Human Fc
Allelic polymorphisms of human Fc gamma receptor IIA and Fc gamma receptor IIIB Independent mechanisms for differences in human phagocyte function
... of human Fc gamma receptors have been defined: the low-responder (LR)-high-responder (HR) polymorphism of huFc gamma RIIA expressed on both PMN and monocytes and the NA1-NA2 polymorphism of the neutrophil ...
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Human Fc gamma RII, in the absence of other Fc gamma receptors, mediates a phagocytic signal
... of Fc gamma RI and Fc gamma RII in isolation and in combination, in transfected COS-1 ...cells. Fc gamma RIIA-transfected COS cells also mediated both the binding and phagocytosis of IgG-sensitized ...
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Genetic diversity in human Fc receptor II for immunoglobulin G: Fc gamma receptor IIA ligand-binding polymorphism.
... Studies of platelet activation by murine antiplatelet monoclonal antibodies via the platelet Fc-yRIIA receptor reveal three distinct patterns of behavior most likely corre-.. sponding to[r] ...
5
Function and heterogeneity of human Fc receptors for immunoglobulin G
... huFcRI HuFc7RI, found predominantly on monocytes and macrophages, binds monomeric human IgG with high avidity Ka = 1-3 X 108 M-' and with a subclass specificity of IgGl > IgG3 > IgG4 > I[r] ...
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Utilization of Immunoglobulin G Fc Receptors by Human Immunodeficiency Virus Type 1: a Specific Role for Antibodies against the Membrane-Proximal External Region of gp41
... expressing Fc ␥ Rs exhibit differential binding of IgG ...of Fc ␥ Rs ex- pressed on TZM-bl cells was evaluated with human myeloma ...IgG4 human myeloma proteins were incubated with a ...
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Molecular Mechanism for LAMP1 Recognition by Lassa Virus
... A-conjugated beads is compared to those of GP1-Fc variants harboring a His-to-Tyr mutation in each of the three conserved histidines. LAMP1 was detected using anti-LAMP1 antibody. All three mutations significantly ...
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Characterization of Antibody Bipolar Bridging Mediated by the Human Cytomegalovirus Fc Receptor gp68
... and non-ABB conditions (8). We chose gD as the model antigen because it is a cell surface glycoprotein found on virions and in- fected cells (18), and fusion of its cytoplasmic tail to a fluorescent protein did not ...
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The Human Cytomegalovirus Fc Receptor gp68 Binds the Fc CH2-CH3 Interface of Immunoglobulin G
... their Fc binding ...with human Fc ␥ and protein A-Sepharose or with goat anti-FLAG antibody coupled to agarose or with mouse anti-V5 antibodies and protein ...of Fc ␥ due to cross-reactivity ...
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Neutralization of Hepatitis A Virus (HAV) by an Immunoadhesin Containing the Cysteine-Rich Region of HAV Cellular Receptor-1
... and Fc portion of human ...and Fc region with D1-Fc and was expressed in CHO cells as described ...anti-human Fc antibodies to test the cell culture medium of single-cell clones ...
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Purified and Recombinant Hemopexin: Protease Activity and Effect on Neutrophil Chemotaxis
... Recombinant Fc-hHx has the same heme-binding activity as purified Hx. Recombinant Fc-hHx prepared as described in Materials and Methods was applied to SDS-PAGE with Coomassie Fluor Orange (Life ...
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Novel Fc gamma receptor I family gene products in human mononuclear cells
... the human Fc gamma RII and Fc gamma RIII families, which exhibit considerable diversity at both the nucleic acid and protein levels, the human Fc gamma RI family has only a single ...
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Modulation of T cell responses to alloantigens by TR6/DcR3
... We noticed that inhibition of proliferation in the mouse in vivo MLR (the graft-versus-host response) by TR6 was not complete even with high concentrations of TR6. The same was also true for the effect of TR6 on IL-2 ...
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Production in yeast of pseudotype virus-like particles harboring functionally active antibody fragments neutralizing the cytolytic activity of vaginolysin
... diameter. As the crystal structures of the virions of SV- 40 [31] and murine polyomavirus [32] have been resolved, it is known that the capsid of polyomaviruses mainly consists of 72 pentamers formed by 360 copies of the ...
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A Mediated BOD Microsensor Based on Poly(Neutral Red) and Bacteria Modified Interdigited Ultramicroelectrode Array
... immobilized FC mediator in an ion-exchangeable polysiloxane for BOD ...immobilized FC- mediated BOD sensor through electropolymerization of ...immobilized FC mediators would have poor long-term ...
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Functional and Selective Targeting of Adenovirus to High-Affinity Fcγ Receptor I-Positive Cells by Using a Bispecific Hybrid Adapter
... the Fc␥ receptors, the cells listed in Table 1 were incubated with AdCMV-eGFP at an MOI of 10, either alone or premixed with ...the Fc␥ receptor but not to Ad, no effect on eGFP expression was observed ...
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A role for surface lymphotoxin in experimental autoimmune encephalomyelitis independent of LIGHT
... the human MS-diseased brain and chronically inflamed sites, there may be ample ligand present to trigger chemokine secre- tion and subsequent leukocyte influx ...
14
AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges
... the human IgG1 Fc domain (e), one bearing rhesus CD4 domains 1 and 2 with the I39N mutation, again fused to the human IgG1 Fc domain (f), or the antibody NIH45-46 fused to the rhesus IgG2 ...
31
Human IgG Fc domain engineering enhances antitoxin neutralizing antibody activity
... with Fc effector activity is crucial for optimal in vivo activity for protection against microbial pathogens and their toxins ...the Fc domain for the specific receptor and the expression pattern of those ...
6
Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions
... In a murine model of immune thrombocytopenic purpura, Sam- uelsson et al. showed that IVIG requires the presence of CD32b to mediate protective antiinflammatory effects and that IVIG increas- es CD32b expression on ...
11
Volatility and return forecasting:time series and options based methods
... adaptive Lasso AR-FC adaptive Lasso HAR-FC adaptive Lasso slopeHAR-FC adaptive Lasso freeHAR-FC ordered Lasso AR-FC horizon=5 HAR slopeHAR freeHAR.. adaptive Lasso AR adaptive Lasso HAR [r] ...
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