- ...mined genes differentially ...
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Original Article Prediction of gene signatures for diagnosing concurrent of acute myeloid leukemia and chronic lymphoblastic leukemia
... common genes were mapped on the general ...interacting genes (STRING) database is a public resource of known and predicted gene direct and indirect interactions, which is used ...work, genes with ...
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Identification of prognostic factors for intrahepatic cholangiocarcinoma using long non-coding RNAs-associated ceRNA network
... five hub genes might regulate the development of ICC by targeting the “TGF-β signaling pathway”, “the hedgehog signaling pathway”, “retinol metabolism”, or “type II diabetes ...
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Identification of key pathways and genes with aberrant methylation in prostate cancer using bioinformatics analysis
... of genes involved in progression of PCa using computational ...methylated genes (DMGs), which are reported to be epigenetically dysregulated, and identified 26 genes that significantly contribute to ...
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